Results 61 to 70 of about 12,669 (162)

Transcriptional regulation of mouse PXR gene: an interplay of transregulatory factors. [PDF]

PLoS ONE, 2012
Pregnane X Receptor (PXR) is an important ligand-activated nuclear receptor functioning as a 'master regulator' of expression of phase I, phase II drug metabolizing enzymes, and members of the drug transporters.
Sangeeta Kumari, Gauranga Mukhopadhyay, Rakesh K Tyagi   +2 more
doaj   +1 more source

Glucomannan from Dendrobium officinale Alleviates Colitis via Modulating Gut Microbiota and Upregulating Deoxycholic Acid Production

Food Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Dietary fiber is a bioactive substance that can modulate gut microbiota and exert a relieving effect on inflammatory bowel disease (IBD). Dendrobium officinale polysaccharide (DOP) is a type of bioactive dietary fiber that has been proven to have various biological activities on intestinal function.
Jie Xu, Shanshan Zhang, Qi Chen, Chenqing Xu, Siying Wu, Qiongni Lin, Zhipeng Li, Qixing Nie   +7 more
wiley   +1 more source

Inflammatory bowel disease and metabolic reprogramming: From pathological mechanisms to targeted interventions

Interdisciplinary Medicine, Volume 4, Issue 1, January 2026.
This review explores the role of metabolic reprogramming in inflammatory bowel disease (IBD) by focusing on immune and epithelial cell metabolism, microbial metabolites, and their impact on inflammation. It discusses emerging metabolic therapies and emphasizes the importance of personalized microbiota‐targeted approaches to improve clinical outcomes in
Zemin Tian, Yinde Huang, Ying Wang, Chenyu Zhao, Zhaokai Zhou, Hua Yang, Yuan Qiu   +6 more
wiley   +1 more source

Generation of a PXR reporter human induced pluripotent stem cell line (PXR-mCherry hiPSC) using the CRISPR/Cas9 system

Stem Cell Research, 2018
Pregnane X receptor (PXR) is a key nuclear receptor that mediates drug metabolism and stimulates hepatocyte proliferation. However, the lack of PXR expression in human pluripotent stem cell-derived hepatocytes limits their application for drug screening ...
Hyemin Kim, Ji-Woo Kim, So-Jin Kim, Young-Jun Choi, Dae-Sung Kim, Han-Jin Park   +5 more
doaj   +1 more source

Associations between Pregnane X Receptor and Breast Cancer Growth and Progression

Cells, 2020
Pregnane X receptor (PXR, NR1I2) is a member of the ligand-activated nuclear receptor superfamily. This receptor is promiscuous in its activation profile and is responsive to a broad array of both endobiotic and xenobiotic ligands.
Bradley A. Creamer, Shelly N. B. Sloan, Jennifer F. Dennis, Robert Rogers, Sidney Spencer, Andrew McCuen, Purnadeo Persaud, Jeff L. Staudinger   +7 more
doaj   +1 more source

Prevention of D-GalN/LPS-induced ALI by 18β-glycyrrhetinic acid through PXR-mediated inhibition of autophagy degradation

Cell Death and Disease, 2021
Acute liver injury (ALI) has multiple causes and results in liver dysfunction. Severe or persistent liver injury eventually leads to liver failure and even death.
Shouyan Wu, Henglei Lu, Wenjie Wang, Luyao Song, Meng Liu, Yuhan Cao, Xinming Qi, Jianhua Sun, Likun Gong   +8 more
doaj   +1 more source

Anti‐Tubercular Drug‐Induced Liver Injury: Current Understanding and Emerging Directions

JGH Open, Volume 10, Issue 1, January 2026.
ABSTRACT Most common adverse effect causing cessation of anti‐tubercular treatment (ATT) is drug‐induced liver injury (DILI) which is unpredictable due to its idiosyncratic nature. ATT is the most common cause of DILI and drug‐induced acute liver failure (ALF) in South East Asia.
Shubham Prasad, Himanshu Narang, Saurabh Kedia, Vineet Ahuja   +3 more
wiley   +1 more source

FBXO44 Regulates FOXP1 Degradation Through AURKA‐Dependent Phosphorylation to Promote Colorectal Cancer Progression

Advanced Science, Volume 12, Issue 47, December 18, 2025.
FBXO44 promotes colorectal cancer progression by targeting FOXP1 for ubiquitin‐mediated degradation. This study reveals a phosphorylation‐dependent mechanism involving AURKA and highlights the FBXO44/FOXP1/Cyclin E2 axis as a potential therapeutic target in colorectal cancer.
Hongxu Nie, Hengjie Xu, Sheng Yang, Chuanxin Tian, Tuo Wang, Chi Jin, Zhihao Chen, Xiaowei Wang, Junwei Tang, Yifei Feng, Yueming Sun   +10 more
wiley   +1 more source

Drug-activated nuclear receptors CAR and PXR

Annals of Medicine, 2003
The metabolism and elimination of drugs is mainly mediated by cytochrome P450 (CYP) enzymes, aided by conjugative enzymes and transport proteins. An integral aspect of this elimination process is the induction of drug metabolism through activation of gene expression of metabolic and transport proteins.
Paavo, Honkakoski, Tatsuya, Sueyoshi, Masahiko, Negishi   +2 more
openaire   +2 more sources

Activation of nuclear receptor pregnane-X-receptor protects against abdominal aortic aneurysm by inhibiting oxidative stress

Redox Biology
Abdominal aortic aneurysm (AAA) is a life-threatening condition, but effective medications to prevent its progression and rupture are currently lacking. The nuclear receptor pregnane-X-receptor (PXR) plays a crucial role in vascular homeostasis. However,
Zhi Shen, Jinxi Wang, Yifei Chen, Peiliang Fang, Ancai Yuan, Alex F. Chen, Xiaoxiang Yan, Yuyan Lyu, Jun Pu   +8 more
doaj   +1 more source