Results 71 to 80 of about 275,165 (298)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Evasion Differential Games in the Space of Square Summable Sequences

Games
In this article, we consider simple-motion pursuit–evasion differential games in the Hilbert space of square summable sequences. We show that when the players have the same dynamic capabilities, evasion is possible under some assumptions about the ...
Bekhzod Aminov, Marks Ruziboev
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Interception Domain Approach to Orbital Multi-Player “Encirclement-Capture” Games: Theoretical Foundations and Solutions

Aerospace
In recent years, with the development of micro-satellite clusters and large-scale satellite constellations, the likelihood of multiple spacecraft engaging in orbital pursuit–evasion games has increased.
Xingchen Li, Xiao Zhou, Xiaodong Yu, Guangyu Zhao, Yidan Liu   +4 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Pursuit-evasion using evolutionary algorithms in an immnersive three-dimensional environment

, 2002
In view of the biological prevalence of pursuit-evasion conies6 they provide a useful test-bed for research into novel bio-inspired computing and control systems.
Eaton, Malachy, M. McMillan, Tuohy, Michael, M. Eaton, MALACHY EATON (12349513), Michael Tuohy (12581479), M. Tuohy   +6 more
core   +1 more source

Randomized pursuit-evasion in a polygonal environment

IEEE Transactions on Robotics, 2005
This paper contains two main results. First, we revisit the well-known visibility-based pursuit-evasion problem, and show that in contrast to deterministic strategies, a single pursuer can locate an unpredictable evader in any simply connected polygonal environment, using a randomized strategy. The evader can be arbitrarily faster than the pursuer, and
Volkan Isler, Sampath Kannan, Sanjeev Khanna   +2 more
openaire   +3 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A Predictive Learning-Based Pursuit Strategy for the Multiple-to-One Orbital Pursuit–Evasion Game

Space: Science & Technology
The scarcity of space orbit resources has intensified the issue of orbital games between spacecraft. This paper presents a control strategy for the pursuing spacecraft in a multiple-to-one orbital pursuit–evasion game problem.
Peng Yan, Chengchao Bai, Mingjiang Ji, Hongxing Zheng, Ling Meng, Peng Wu, Lu Cao, Wei Pan, Xiaojun Ban   +8 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source