Results 171 to 180 of about 29,008 (251)

Early Regional Microglial Remodelling in the Hippocampus of the AppNL‐G‐F Alzheimer's Model

Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.
Microglia undergo profound structural and functional changes during Alzheimer's disease, yet the earliest stages of morphological remodelling that occur prior to amyloid deposition remain poorly defined. Through high‐resolution 3D morphometry in the CA1 region of the hippocampus of AppNL‐G‐F mice, it was found that although microglial numbers and ...
Ryan J. Bevan, Jessica F. Minett, Alice L. Smith, Ana Cardus Figueras, Philip R. Taylor   +4 more
wiley   +1 more source

Purinergic signaling in dengue infection: modulation of P2 receptors as a potential therapeutic strategy. [PDF]

Purinergic Signal
de Melo VC, de Oliveira KI, Kipper M, Bagatini MD, da Silva GB.   +4 more
europepmc   +1 more source

Acute Sleep Deprivation Shifts Substrate Utilization Toward Greater Fat Oxidation During Incremental Exercise in Recreationally Trained Adults

Scandinavian Journal of Medicine &Science in Sports, Volume 36, Issue 6, June 2026.
ABSTRACT Sleep deprivation alters metabolic homeostasis and substrate metabolism, but its effect on fat and carbohydrate utilization during exercise is unclear. This study examined the effects of one night of total and partial sleep deprivation on substrate utilization during a maximal fat oxidation test (MFO) in recreationally trained adults.
Marta del Val‐Manzano, Juan Jesús Montalvo‐Alonso, Paola Gonzalo‐Encabo, David Valadés, Carmen Ferragut, Alberto Pérez‐López   +5 more
wiley   +1 more source

Purinergic signaling modulates endothelial-to-mesenchymal transition in human aortic valve endothelial cells. [PDF]

BBA Adv
Schmidt V, Weber A, Lichtenberg A, Schrader J, Martsch P, Barth M, Akhyari P.   +6 more
europepmc   +1 more source

HIF‐Regulated Pannexin‐1 Channel Drives Luminal ATP Accumulation in Kidney Cysts

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Autosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Kathrin Skoczynski, Julia Katharina Scholz, Raluca Ursu, Johannes Schödel, Steffen Grampp, Stephanie Naas, Victoria Lauer, Mario Schiffer, Maike Büttner‐Herold, Bjoern Buchholz, Andre Kraus   +10 more
wiley   +1 more source

Purinergic signaling in osteoarthritis: Mechanistic insights into pathogenesis and therapeutic targeting. [PDF]

Genes Dis
Li H, Wang T, Wang Z, Hou J, Li Z, Yan J.   +5 more
europepmc   +1 more source

Macrophage‐Fibroblast Crosstalk Shapes Wound Repair Signaling In Vitro

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Intercellular communication between macrophages and fibroblasts is critical for wound healing. Macrophages promoted fibroblast scratch closure through contact‐dependent mechanisms independent of connexins. In contrast, fibroblasts regulated macrophage cytokine secretion via connexin‐43–mediated contact signaling that increased IL10 and paracrine ...
Daniela Enriquez‐Ochoa, Raji R. Nagalla, Yingzi Liu, Christian F. Guerrero‐Juarez, Hamza Atcha, Gordon Chang, Nancy A. Morales, Hannah J. Hooper, Arian D. Cano, Huy Eng Lim, Michael D. Cahalan, Maksim V. Plikus, Wendy F. Liu   +12 more
wiley   +1 more source

Purinergic signaling and cholangiocyte regeneration: a new frontier in ischemic liver injury. [PDF]

Front Transplant
Nwaduru C, Anyagwa OE, Fenlon M, Buff M, Selim M, Botha J, Kastenberg Z, Zimmerman M.   +7 more
europepmc   +1 more source

Purinergic Signaling, HIF, and ROS Interactions in Myocardial I/R Injury: Therapeutic Potential and Future Prospective. [PDF]

Cells
Singh MK, Yun HR, Ranbhise J, Han S, Seo H, Yeo SG, Quan FS, Kim SS, Kang I.   +8 more
europepmc   +1 more source

ATP-related purinergic signaling via P2Y12 contributes to airway epithelial barrier integrity. [PDF]

BMC Mol Cell Biol
Tsuya K, Maruoka S, Okamoto S, Shikano S, Ujike M, Yamada S, Kurosawa Y, Mizumura K, Kozu Y, Gon Y.   +9 more
europepmc   +1 more source