Results 181 to 190 of about 26,356 (209)
Some of the next articles are maybe not open access.
Purinergic Signalling and Endothelium
Current Vascular Pharmacology, 2016Purinergic signalling is involved in the control of vascular tone and remodelling. Endothelial cells release purines and pyrimidines in response to changes in blood flow (evoking shear stress) and hypoxia. They then act on P2Y, P2X and P1 receptors on endothelial cells leading to release of EDRF mediated by nitric oxide and prostaglandins and EDHF ...
openaire +2 more sources
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012
AbstractThe concept of purinergic neurotransmission was proposed in 1972, after it was shown that adenosine 5′‐triphosphate (ATP) was a transmitter in non‐adrenergic, non‐cholinergic inhibitory nerves in the guinea pig taenia coli. Subsequently, ATP was identified as a cotransmitter in sympathetic and parasympathetic nerves, and it is now recognized ...
Burnstock, G. +1 more
openaire +2 more sources
AbstractThe concept of purinergic neurotransmission was proposed in 1972, after it was shown that adenosine 5′‐triphosphate (ATP) was a transmitter in non‐adrenergic, non‐cholinergic inhibitory nerves in the guinea pig taenia coli. Subsequently, ATP was identified as a cotransmitter in sympathetic and parasympathetic nerves, and it is now recognized ...
Burnstock, G. +1 more
openaire +2 more sources
Signaling at Purinergic P2X Receptors
Annual Review of Physiology, 2009P2X receptors are membrane cation channels gated by extracellular ATP. Seven P2X receptor subunits (P2X1-7) are widely distributed in excitable and nonexcitable cells of vertebrates. They play key roles in inter alia afferent signaling (including pain), regulation of renal blood flow, vascular endothelium, and inflammatory responses.
Surprenant, Annmarie, Alan North, R.
openaire +3 more sources
Purinergic Signalling in the Gut
2016The article will begin with the discovery of purinergic inhibitory neuromuscular transmission in the 1960s/1970s, the proposal for purinergic cotransmission in 1976 and the recognition that sympathetic nerves release adenosine 5'-triphosphate (ATP), noradrenaline and neuropeptide Y, while non-adrenergic, non-cholinergic inhibitory nerve cotransmitters ...
openaire +2 more sources
Purinergic signaling in diabetes and metabolism
Biochemical Pharmacology, 2021Purinergic signaling, a concept originally formulated by the late Geoffrey Burnstock (1929-2020), was found to modulate pathways in every physiological system. In metabolic disorders there is a role for both adenosine receptors and P2 (nucleotide) receptors, of which there are two classes, i.e. P2Y metabotropic and P2X ionotropic receptors.
Shanu, Jain, Kenneth A, Jacobson
openaire +2 more sources
Purinergic Signaling in Glioma Progression
2012Among the pathological alterations that give tumor cells invasive potential, purinergic signaling is emerging as an important component. Studies performed in in vitro, in vivo and ex vivo glioma models indicate that alterations in the purinergic signaling are involved in the progression of these tumors.
Elizandra, Braganhol +3 more
openaire +3 more sources
Introduction to Purinergic Signaling
2019Purinergic signaling was proposed in 1972, after it was demonstrated that adenosine 5'-triphosphate (ATP) was a transmitter in nonadrenergic, noncholinergic inhibitory nerves supplying the guinea-pig taenia coli. Later, ATP was identified as an excitatory cotransmitter in sympathetic and parasympathetic nerves, and it is now apparent that ATP acts as a
openaire +2 more sources
Purinergic Signalling in the Cerebellum
2016Purinergic signalling is a complex and evolutionarily conserved mechanism of extracellular communication involved in many physiological and pathological functions. The complexity arises from a large number of purine receptor subtypes and multiple endogenous purine receptor ligands (including ATP, ADP, UTP, UDP UDP-glucose and adenosine) which can be ...
openaire +1 more source
Purinergic signalling in brain ischemia
Neuropharmacology, 2016Ischemia is a multifactorial pathology characterized by different events evolving in the time. After ischemia a primary damage due to the early massive increase of extracellular glutamate is followed by activation of resident immune cells, i.e microglia, and production or activation of inflammation mediators.
PEDATA, FELICITA +6 more
openaire +2 more sources
Purinergic signalling and bone remodelling☆
Current Opinion in Pharmacology, 2010Accumulating evidence suggests that extracellular nucleotides, signalling through P2 receptors, could play an important role in modulating bone cell function. ATP and other nucleotides can stimulate the formation and resorptive activity of osteoclasts (bone-destroying cells) in addition to inhibiting bone mineralisation by osteoblasts.
Isabel R, Orriss +2 more
openaire +2 more sources