Purine and purinergic receptors in health and disease [PDF]
MedComm, 2023 Purines and purinergic receptors are widely distributed throughout the human body. Purine molecules within cells play crucial roles in regulating energy metabolism and other cellular processes, while extracellular purines transmit signals through ...
Yanling Ai +6 more
doaj +3 more sources
Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma? [PDF]
Frontiers in Allergy, 2021 Extracellular ATP functions as a signaling messenger through its actions on purinergic receptors, and is known to be involved in numerous physiological and pathophysiological processes throughout the body, including in the lungs and airways. Consequently,
Rebecca J. Thompson +3 more
doaj +3 more sources
Purinergic receptors are a key bottleneck in tumor metabolic reprogramming: The prime suspect in cancer therapeutic resistance [PDF]
Frontiers in Immunology, 2022 ATP and other nucleoside phosphates have specific receptors named purinergic receptors. Purinergic receptors and ectonucleotidases regulate various signaling pathways that play a role in physiological and pathological processes.
Hamid Aria +11 more
doaj +3 more sources
The Role of Microglial Purinergic Receptors in Pain Signaling [PDF]
Molecules, 2022 Pain is an essential modality of sensation in the body. Purinergic signaling plays an important role in nociceptive pain transmission, under both physiological and pathophysiological conditions, and is important for communication between both neuronal ...
Hidetoshi Tozaki-Saitoh +2 more
doaj +3 more sources
Purinergic receptors in cognitive disturbances
Neurobiology of Disease, 2023 Purinergic receptors (Rs) of the ATP/ADP, UTP/UDP (P2X, P2Y) and adenosine (A1, A2A)-sensitive classes broadly interfere with cognitive processes both under quasi normal and disease conditions.
Peter Illes +3 more
doaj +4 more sources
Purinergic receptors mediate endothelial dysfunction and participate in atherosclerosis. [PDF]
Purinergic Signal, 2023 Atherosclerosis is the main pathological basis of cardiovascular disease and involves damage to vascular endothelial cells (ECs) that results in endothelial dysfunction (ED).
Wu XM +5 more
europepmc +2 more sources
Targeting purinergic receptors to attenuate inflammation of dry eye. [PDF]
Purinergic Signal, 2023 Inflammation is one of the potential factors to cause the damage of ocular surface in dry eye disease (DED). Increasing evidence indicated that purinergic A_1, A_2A, A_3, P2X4, P2X7, P2Y_1, P2Y_2, and P2Y_4 receptors play an important role in the ...
Wang JN, Fan H, Song JT.
europepmc +2 more sources
Control of Macrophage Inflammation by P2Y Purinergic Receptors. [PDF]
Cells, 2021 Macrophages comprise a phenotypically and functionally diverse group of hematopoietic cells. Versatile macrophage subsets engage to ensure maintenance of tissue integrity.
Klaver D, Thurnher M.
europepmc +2 more sources
Purinergic Receptors of the Central Nervous System: Biology, PET Ligands, and Their Applications
Molecular Imaging, 2020 Purinergic receptors play important roles in central nervous system (CNS). These receptors are involved in cellular neuroinflammatory responses that regulate functions of neurons, microglial and astrocytes.
Hamideh Zarrinmayeh PhD +1 more
doaj +2 more sources
Purine and purinergic receptors [PDF]
Brain and Neuroscience Advances, 2018 Adenosine 5′-triphosphate acts as an extracellular signalling molecule (purinergic signalling), as well as an intracellular energy source. Adenosine 5′-triphosphate receptors have been cloned and characterised. P1 receptors are selective for adenosine, a breakdown product of adenosine 5′-triphosphate after degradation by ectonucleotidases.
G. Burnstock
openaire +3 more sources