Results 51 to 60 of about 126,114 (304)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Puromycin aminonucleoside modulates p130Cas of podocytes [PDF]
Korean Journal of Pediatrics, 2012 PurposePuromycin aminonucleoside (PAN) specifically injures podocytes, leading to foot process effacement, actin cytoskeleton disorganization, and abnormal distribution of slit diaphragm proteins. p130Cas is a docking protein connecting F-actin fibers to
Tae-Sun Ha +2 more
doaj +1 more source
GP-03 Synthesis and Antimicrobial Activity of Novel Puromycin Analogs
, 2023 Synthesis and Antimicrobial Activity of Novel Puromycin Analogs. Adrianna Cody,a Amy R. Messersmith,a Joshua V. Ruppel,b and Giuseppe Guminaa* aDepartment of Pharmaceutical and Administrative Sciences, Presbyterian College School of Pharmacy, 307 N ...
Cody, Adrianna L, Gumina, Giuseppe
core
BioTechniques, 2010 We have established an in vitro Cre/loxP-based assay for monitoring cell fusion events that specifically traces the transport of cytoplasm from one cell to its fusion partner.
Kurt Pfannkuche +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Murine transgenic iPS cell line for monitoring and selection of cardiomyocytes
Stem Cell Research, 2016 We report here a transgenic murine induced pluripotent stem cell (iPSC) line expressing puromycin N-acetyltransferase (PAC) and enhanced green fluorescent protein (EGFP) under the control of α-myosin heavy chain promoter.
Azra Fatima +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Peptidyl puromycin synthesis; effect of several antibiotics which act on 50 S ribosomal subunits
, 1971 The effects of several antibiotics which are know to bind with 50 S ribosomal subunits, on the formation of several di- and tri-peptidyl puromycins have been examined.
Mikio Tamaki +5 more
core +1 more source
Puromycin inhibition of cholesterol absorption in the rat
Journal of Lipid Research, 1977 The effect of puromycin on the intestinal absorption of cholesterol has been studied in rats with indwelling catheters in the left thoracic lymphatic duct.
G V Vahouny +4 more
doaj +1 more source