Results 11 to 20 of about 108,821 (298)
Optogenetic Stimulation of Prelimbic Pyramidal Neurons Maintains Fear Memories and Modulates Amygdala Pyramidal Neuron Transcriptome. [PDF]
Int J Mol Sci, 2021 Fear extinction requires coordinated neural activity within the amygdala and medial prefrontal cortex (mPFC). Any behavior has a transcriptomic signature that is modified by environmental experiences, and specific genes are involved in functional plasticity and synaptic wiring during fear extinction.
Laricchiuta D +15 more
europepmc +6 more sources
Inferring Pyramidal Neuron Morphology using EAP Data. [PDF]
Int IEEE EMBS Conf Neural Eng, 2023 We report a computational algorithm that uses an inverse modeling scheme to infer neuron position and morphology of cortical pyramidal neurons using spatio-temporal extracellular action potential recordings.. We first develop a generic pyramidal neuron model with stylized morphology and active channels that could mimic the realistic ...
Chen Z, Carroll M, Nair SS.
europepmc +3 more sources
General Anesthesia Decouples Cortical Pyramidal Neurons [PDF]
Cell, 2020 The mystery of general anesthesia is that it specifically suppresses consciousness by disrupting feedback signaling in the brain, even when feedforward signaling and basic neuronal function are left relatively unchanged. The mechanism for such selectiveness is unknown.
Mototaka, Suzuki, Matthew E, Larkum
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Dendritic Properties of Turtle Pyramidal Neurons [PDF]
Journal of Neurophysiology, 2008 The six-layered mammalian neocortex evolved from the three-layered paleocortex, which is retained in present-day reptiles such as the turtle. Thus the turtle offers an opportunity to examine which cellular and circuit properties are fundamental to cortical function.
Matthew E, Larkum +4 more
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Fractional differentiation by neocortical pyramidal neurons [PDF]
Nature Neuroscience, 2008 Neural systems adapt to changes in stimulus statistics. However, it is not known how stimuli with complex temporal dynamics drive the dynamics of adaptation and the resulting firing rate. For single neurons, it has often been assumed that adaptation has a single time scale.
Lundstrom, Brian Nils +3 more
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Cholinergic Inhibition of Neocortical Pyramidal Neurons [PDF]
The Journal of Neuroscience, 2005 Acetylcholine (ACh) is a central neurotransmitter critical for normal cognitive function. Here we show that transient muscarinic acetylcholine receptor activation directly inhibits neocortical layer 5 pyramidal neurons. Using whole-cell and cell-attached recordings from neurons in slices of rat somatosensory cortex, we demonstrate that transient ...
Gulledge, Allan T, Stuart, Gregory J
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Neurons as Canonical Correlation Analyzers
Frontiers in Computational Neuroscience, 2020 Normative models of neural computation offer simplified yet lucid mathematical descriptions of murky biological phenomena. Previously, online Principal Component Analysis (PCA) was used to model a network of single-compartment neurons accounting for ...
Cengiz Pehlevan +4 more
doaj +1 more source
Nrg1 Reverse Signaling in Cortical Pyramidal Neurons [PDF]
The Journal of Neuroscience, 2010 Peer ...
Peregrin, Sandra, Fazzari, Pietro
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Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model
Neurobiology of Disease, 2023 Tau protein pathology is a hallmark of many neurodegenerative diseases, including Alzheimer's Disease or frontotemporal dementia. Synaptic dysfunction and abnormal visual evoked potentials have been reported in murine models of tauopathy, but little is ...
Aleksandra Parka +9 more
doaj +1 more source
New insights into the classification and nomenclature of cortical GABAergic interneurons. [PDF]
, 2013 A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web ...
A Karagiannis +82 more
core +3 more sources