Results 61 to 70 of about 117 (117)

P2Y14 receptor activation of platelets induces Ca2+ mobilization and Rho‐GTPase‐dependent motility that requires an interaction with P2Y1 receptors

British Journal of Pharmacology, Volume 182, Issue 13, Page 2950-2967, July 2025.
Background and Purpose Platelet function during inflammation is dependent on activation by endogenous nucleotides acting on purinergic receptors. The P2Y14 receptor has been reported to be expressed on platelets and is involved in leukocyte recruitment during inflammation.
Md Monir Hossain, Dingxin Pan, Kate L. Arkless, Khondaker Miraz Rahman, Clive P. Page, Kalwant S. Authi, Simon C. Pitchford   +6 more
wiley   +1 more source

Terpene Hydroperoxides as Lipid Peroxidation Inducers: Biomimetic and HaCaT Cell Studies in Allergic Contact Dermatitis

Contact Dermatitis, Volume 93, Issue 1, Page 16-30, July 2025.
Fragrance terpene hydroperoxides from limonene, linalool, and geraniol induced the formation of lipid peroxidation products when incubated with PLPC liposomes or in vitro with HaCaT keratinocytes. Lipid peroxidation products included aldehydes, ketones, and hydroperoxides.
Aaron I. Moore, Ana S. P. Moreira, Tiago Conde, Tânia Melo, Pedro Domingues, Niamh M. O'Boyle, M. Rosário Domingues   +6 more
wiley   +1 more source

It's Time to Unite: Diversity and Coordination of Thymic Stromal Cells for T Cell Selection and Organ Integrity

Immunological Reviews, Volume 332, Issue 1, July 2025.
ABSTRACT The thymus is a primary lymphoid organ for generating a diverse yet self‐tolerant T cell repertoire. Among the thymic stromal cells that create the thymic microenvironment, thymic epithelial cells (TECs) have received the most attention because of their distinctive functions in the repertoire selection of T cells. Other types of thymic stromal
Ryunosuke Muro, Takeshi Nitta
wiley   +1 more source

SOAT1 Activates NLRP3 Inflammasome to Promote Cancer‐Related Lymphangiogenesis and Metastasis via IL‐1β/IL‐1R‐1 Axis in Oral Squamous Cell Carcinoma

Molecular Carcinogenesis, Volume 64, Issue 6, Page 1039-1056, June 2025.
ABSTRACT Oral squamous cell carcinoma (OSCC) is a prevalent type of cancer in the head and neck region, significantly impacting patient survival rates and quality of life. Lymph node (LN) metastasis is a lead contributor to the poor prognosis associated with OSCC.
Chengzhi Zhao, Yuhao Wang, Zhishen Jiang, Shengzhao Guo, Liru Hu, Jian Pan, Fan Dan   +6 more
wiley   +1 more source

Activation of Adenosine Phosphate Signaling Promotes Antitumor Immunity in Tumor Microenvironment and Facilitate Immunotherapy

MedComm – Oncology, Volume 4, Issue 2, June 2025.
A comprehensive analysis of the purinergic signaling mediated by P2 receptors (P2Rs) was conducted at both bulk, single‐cell, and spatial transcriptomic levels, evaluating the prognostic and predictive value of the adenosine signaling pathway in cancer immunotherapy.
Yantao Xu, Ying Wang, Zixi Jiang, Yi He, Guowei Zhou, Benliang Wei, Jiachen Liu, Xiang Chen   +7 more
wiley   +1 more source

Astaxanthin Alleviates Lung Injury by Regulating Oxidative Stress, Inflammatory Response, P2X7 Receptor, NF‐κB, Bcl‐2, and Caspase‐3 in LPS‐Induced Endotoxemia

