Results 51 to 60 of about 4,625,876 (321)

Neonatal Seizures and Purinergic Signalling [PDF]

International Journal of Molecular Sciences, 2020
Neonatal seizures are one of the most common comorbidities of neonatal encephalopathy, with seizures aggravating acute injury and clinical outcomes. Current treatment can control early life seizures; however, a high level of pharmacoresistance remains among infants, with increasing evidence suggesting current anti-seizure medication potentiating brain ...
Menéndez Méndez, Aida, Smith, Jonathon, Engel, Tobias   +2 more
openaire   +3 more sources

Purine and purinergic receptors in health and disease

MedComm, 2023
Purines and purinergic receptors are widely distributed throughout the human body. Purine molecules within cells play crucial roles in regulating energy metabolism and other cellular processes, while extracellular purines transmit signals through ...
Yanling Ai, Hengyi Wang, Lu Liu, Yulin Qi, Shiyun Tang, Jianyuan Tang, Nianzhi Chen   +6 more
doaj   +1 more source

The Potential of Purinergic Signaling to Thwart Viruses Including SARS-CoV-2

Frontiers in Immunology, 2022
A long-shared evolutionary history is congruent with the multiple roles played by purinergic signaling in viral infection, replication and host responses that can assist or hinder viral functions.
Davide Ferrari, Davide Ferrari, Michele Rubini, Jorge S. Burns, Jorge S. Burns   +4 more
doaj   +1 more source

Purinergic Signaling in Controlling Macrophage and T Cell Functions During Atherosclerosis Development

Frontiers in Immunology, 2021
Atherosclerosis is a hardening and narrowing of arteries causing a reduction of blood flow. It is a leading cause of death in industrialized countries as it causes heart attacks, strokes, and peripheral vascular disease.
D. Ferrari, A. la Sala, D. Milani, C. Celeghini, F. Casciano   +4 more
semanticscholar   +1 more source

Ectonucleoside triphosphate diphosphohydrolases and ecto-5′-nucleotidase in purinergic signaling: how the field developed and where we are now

Purinergic Signalling Purinergic Signalling, 2020
Geoffrey Burnstock will be remembered as the scientist who set up an entirely new field of intercellular communication, signaling via nucleotides. The signaling cascades involved in purinergic signaling include intracellular storage of nucleotides ...
H. Zimmermann
semanticscholar   +1 more source

Purinergic Signaling and Inflammasome Activation in Psoriasis Pathogenesis

International Journal of Molecular Sciences, 2021
Psoriasis is a chronic inflammatory disease of the skin associated with systemic and joint manifestations and accompanied by comorbidities, such as metabolic syndrome and increased risk of cardiovascular disease. Psoriasis has a strong genetic basis, but
D. Ferrari, F. Casciano, P. Secchiero, E. Reali   +3 more
semanticscholar   +1 more source

Purinergic Signaling in Pathologic Osteogenic Differentiation of Aortic Valve Interstitial Cells from Patients with Aortic Valve Calcification

Biomedicines, 2023
Purinergic signaling is associated with a vast spectrum of physiological processes, including cardiovascular system function and, in particular, its pathological calcifications, such as aortic valve stenosis.
Polina Klauzen, Daria Semenova, Daria Kostina, Vladimir Uspenskiy, Anna Malashicheva   +4 more
doaj   +1 more source

Purinergic signaling and purine base metabolism at the crossroads between immunity, metabolism, and cancer: A review

ImmunoMedicine, 2023
In addition to its universally known role in transferring genetic material, DNA nucleotides and nucleosides are regarded as the most ancient form of extracellular signaling molecules. This unique signaling pathway was first reported by Dr.
Delaney K. Geitgey, Anja J. Melendez, Raquel Caldeira‐Botelho, Melissa L. Kemp, Curtis J. Henry   +4 more
doaj   +1 more source

Besnoitia besnoiti-induced neutrophil clustering and neutrophil extracellular trap formation depend on P2X1 purinergic receptor signaling

Frontiers in Immunology, 2023
Bovine besnoitiosis is a re-emerging cattle disease caused by the cyst-forming apicomplexan parasite Besnoitia besnoiti. Neutrophil extracellular trap (NET) formation represents an efficient innate immune mechanism of polymorphonuclear neutrophils (PMN ...
Gabriel Espinosa, Iván Conejeros, Lisbeth Rojas-Barón, Carlos Rodrigo Hermosilla, Anja Taubert   +4 more
doaj   +1 more source

Novel possibility for cutaneous melanoma treatment by means of rosmarinic acid action on purinergic signaling

Purinergic Signalling Purinergic Signalling, 2021
Cancer cases have increased significantly in Brazil and worldwide, with cutaneous melanoma (CM) being responsible for nearly 57,000 deaths in the world.
G. B. da Silva, Milena Ayumi Yamauchi, D. Zanini, M. Bagatini   +3 more
semanticscholar   +1 more source