Results 11 to 20 of about 12,669 (162)

Resveratrol as an Inhibitor of Pregnane X Receptor (PXR): Another Lesson in PXR Antagonism

Journal of Pharmacological Sciences, 2014
.: The pregnane X receptor (PXR) plays a central role in the regulation of metabolism. Only few PXR antagonists have been described and the mechanism of PXR inhibition is mostly hypothetical or believed to be allosteric.
Tomas Smutny, Petr Pavek
doaj   +4 more sources

The Furan Fatty Acids 11M5 and 11D5 Can Act as Activators of Human Peroxisome Proliferator-Activated Receptor Gamma. [PDF]

Mol Nutr Food Res
Furan fatty acids are abundant in food such as fatty fish. Here we show that some of these can bind to and act as activators of the nuclear receptors, peroxisome proliferator‐activated receptor gamma (PPAR‐gamma) and retinoid X receptor (RXR), in human cells.
Pospiech J, Caspi A, Vetter W, Kerem Z, Frank J, Kufer TA.   +5 more
europepmc   +2 more sources

Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia [PDF]

Cells, 2022
Atherosclerosis is a major global health concern. The central modifiable risk factors and causative agents of the disease are high total and low-density lipoprotein (LDL) cholesterol. To reduce morbidity and mortality, a thorough understanding of the factors that influence an individual’s cholesterol status during the decades when the arteria-narrowing
Mikko Karpale, Janne Hukkanen, Jukka Hakkola   +2 more
openaire   +4 more sources

Cytochrome P450 Regulation by α-Tocopherol in Pxr-Null and PXR-Humanized Mice [PDF]

Drug Metabolism and Disposition, 2013
The pregnane X receptor (PXR) has been postulated to play a role in the metabolism of α-tocopherol owing to the up-regulation of hepatic cytochrome P450 (P450) 3A in human cell lines and murine models after α-tocopherol treatment. However, in vivo studies confirming the role of PXR in α-tocopherol metabolism in humans presents significant difficulties ...
Caroline H, Johnson, Jessica A, Bonzo, Jie, Cheng, Kristopher W, Krausz, Dong Wook, Kang, Hans, Luecke, Jeffrey R, Idle, Frank J, Gonzalez   +7 more
openaire   +2 more sources

PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α

Cells, 2021
Background: PXR is a xenobiotic-responsive nuclear receptor that controls the expression of drug-metabolizing enzymes. Drug-induced activation of PXR sometimes causes drug–drug interactions due to the induced metabolism of co-administered drugs.
Ryota Shizu, Kanako Ezaki, Takumi Sato, Ayaka Sugawara, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari   +6 more
doaj   +1 more source

Marine Ligands of the Pregnane X Receptor (PXR): An Overview

Marine Drugs, 2019
Pregnane X Receptor (PXR) is a ligand-activated transcription factor which binds many structurally different molecules. The receptor is able to regulate the expression of a wide array of genes and is involved in cancer and different key physiological ...
Alejandro Carazo, Přemysl Mladěnka, Petr Pávek   +2 more
doaj   +1 more source

PXR and Metabolism

The FASEB Journal, 2021
Pregnane X receptor (PXR) is a nuclear receptor initially characterized as a xenobiotic‐sensing receptor that transcriptionally induces drug‐metabolizing enzymes and transporters to control the disposition of xenobiotics. Emerging data reveal PXR's broader roles in regulating glucose and lipid metabolism to control metabolic homeostasis.
openaire   +1 more source

Role of nuclear pregnane X receptor in Cu-induced lipid metabolism and xenobiotic responses in largemouth bass (Micropterus salmoides)

Frontiers in Endocrinology, 2022
The pregnane X receptor (PXR) is a master xenobiotic-sensing receptor in response to toxic byproducts, as well as a key regulator in intermediary lipid metabolism.
Hongyan Li, Wangbao Gong, Guangjun Wang, Ermeng Yu, Jingjing Tian, Yun Xia, Zhifei Li, Kai Zhang, Jun Xie   +8 more
doaj   +1 more source

Deficiency of PXR decreases atherosclerosis in apoE-deficient mice

Journal of Lipid Research, 2011
The pregnane X receptor (PXR, also known as SXR) is a nuclear hormone receptor activated by xenobiotics as well as diverse sterols and their metabolites.
Yipeng Sui, Jinxian Xu, Jennifer Rios-Pilier, Changcheng Zhou   +3 more
doaj   +1 more source

Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice[S]

Journal of Lipid Research, 2020
The pregnane X receptor (PXR) is a nuclear receptor that can be activated by numerous drugs and xenobiotic chemicals. PXR thereby functions as a xenobiotic sensor to coordinately regulate host responses to xenobiotics by transcriptionally regulating many
Yipeng Sui, Zhaojie Meng, Se-Hyung Park, Weiwei Lu, Christopher Livelo, Qi Chen, Tong Zhou, Changcheng Zhou   +7 more
doaj   +1 more source