Results 51 to 60 of about 275,165 (298)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Aerospace, 2023 In order to improve the problem of overly relying on situational information, high computational power requirements, and weak adaptability of traditional maneuver methods used by hypersonic vehicles (HV), an intelligent maneuver strategy combining deep ...
Yunhe Guo +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Pursuit-evasion games: a tractable framework for antijamming games in aerial attacks
EURASIP Journal on Wireless Communications and Networking, 2017 We solve a communication problem between a UAV and a set of receivers, in the presence of a jamming UAV, using differential game theory tools. We propose a new approach in which this kind of games can be approximated as pursuit-evasion games. The problem
Juan Parras +4 more
doaj +1 more source
Hierarchical Maneuver Decision Method Based on PG-Option for UAV Pursuit-Evasion Game
Drones, 2023 Aiming at the autonomous decision-making problem in an Unmanned aerial vehicle (UAV) pursuit-evasion game, this paper proposes a hierarchical maneuver decision method based on the PG-option.
Bo Li +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Remote SensingFor the satellite orbit pursuit–evasion game problem, this paper proposes a multi-stage optimization-based solution aimed at improving the confrontation strategies between task satellites and target satellites in complex space environments.
Jian Wu +4 more
doaj +1 more source
Pursuit-Evasion in Models of Complex Networks [PDF]
Internet Mathematics, 2007 Pursuit-evasion games, such as the game of Cops and Robbers, are a simplified model for network security. In this game, cops try to capture a robber loose on the vertices of the network. The minimum number of cops required to win on a graph G is its number.
Anthony Bonato +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source