Results 31 to 40 of about 44,347 (208)
Advanced Science, EarlyView.Y332D, a bispecific antibody that simultaneously blockades VEGF and TGF‐β, counteracted negative RT effects that are attributed to the upregulation of TGF‐β and VEGF, as well as further enhanced the immunostimulatory effects of RT, thereby reprograming the TME from immune “cold” to inflamed state and forming an effective in‐situ vaccine that eradicate ...
Lijuan Lyu +13 more
wiley +1 more source
Resetting intrinsic purinergic modulation of neural activity: an associative mechanism? [PDF]
, 2002 The purines, ATP and adenosine, control the rundown and termination of swimming in the Xenopus embryo. This intrinsic purinergic modulation, unavoidably present during every swimming episode, could lead to stereotyped inflexible behavior and consequently
Dale, Nicholas
core +1 more source
Blood DDIT4 and TRIM13 Transcript Levels Mark the Early Stages of Machado–Joseph Disease
Annals of Neurology, EarlyView.Objective An abundance of select transcripts and proteins has been found to be dysregulated in blood samples of Machado–Joseph disease (MJD) carriers. Here, we aimed to: (1) identify blood transcriptional changes as potential biomarkers of MJD; (2) correlate levels of differentially expressed blood transcripts with MJD carriers features; and (3 ...
Ana F. Ferreira +10 more
wiley +1 more source
Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells [PDF]
, 2008 Purinergic signalling is important both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling.
Burnstock, G
core
Gout and NLRP3 inflammasome biology
Arthritis &Rheumatology, Accepted Article.This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilisation, and self‐resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal‐induced inflammation is reviewed in detail.
Raewyn Poulsen, Nicola Dalbeth
wiley +1 more source
Purinergic receptors on blood platelets
Platelets, 1996 Extracellular adenine nucleotides interact with P2 purinergic receptors to regulate a broad range of physiological processes among which platelet aggregation P2 purinoceptors were divided into two main groups: the G-protein coupled receptor or 'metabotropic' superfamily termed P2Y and the ligand-gated ion channel or 'ionotropic receptor' superfamily ...
J P Cazenave +5 more
openaire +3 more sources
Characterization of ionotrophic purinergic receptors in hepatocytes [PDF]
Hepatology, 2008 Ionotrophic purinergic (P2X) receptors function as receptor-gated cation channels, where agonist binding leads to opening of a nonselective cation pore permeable to both Na+ and Ca2+. Based on evidence that extracellular adenosine 5′-triphosphate (ATP) stimulates glucose release from liver ...
Gordan Kilic +8 more
openaire +4 more sources
The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]
, 2013 Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Birch, Rebecca E +3 more
core +3 more sources
Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis
BMEMat, EarlyView.This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang +6 more
wiley +1 more source
The role of the purinergic P2X7 receptor in inflammation [PDF]
Journal of Inflammation, 2007 AbstractThe inflammatory process, orchestrated against a variety of injurious stimuli, is composed of three inter-related phases; initiation, propagation and resolution. Understanding the interplay between these three phases and harnessing the beneficial properties of inflammation whilst preventing its damaging effects, will undoubtedly lead to the ...
Lister, Martin F +6 more
openaire +5 more sources