Results 31 to 40 of about 108,821 (298)
Pyramidal Neuron as Two-Layer Neural Network [PDF]
Neuron, 2003 The pyramidal neuron is the principal cell type in the mammalian forebrain, but its function remains poorly understood. Using a detailed compartmental model of a hippocampal CA1 pyramidal cell, we recorded responses to complex stimuli consisting of dozens of high-frequency activated synapses distributed throughout the apical dendrites.
Poirazi, Panayiota +2 more
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Frontiers in Synaptic Neuroscience, 2023 Synaptic plasticity is believed to be a key mechanism underlying learning and memory. We developed a phenomenological N-methyl-D-aspartate (NMDA) receptor-based voltage-dependent synaptic plasticity model for synaptic modifications at hippocampal CA3-CA1
Justinas J. Dainauskas +4 more
doaj +1 more source
Dedicated hippocampal inhibitory networks for locomotion and immobility [PDF]
, 2017 Network activity is strongly tied to animal movement; however, hippocampal circuits selectively engaged during locomotion or immobility remain poorly characterized.
Arriaga, Moises, Han, Edward B
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Frontiers in Neuroanatomy, 2011 The most ubiquitous neuron in the cerebral cortex, the pyramidal cell, is characterised by markedly different dendritic structure among different cortical areas. The complex pyramidal cell phenotype in granular prefrontal cortex (gPFC) of higher primates
Guy eElston +4 more
doaj +1 more source
High fidelity optogenetic control of individual prefrontal cortical pyramidal neurons in vivo [PDF]
, 2012 Precise spatial and temporal manipulation of neural activity in specific genetically defined cell populations is now possible with the advent of optogenetics.
Baratta, Michael V. +4 more
core +3 more sources
NPTX2 and cognitive dysfunction in Alzheimer’s Disease
eLife, 2017 Memory loss in Alzheimer’s disease (AD) is attributed to pervasive weakening and loss of synapses. Here, we present findings supporting a special role for excitatory synapses connecting pyramidal neurons of the hippocampus and cortex with fast-spiking ...
Mei-Fang Xiao +19 more
doaj +1 more source
A perspective on cortical layering and layer-spanning neuronal elements [PDF]
, 2018 This review article addresses the function of the layers of the cerebral cortex. We develop the perspective that cortical layering needs to be understood in terms of its functional anatomy, i.e., the terminations of synaptic inputs on distinct cellular ...
Larkum, Matthew E. +3 more
core +2 more sources
The “psychiatric” neuron: the psychic neuron of the cerebral cortex, revisited
Frontiers in Human NeuroscienceNearly 25 years ago, Dr. Patricia Goldman-Rakic published her review paper, “The ‘Psychic’ Neuron of the Cerebral Cortex,” outlining the circuit-level dynamics, neurotransmitter systems, and behavioral correlates of pyramidal neurons in the cerebral ...
L. Taylor Flynn +5 more
doaj +1 more source
Frontiers in Neuroscience, 2009 Studies of pathological ion channel regulation as an underlying mechanism of epilepsy have revealed alterations of the h-current in several animal models.
Jonas Dyhrfjeld-Johnsen +3 more
doaj +1 more source
Long distance projections of cortical pyramidal neurons [PDF]
Journal of Neuroscience Research, 2016 The neuronal circuits defined by the axonal projections of pyramidal neurons in the cerebral cortex are responsible for processing sensory and other information to plan and execute behavior. Subtypes of cortical pyramidal neurons are organized across layers, with those in different layers distinguished by their patterns of axonal projections and ...
Gerfen, Charles R. +2 more
openaire +3 more sources