Results 61 to 70 of about 2,359,528 (327)

Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells [PDF]

, 2008
Purinergic signalling is important both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling.
Burnstock, G
core  

Extracellular ATP drives systemic inflammation, tissue damage and mortality [PDF]

, 2014
Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of ...
Brouckaert, Peter, Cauwels, Anje, Rogge, Elke, Shiva, S, Vandendriessche, Benjamin   +4 more
core   +1 more source

De Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems

Advanced Science, EarlyView.
EGF‐induced de novo transcription of connexins Cx26 and Cx31 promotes flocking behavior that fluidizes epithelia and enables coordinated collective migration. Connexin‐driven cytoplasmic exchange mechanistically links growth‐factor signaling to invasive dynamics.
Hind Abdo, Leonardo Barzaghi, Yuan Shen, Edoardo Bellini, Emanuele Martini, Serena Magni, Sara Barozzi, Fabrizio Orsenigo, Dario Parazzoli, Galina V. Beznoussenko, Jasmin Di Franco, Fabian Krautgasser, Jasmin Kaivola, Mario Cinquanta, Alessandro Lazzarin, Sara Sigismund, Johanna Ivaska, Roberto Cerbino, Giorgio Scita   +18 more
wiley   +1 more source

Changes in P2Y Purinergic Receptor Expression in the Ciliary Body in a Murine Model of Glaucoma

Frontiers in Pharmacology, 2017
Glaucoma is a neuropathology, often accompanied by an elevated intraocular pressure (IOP), which can lead to blindness. Since DBA/2J mice develop glaucoma, several studies of the physiopathology of glaucoma have been reported in this animal model.
Begoña Fonseca, Alejandro Martínez-Águila, María J. Pérez de Lara, Maria Teresa Miras-Portugal, Rosa Gómez-Villafuertes, Jesús Pintor   +5 more
doaj   +1 more source

Diabetes-induced alterations in urothelium function:Enhanced ATP release and nerve-evoked contractions in the streptozotocin rat bladder [PDF]

, 2018
Up to 80% of patients with diabetes mellitus develop lower urinary tract complications, most commonly diabetic bladder dysfunction (DBD). The aim of this study was to investigate the impact of diabetes on the function of the inner bladder lining ...
Apodaca, Birder, Birder, Brown, Chaiyaprasithi, Cheng, Cheng, Cho, Daly, Daneshgari, Daneshgari, Daneshgari, Dunning-Davies, Eika, Ferguson, Fovaeus, Frimodt-Moller, Golbidi, Gomez, Hanna-Mitchell, Hanna-Mitchell, Hawthorn, Kang, Knight, Kolta, Kumar, Kumar, Lai, Langdale, Liu, Liu, Longhurst, Malmgren, Mumtaz, Munoz, Munoz, Mustafa, Nirmal, Pinna, Ren, Sadananda, Sellers, Silva-Ramos, Smith, Stella, Sun, Tammela, Templeman, Vahabi, Vahabi, Vlaskovska, Wang, Xiao, Xiao, Yoshida, Yoshimura, Zhao   +56 more
core   +1 more source

Purinergic P2X7 Receptor: A Cation Channel Sensitive to Tumor Microenvironment.

Recent Patents on Anti-Cancer Drug Discovery, 2019
BACKGROUND Purinergic signalling is involved in several physiological and pathophysiological processes. P2X7 Receptor (P2X7R) is a calcium-permeable ion channel that is gaining interest as a potential therapeutic target for the treatment of different ...
Giorgia Scarpellino, T. Genova, L. Munaron   +2 more
semanticscholar   +1 more source

Purines, Purinergic Receptors, and Cancer [PDF]

Cancer Research, 2012
AbstractPurines were long thought to be restricted to the intracellular compartment, where they are used for energy transactions, nucleic acid synthesis, and a multiplicity of biochemical reactions. However, it is now clear that both adenosine and adenosine triphosphate are (i) abundant biochemical components of the tumor microenvironment, (ii) potent ...
openaire   +3 more sources

Polydatin alleviates mitochondrial damage and apoptosis of lung epithelial cells by inhibiting toll‐like receptor 4‐dependent macrophage activation in asthma

Animal Models and Experimental Medicine, EarlyView.
The alleviation of asthma by polydatin is dependent on the blockage of the toll‐like receptor 4 (TLR4)/P2X7R synergy in macrophages. The blockage of the TLR4/P2X7R synergy results in decreased release and secretion of interleukin‐1β (IL‐1β) and IL‐18. In epithelial cells, low IL‐1β and IL‐18 levels inhibit mitochondrial damage and apoptosis.
Guangxing Li, Ruobai Liu, Chang Xu, Jianing Yang, Yilan Song, Li Li, Jingzhi Jiang, Liangchang Li, Chongyang Wang, Guanghai Yan   +9 more
wiley   +1 more source

Purinergic Signalling: Therapeutic Developments

Frontiers in Pharmacology, 2017
Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990’s when receptor subtypes for purines and pyrimidines were cloned and ...
Geoffrey Burnstock, Geoffrey Burnstock
doaj   +1 more source

Purinergic signaling via P2X receptors and mechanisms of unregulated ATP release in the outer retina and age-related macular degeneration

Frontiers in Neuroscience, 2023
Age-related macular degeneration (AMD) is a chronic and progressive inflammatory disease of the retina characterized by photoceptor loss and significant central visual impairment due to either choroidal neovascularization or geographic atrophy.
Haydn Molcak, Kailun Jiang, Christopher J. Campbell, Joanne A. Matsubara   +3 more
doaj   +1 more source