Results 1 to 10 of about 12,600 (98)

Pregnane X receptor protects against age-related bone loss in males via PI3K/Akt-mediated inhibition of apoptosis [PDF]

Cell Death Discovery
The pregnane X receptor (Pxr) regulates metabolism and inflammation, but its roles in bone homeostasis remain elusive. This study demonstrates that Pxr deficiency in bones induces osteoporotic phenotypes, with reduced trabecular bone mass, impaired ...
Shangzhi Li, Yu Xu, Wenpeng Xu, Dingxin Zhang, Xiangyu Lin, Peijie Hu, Haipeng Si   +6 more
doaj   +2 more sources

Targeting pregnane X receptor with a potent agonist-based PROTAC to delay colon cancer relapse [PDF]

Oncogenesis
Tumor recurrence is frequently attributed to drug-tolerant cancer cells. We previously demonstrated that downregulation of the Pregnane X Receptor (PXR, NR1I2) reduces chemoresistance and prevents colorectal cancer recurrence in xenograft mouse models ...
Lucile Bansard, Guillaume Laconde, Vanessa Delfosse, Tiphaine Huet, Margaux Ayeul, Emilie Rigal, Quentin Donati, Sabine Gerbal-Chaloin, Martine Daujat-Chavanieu, Luc Brunel, Baptiste Legrand, Alain Chavanieu, Anthony R. Martin, Julie Pannequin, William Bourguet, Muriel Amblard, Jean Marc Pascussi   +16 more
doaj   +2 more sources

Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice)

Liver Research, 2022
Background and aims: The herbal supplement Gancao, also known as licorice, belongs to the genus Glycyrrhiza and has been used worldwide for its hepatoprotective effect. Recent studies have raised concerns about potential herb-drug interactions associated
Anqi Cheng, Saifei Lei, Junjie Zhu, Jie Lu, Mary F. Paine, Wen Xie, Xiaochao Ma   +6 more
doaj   +1 more source

Bile acid dysmetabolism in inflammatory bowel diseases

Alʹmanah Kliničeskoj Mediciny, 2023
Aim: To summarize the state-of-the-art data on the molecular mechanisms of bile acid (BA) synthesis and absorption, their impaired absorption and receptor-dependent signaling, as well as on the effects of the gut microbiota on BA metabolism in ...
Daria A. Kuznetsova, Sergey V. Lapin, Irina V. Gubonina   +2 more
doaj   +1 more source

Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis

Cells, 2022
Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily that is activated by a variety of endogenous metabolites or xenobiotics. Its downstream target genes are involved in metabolism, inflammation and processes closely related to ...
Mengyao Qin, Yu Xin, Yong Bian, Xuan Yang, Tao Xi, Jing Xiong   +5 more
doaj   +1 more source

Panax notoginseng saponins increases the blood concentration of nifedipine by inhibiting CYP3A4 enzyme through PXR- and CAR-Mediated pathway

World Journal of Traditional Chinese Medicine, 2021
Objective: To explore the mechanism underlying the effect of Panax notoginseng saponins (PNS) on the pharmacokinetics of nifedipine (NF) in rats. Materials and Methods: Twenty-four rats were randomly divided into blank (BL) group, PNS group, NF group ...
Qiu-Hong Li, Jiao Zhao, Ai-Xia Ju, Yong Hu, Qing-Song Qie, Hong-Bin Xiao, Guang Xu, Xi-Jun Wang   +7 more
doaj   +1 more source

Molecular interactions of Andrographis paniculata Burm. f. Active Compound with Nuclear Receptor (CAR and PXR): An In Silico Assessment Approach

Indonesian Journal of Chemistry, 2022
The study aims to analyze the potential Herb-Drug Interactions (HDIs) of the chemical compound in Andrographis paniculate Burm. f. against Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR).
Elza Sundhani, Agung Endro Nugroho, Arief Nurrochmad, Endang Lukitaningsih   +3 more
doaj   +1 more source

Discrepancy in interactions and conformational dynamics of pregnane X receptor (PXR) bound to an agonist and a novel competitive antagonist

Computational and Structural Biotechnology Journal, 2022
Pregnane X receptor (PXR) is a nuclear receptor with an essential role in regulating drug metabolism genes. While the mechanism of action for ligand-mediated PXR agonism is well-examined, its ligand-mediated inhibition or antagonism is poorly understood.
Azam Rashidian, Enni-Kaisa Mustonen, Thales Kronenberger, Matthias Schwab, Oliver Burk, Stefan A. Laufer, Tatu Pantsar   +6 more
doaj   +1 more source

The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation

Acta Pharmaceutica Sinica B, 2023
Pregnane X receptor (PXR) is a ligand-activated nuclear receptor that transcriptionally upregulates drug-metabolizing enzymes [e.g., cytochrome P450 3A4 (CYP3A4)] and transporters.
Rebecca R. Florke Gee, Andrew D. Huber, Jing Wu, Richa Bajpai, Allister J. Loughran, Shondra M. Pruett-Miller, Taosheng Chen   +6 more
doaj   +1 more source

Nuclear Receptor PXR Confers Irradiation Resistance by Promoting DNA Damage Response Through Stabilization of ATF3

Frontiers in Oncology, 2022
Low response rate to radiotherapy remains a problem for liver and colorectal cancer patients due to inappropriate DNA damage response in tumors. Here, we report that pregnane X receptor (PXR) contributes to irradiation (IR) resistance by promoting ...
Xiaxia Niu, Hongmei Cui, Xinsheng Gu, Ting Wu, Min Sun, Changlong Zhou, Mei Ma   +6 more
doaj   +1 more source