Results 301 to 310 of about 2,316,796 (350)
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Annals of the New York Academy of Sciences, 1990
In rabbits the contractile response of the urinary bladder is only partially due to cholinergic innervation since atropine does not completely block neuronally mediated contractions. In the human bladder this atropine resistance is controversial with some reporting atropine resistance in vitro while others have stated that the atropine resistance is ...
Michael R. Ruggieri +2 more
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In rabbits the contractile response of the urinary bladder is only partially due to cholinergic innervation since atropine does not completely block neuronally mediated contractions. In the human bladder this atropine resistance is controversial with some reporting atropine resistance in vitro while others have stated that the atropine resistance is ...
Michael R. Ruggieri +2 more
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ACS Applied Materials and Interfaces, 2018
Adenosine triphosphate (ATP) is an important transmitter that mediates various biological effects via purinergic receptors (P2 receptors) in cancer. We investigated the antitumor activity of ATP-decorated and doxorubicin (DOX)-loaded mesoporous silica ...
Prateek Srivastava +7 more
semanticscholar +1 more source
Adenosine triphosphate (ATP) is an important transmitter that mediates various biological effects via purinergic receptors (P2 receptors) in cancer. We investigated the antitumor activity of ATP-decorated and doxorubicin (DOX)-loaded mesoporous silica ...
Prateek Srivastava +7 more
semanticscholar +1 more source
Signaling at Purinergic P2X Receptors
Annual Review of Physiology, 2009P2X receptors are membrane cation channels gated by extracellular ATP. Seven P2X receptor subunits (P2X1-7) are widely distributed in excitable and nonexcitable cells of vertebrates. They play key roles in inter alia afferent signaling (including pain), regulation of renal blood flow, vascular endothelium, and inflammatory responses.
Surprenant, Annmarie, Alan North, R.
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Purinergic receptors, prostacyclin and atherosclerosis
Pharmacological Research, 1992Over the last decade, evidence has been provided that endothelial cells have a metabolic function in order to maintain blood vessel homeostasis. The endothelium releases relaxing and contracting factors in response to endogenous or exogenous substances such as acetylcholine, calcimycine, adenosine 5'triphosphate (ATP), bradykinin, arachidonic acid and ...
RAGAZZI, EUGENIO, CHINELLATO A.
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Current Pharmaceutical Design, 2009
There is a brief summary of the early background literature about purinergic signalling and its involvement in pain, of ATP storage, release and ectoenzymatic breakdown and of the current classification of receptor subtypes for purines and pyrimidines. The review then focuses on purinergic mechanosensory transduction involved in visceral, cutaneous and
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There is a brief summary of the early background literature about purinergic signalling and its involvement in pain, of ATP storage, release and ectoenzymatic breakdown and of the current classification of receptor subtypes for purines and pyrimidines. The review then focuses on purinergic mechanosensory transduction involved in visceral, cutaneous and
openaire +3 more sources
An Introduction to Purinergic Receptors [PDF]
, 1981 Adenosine 5′-triphosphate (ATP) was primarily considered as an intracellular energy source for many years. However, during the past fifty years purine nucleotides and nucleosides have been shown to have potent extracellular actions on excitable membranes which may be involved in physiological regulatory processes (Berne, 1963; Burnstock, 1972, 1975 ...
Geoffrey Burnstock, Christine M. Brown
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Purinergic and Glutamatergic Receptors on Astroglia
2014Astroglial cells express many neurotransmitter receptors; the receptors to glutamate and ATP being the most abundant. Here, we provide a concise overview on the expression and main properties of astroglial glutamate receptors (ionotropic receptors represented by AMPA and NMDA subtypes) and metabotropic (mainly mGluR5 and mGluR3 subtypes) and ...
Verkhratsky, A, Burnstock, G
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Current Medicinal Chemistry, 2015
The purinergic receptor P2X7 is highly expressed in immune peripheral and central cells suggesting its important role in numerous diseases characterized by inflammatory processes like cancer, or neurodegenerative pathologies in relation with modulation ...
Davy Baudelet +3 more
semanticscholar +1 more source
The purinergic receptor P2X7 is highly expressed in immune peripheral and central cells suggesting its important role in numerous diseases characterized by inflammatory processes like cancer, or neurodegenerative pathologies in relation with modulation ...
Davy Baudelet +3 more
semanticscholar +1 more source
Purinergic (P2) Receptors in the Kidney
2003Publisher Summary This chapter focuses on renal P2 receptors and their relationship to the renal effects of adenosine triphosphate (ATP). It also focuses on the nonvascular P2 receptors of renal epithelia. The effects of adenosine on renal function, the distribution of its P1 (A 1–3 subtypes) receptors in kidney tissue, and the potential of this ...
Leipziger, J., Bailey, M.A., Unwin, R.J.
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Agonists and Antagonists for Purinergic Receptors
2019Membrane receptors that are activated by the purine nucleoside adenosine (adenosine receptors) or by purine or pyrimidine nucleotides (P2Y and P2X receptors) transduce extracellular signals to the cytosol. They play important roles in physiology and disease. The G protein-coupled adenosine receptors comprise four subtypes: A1, A2A, A2B, and A3.
Vigneshwaran Namasivayam +2 more
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