The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2. [PDF]
Curr Opin Pharmacol, 2023 Hernandez CA, Eugenin EA.
europepmc +1 more source
Molecular Mechanisms of Chronic Pain and Therapeutic Interventions
MedComm, Volume 6, Issue 8, August 2025.We offer a comprehensive overview of the distinctive molecular mechanisms underlying nociceptive, neuropathic, and nociplastic pain, including the immune responses, ion channels, monoaminergic imbalance, and neuroinflammation. Subsequently, we summarized the status quo of nociceptive, neuropathic, and nociplastic pain managementmanipulation.
Zhen Li +8 more
wiley +1 more source
Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R. [PDF]
Protein Cell, 2023 Li B +8 more
europepmc +1 more source
Coronary Microvascular Dysfunction in Ischaemic Heart Disease: Lessons From Large Animal Models
Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 2, August 2025.ABSTRACT The coronary microvasculature is principally responsible for matching coronary blood flow to myocardial demand of oxygen and nutrients. Short‐term control of coronary blood flow is achieved via alterations in coronary microvascular tone, whereas long‐term control of coronary flow also involves remodelling of the coronary microvasculature ...
Oana Sorop +3 more
wiley +1 more source
Voiding Behavior and Efferent Bladder Function Altered in Mice Following Social Defeat but Not Witness Trauma [PDF]
, 2020 Chess-Williams, Russ +3 more
core +1 more source
ROLE OF PURINERGIC RECEPTORS IN IMMUNE RESPONSE
Journal of microbiology, epidemiology and immunobiology, 2016 Purine receptors are located on immune and somatic cells of animal and human organisms. Summation of signals from purine and TOLL-like receptors takes place on the level of inflammasome formation and results in summation of the first and second signals of innate immunity.
openaire +5 more sources
Identification of Amino Acid Residues Contributing to the ATP-binding Site of a Purinergic P2X Receptor [PDF]
, 2000 Lin‐Hua Jiang +3 more
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British Journal of Pharmacology, Volume 182, Issue 16, Page 3800-3817, August 2025.Background and Purpose Nimodipine, an L‐type voltage‐gated calcium channel blocker, is an approved cerebral vasorelaxant. We hypothesized that nimodipine attenuates the pro‐inflammatory shift in microglial phenotypes. Here, we analysed the effects of nimodipine on morphological and functional microglial phenotypes as well as their transcriptomic ...
István Pesti +10 more
wiley +1 more source
Modulation of Interleukin-1β and Tumor Necrosis Factor α Signaling by P2 Purinergic Receptors in Human Fetal Astrocytes [PDF]
, 2000 Judy S. H. Liu +4 more
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The human colon: Evidence for degenerative changes during aging and the physiological consequences
Neurogastroenterology &Motility, Volume 37, Issue 8, August 2025.Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley +1 more source