Results 91 to 100 of about 44,593 (226)
Purinergic signaling during Porphyromonas gingivalis infection
Biomedical Journal, 2016 Despite recent advances unraveling mechanisms of hostâpathogen interactions in innate immunity, the participation of purinergic signaling in infection-driven inflammation remains an emerging research field with many unanswered questions.
Cássio Luiz Coutinho Almeida-da-Silva +4 more
doaj +1 more source
The trafficking and targeting of P2X receptors [PDF]
, 2013 The functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ in their subcellular distributions because they have very ...
Murrell-Lagnado, Ruth D +1 more
core +3 more sources
Bradykinin increases resensitization of purinergic receptor signaling in glioma cells
Cancer Cell International, 2010 Background Purinergic receptor-mediated signaling plays an important role in the function of glial cells, including glial tumor cells. Bradykinin is also an important paracrine mediator which is highly expressed in brain tumors and may correlate with ...
Brennan Kevin C +3 more
doaj +1 more source
Matrix metalloproteinases, purinergic signaling, and epigenetics, hubs in the spinal neuroglial network following nerve injury. [PDF]
, 2021 Ciro De Luca +6 more
openalex +1 more source
Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms
Cell Proliferation, EarlyView.Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng +4 more
wiley +1 more source
Mechanisms of astrocytic and microglial purinergic signaling in homeostatic regulation and implications for neurological disease [PDF]
Exploration of NeurosciencePurinergic signaling, mediated by ATP and adenosine receptors, plays a crucial role in cellular communication and homeostasis within the central nervous system (CNS), particularly by regulating synaptic activity, glial cell functions, and neuroplasticity.
Moawiah M Naffaa
doaj +1 more source
Epilepsia, EarlyView.Abstract Epilepsy affects approximately 1% of the population worldwide, and although medications are effective in the majority of cases, seizures persist in approximately 30% of patients. Despite the effort to develop new antiseizure drugs, the rate of pharmacoresistance in patients has not diminished over the past 3 decades. There is thus a real unmet
Vincent Magloire +9 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective Studies in temporal lobe epilepsy (TLE) have shown that focal inflammation is a key contributor to seizure initiation and maintenance. However, most in vivo studies to date have focused on positron emission tomography (PET) findings. In this exploratory study, we assessed the relationship between multicompartment Neurite Orientation ...
Jerzy P. Szaflarski +6 more
wiley +1 more source
Extracellular ATP triggers proteolysis and cytosolic Ca²⁺ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites. [PDF]
, 2012 BACKGROUND: Plasmodium has a complex cell biology and it is essential to dissect the cell-signalling pathways underlying its survival within the host. METHODS: Using the fluorescence resonance energy transfer (FRET) peptide substrate Abz-AIKFFARQ-EDDnp ...
Blackman, Michael J +6 more
core +4 more sources