Purine and purinergic receptors in health and disease [PDF]
MedComm, 2023 Purines and purinergic receptors are widely distributed throughout the human body. Purine molecules within cells play crucial roles in regulating energy metabolism and other cellular processes, while extracellular purines transmit signals through ...
Yanling Ai +6 more
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Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma? [PDF]
Frontiers in Allergy, 2021 Extracellular ATP functions as a signaling messenger through its actions on purinergic receptors, and is known to be involved in numerous physiological and pathophysiological processes throughout the body, including in the lungs and airways. Consequently,
Rebecca J. Thompson +3 more
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Purinergic receptors in airway hydration. [PDF]
Biochem Pharmacol, 2021 Airway epithelial purinergic receptors control key components of the mucociliary clearance (MCC), the dominant component of pulmonary host defense. In healthy airways, the periciliary liquid (PCL) is optimally hydrated, thus acting as an efficient lubricant layer over which the mucus layer moves by ciliary force.
Lazarowski ER, Boucher RC.
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Changes in P2Y Purinergic Receptor Expression in the Ciliary Body in a Murine Model of Glaucoma [PDF]
Frontiers in Pharmacology, 2017 Glaucoma is a neuropathology, often accompanied by an elevated intraocular pressure (IOP), which can lead to blindness. Since DBA/2J mice develop glaucoma, several studies of the physiopathology of glaucoma have been reported in this animal model.
Begoña Fonseca +5 more
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Purinergic receptors are a key bottleneck in tumor metabolic reprogramming: The prime suspect in cancer therapeutic resistance [PDF]
Frontiers in Immunology, 2022 ATP and other nucleoside phosphates have specific receptors named purinergic receptors. Purinergic receptors and ectonucleotidases regulate various signaling pathways that play a role in physiological and pathological processes.
Hamid Aria +11 more
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The Role of Microglial Purinergic Receptors in Pain Signaling [PDF]
Molecules, 2022 Pain is an essential modality of sensation in the body. Purinergic signaling plays an important role in nociceptive pain transmission, under both physiological and pathophysiological conditions, and is important for communication between both neuronal ...
Hidetoshi Tozaki-Saitoh +2 more
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Purinergic signalling: past, present and future [PDF]
Brazilian Journal of Medical and Biological Research, 2009 The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's.
G. Burnstock
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Alterations of Purinergic Receptors Levels and Their Involvement in the Glial Cell Morphology in a Pre-Clinical Model of Autism Spectrum Disorders [PDF]
Brain Sciences, 2023 Recent data suggest that defects in purinergic signalling are a common denominator of autism spectrum disorders (ASDs), though nothing is known about whether the disorder-related imbalance occurs at the receptor level.
Lidia Babiec +5 more
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Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation. [PDF]
Purinergic Signal, 2023 Kiaie SH +6 more
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Purinergic Receptors in Dendritic Cells [PDF]
Journal of Inflammation ResearchMiaomiao Wang,1 Xiaoxiao Zhao,1 Shuai Hou,1 Zhongbo Wu,2 Hai-yan Yin1 1School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China; 2Brain Disease Research Center, Tongren People’s ...
Wang M, Zhao X, Hou S, Wu Z, Yin HY
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