Environmental Toxicology, Volume 40, Issue 6, Page 924-934, June 2025.
ABSTRACT Sepsis remains the leading cause of multiple‐organ injury due to endotoxemia. Astaxanthin (ASTA), widely used in marine aquaculture, has an extraordinary potential for antioxidant and anti‐inflammatory activity. Purinergic receptor (e.g., P2X7R) activation is a powerful signaling in the modulation of inflammation.
Seckin Ozkanlar, Yunusemre Ozkanlar, Adem Kara, Elif Dalkilinc   +3 more
wiley   +1 more source

SorCS2 Is Important for Astrocytic Function in Neurovascular Signaling

Acta Physiologica, Volume 241, Issue 6, June 2025.
ABSTRACT Introduction The receptor SorCS2 is involved in the trafficking of membrane receptors and transporters. It has been implicated in brain disorders and has previously been reported to be indispensable for ionotropic glutamatergic neurotransmission in the hippocampus.
Christian Staehr, Hande Login, Elizaveta V. Melnikova, Magdalena Bakun, Ewelina Ziemlinska, Lilian Kisiswa, Simin Berenji Ardestani, Stella Solveig Nolte, Hans Christian Beck, Line Mathilde Brostrup Hansen, Dmitry Postnov, Alexei Verkhratsky, Anna R. Malik, Anders Nykjaer, Vladimir V. Matchkov   +14 more
wiley   +1 more source

Blockade of P2X7 receptors preserves blood retinal barrier integrity by modulating the plasmalemma vesicle‐associated protein: Implications for diabetic retinopathy

British Journal of Pharmacology, Volume 182, Issue 12, Page 2603-2620, June 2025.
Background and Purpose Plasmalemma vesicle‐associated protein (PLVAP) regulates transcytosis in vascular endothelial cells. PLVAP expression is increased in pathological conditions, such as diabetic retinopathy. P2X7 receptor antagonists have been shown to preserve blood‐retinal barrier (BRB) integrity.
Chiara Bianca Maria Platania, Francesca Lazzara, Kenneth Mitton, Naomi Haque, Wendelin Dailey, Federica Conti, Erika Giuffrida, Filippo Drago, Anca Hermenean, Cornel Balta, Hildegard Herman, Alina Ciceu, Maria Consiglia Trotta, Michele D'Amico, Giuseppe Nicosia, Settimio Rossi, Claudio Bucolo   +16 more
wiley   +1 more source

Neural Metabolic Networks: Key Elements of Healthy Brain Function

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
This review originated from the Fourth International Society for Neurochemistry (ISN) and Journal of Neurochemistry (JNC) Flagship School (2022). Here, we describe how the specific bioenergetic profiles and metabolic exchanges between brain cells enable and gate synaptic function and behavior. Then, based on this analysis, we discuss the potential role
Nimrod Madrer, Nirma D. Perera, Nonthué A. Uccelli, Alice Abbondanza, Jens V. Andersen, Emma Veronica Carsana, Matthew D. Demmings, Regina F. Fernandez, Matheus Garcia de Fragas, Ismail Gbadamosi, Divita Kulshrestha, Ricardo A. S. Lima‐Filho, Oana C. Marian, Kia H. Markussen, Andrew J. McGovern, Elliott S. Neal, Sukanya Sarkar, Eva Šimončičová, Jazmín Soto‐Verdugo, Sozerko Yandiev, Ignacio Fernández‐Moncada   +20 more
wiley   +1 more source

Diet‐Induced Obesity Blunts Sensitivity of Intestinal Enteric Neurons: FIRST Evidence of Modulation of Activity of Enteric Neurons by Luminal Nutrients

The FASEB Journal, Volume 39, Issue 9, 15 May 2025.
The enteric nervous system (ENS) regulates critical physiological functions including gut motility, blood flow, and epithelial secretions. However, given the anatomical disadvantage of not contacting the lumen, its role in direct luminal sensing has been precluded.
Ava Grandberry, Naomi Rajesh, Robert Murphy, Sinju Sundaresan   +3 more
wiley   +1 more source