Results 61 to 70 of about 2,316,796 (350)

Purinergic Signaling During Hyperglycemia in Vascular Smooth Muscle Cells

Frontiers in Endocrinology, 2020
The activation of purinergic receptors by nucleotides and/or nucleosides plays an important role in the control of vascular function, including modulation of vascular smooth muscle excitability, and vascular reactivity.
Miguel Martin-Aragon Baudel, Ricardo Espinosa-Tanguma, Madeline Nieves-Cintron, Manuel F. Navedo   +3 more
doaj   +1 more source

The purinergic receptor subtype P2Y2 mediates chemotaxis of neutrophils and fibroblasts in fibrotic lung disease

OncoTarget, 2017
Idiopathic pulmonary fibrosis (IPF) is a devastating disease with few available treatment options. Recently, the involvement of purinergic receptor subtypes in the pathogenesis of different lung diseases has been demonstrated.
T. Müller, S. Fay, R. Vieira, H. Karmouty-quintana, S. Cicko, Korcan Ayata, G. Zissel, T. Goldmann, G. Lungarella, D. Ferrari, F. Di Virgilio, B. Robaye, J. Boeynaems, M. Blackburn, M. Idzko   +14 more
semanticscholar   +1 more source

Understanding the role of P2X7 in affective disorders—are glial cells the major players? [PDF]

, 2015
Pathophysiology associated with several psychiatric disorders has been linked to inflammatory biomarkers. This has generated a theory of major depressive disorders as an inflammatory disease.
Jenkins, Trisha A., Spencer, Sarah J., Stokes, Leanne   +2 more
core   +2 more sources

Graft‐Infiltrating Macrophages Adopt an M2 Phenotype and Are Inhibited by Purinergic Receptor P2X7 Antagonist in Chronic Rejection

American Journal of Transplantation, 2016
Macrophages exhibit diverse phenotypes and functions; they are also a major cell type infiltrating chronically rejected allografts. The exact phenotypes and roles of macrophages in chronic graft loss remain poorly defined. In the present study, we used a
Chenglin Wu, Yue Zhao, Xiang Xiao, Yihui Fan, M. Kloc, W. Liu, R. Ghobrial, Peixiang Lan, Xiaoshun He, Xian Chang Li   +9 more
semanticscholar   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes [PDF]

, 2008
ATP plays an important role in signal transduction between neuronal and glial circuits and within glial networks. Here we describe currents activated by ATP in astrocytes acutely isolated from cortical brain slices by non-enzymatic mechanical ...
Kirchhoff, Frank, Lalo, Ulyana, North, R. Alan, Pankratov, Yuriy, Rossner, Moritz J., Verkhratskiĭ, A. N. (Alekseĭ Nestorovich), Wichert, Sven P.   +6 more
core   +1 more source

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source

Traditional Chinese medicine alleviating neuropathic pain targeting purinergic receptor P2 in purinergic signaling: A review

Brain Research Bulletin, 2023
Past studies have suggested that Chinese herbal may alleviate neuropathic pain, and the mechanism might target the inhibition of purinergic receptor P2.
Bo Yang, Nengwei Yu
doaj  

Purinergic Signalling: Therapeutic Developments

Frontiers in Pharmacology, 2017
Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990’s when receptor subtypes for purines and pyrimidines were cloned and ...
Geoffrey Burnstock, Geoffrey Burnstock
doaj   +1 more source

Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells [PDF]

, 2008
Purinergic signalling is important both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling.
Burnstock, G
core