Results 81 to 90 of about 4,625,657 (223)

WONOEP XVII appraisal: Targeting network excitability beyond the synapse ‐Neurotransmitter, ionic, and electro ‐diffusions

Epilepsia, EarlyView.
Abstract Epilepsy affects approximately 1% of the population worldwide, and although medications are effective in the majority of cases, seizures persist in approximately 30% of patients. Despite the effort to develop new antiseizure drugs, the rate of pharmacoresistance in patients has not diminished over the past 3 decades. There is thus a real unmet
Vincent Magloire, Marco de Curtis, Jeffrey Noebels, Gilles Huberfeld, Piotr Suffczynski, Vadym Gnatkovsky, Olga Tyurikova, Dominique Durand, David C. Henshall, Cian McCafferty   +9 more
wiley   +1 more source

The anti-inflammatory astrocyte revealed: the role of the microbiome in shaping brain defences

Signal Transduction and Targeted Therapy, 2021
Alexei Verkhratsky, Peter Illes, Yong Tang, Alexey Semyanov   +3 more
doaj   +1 more source

A Critical Role for Purinergic Signalling in the Mechanisms Underlying Generation of BOLD fMRI Responses

Journal of Neuroscience, 2015
The mechanisms of neurovascular coupling underlying generation of BOLD fMRI signals remain incompletely understood. It has been proposed that release of vasoactive substances by astrocytes couples neuronal activity to changes in cerebrovascular blood ...
J. Wells, Isabel N. Christie, P. Hosford, Robert T. R. Huckstepp, Plamena R. Angelova, P. Vihko, S. Cork, A. Abramov, A. Teschemacher, S. Kasparov, M. Lythgoe, A. Gourine   +11 more
semanticscholar   +1 more source

Lipid regulation of adenylyl cyclase Rv1625c from Mycobacterium tuberculosis by its membrane‐domain receptor

The FEBS Journal, EarlyView.
The adenylyl cyclase (AC) Rv1625c from M. tuberculosis is a monomeric progenitor of the nine pseudoheterodimeric mammalian AC isoforms. The hexahelical membrane anchor of Rv1625c serves as an inhibitory receptor for fatty acids, particularly oleic acid. One ligand binds into each monomer of the active Rv1625c dimer.
Anita Charlotte Friderun Schultz, Marius Landau, Andrei N. Lupas, Joachim Erdmann Schultz   +3 more
wiley   +1 more source

Role of purinergic receptors in the activation of human airway smooth muscle cells by the antimicrobial peptide LL-37

European Respiratory Review, 2006
Inflammatory cells that infiltrate and surround the airway smooth muscle (ASM) layer express antimicrobial peptides including the cathelicidin LL-37.
Suzanne Zuyderduyn, Dennis. K. Ninaber, Pieter. S. Hiemstra, Klaus. F. Rabe   +3 more
doaj  

Purinergic Signalling in Physiology and Pathophysiology. [PDF]

Int J Mol Sci, 2023
Sluyter R.
europepmc   +1 more source

Non‐ionotropic NMDAR signalling activates Panx1 to induce P2X4R‐dependent long‐term depression in the hippocampus

The Journal of Physiology, EarlyView.
Abstract figure legend Stimulation of the Shaffer collateral pathway at 3 Hz activates non‐ionotropic NMDA receptors. This subsequently leads to Src kinase mediated phosphorylation of pannexin‐1 (Panx1), which releases ATP from the postsynaptic cell. ATP acts as a ligand for P2X4 receptors to induce long‐term depression (LTD). Abstract In recent years,
Allison C. Nielsen, Connor L. Anderson, Carina Ens, Andrew K. J. Boyce, Roger J. Thompson   +4 more
wiley   +1 more source

Editorial: Purinergic signalling - a perspective from China. [PDF]

Purinergic Signal, 2023
Tang Y, Chen JF, Illes P.
europepmc   +1 more source

Recent advances in the structure, function and regulation of the volume‐regulated anion channels and their role in immunity

The Journal of Physiology, EarlyView.
Abstract figure legend The volume‐regulated anion channel (VRAC), composed of leucine‐rich repeat‐containing 8 (LRRC8) proteins, serves both canonical and non‐canonical functions in vertebrate cells. The canonical function of this channel relates to its original description, which is homeostatic regulation of cell volume in response to hypotonic ...
Sergei Yanushkevich, Aleksandra Zieminska, Joshua Gonzalez, Francisca Añazco, Richard Song, Alejandra Arias‐Cavieres, Sara T. Granados, Junyi Zou, Yan Rao, Axel R. Concepcion   +9 more
wiley   +1 more source

Beneficial effect of electroacupuncture on the distribution of foreign substances in the brain of rats developing depression-like behavior

IBRO Neuroscience Reports, 2023
We used low and high molecular weight fluorescence tracers to investigate the entry of foreign solutes into the brain parenchyma and their exit from it by the glymphatic system, during experimentally induced depressive-like behavior in rats.
Jin-Rong He, Patrizia Rubini, Bao-Man Li, Hai-Yan Yin, Yong Tang, Peter Illes   +5 more
doaj