Results 71 to 80 of about 13,234 (272)

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

Simultaneous Determination of 20 Pyrazines in Baijiu by Gas Chromatography-Tandem Mass Spectrometry [PDF]

Shipin Kexue
In this study, a method for the simultaneous determination of 20 pyrazines in baijiu was established by direct injection (DI) combined with gas chromatography-tandem mass spectrometry (GC-MS/MS), and the pyrazines in 10 brands of baijiu with different ...
WANG Na, SHEN Yi, ZHUANG Yuan, CHENG Wei, LUO Sen, ZHANG Yadong, LIU Zixuan, LIU Bing, GAO Hongbo
doaj   +1 more source

Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides. [PDF]

, 2017
A palladium-catalyzed difluoromethylation of a series of heteroaryl chlorides, bromides and iodides under mild conditions is described. A wide range of heteroaryl halides such as pyridyl, pyrimidyl, pyrazyl, funanyl, thienyl, pyazolyl, imidazolyl ...
Gu, Yang, Gu, Yucheng, Lu, Changhui, Shen, Qilong, Wu, Jiang   +4 more
core   +1 more source

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

Pyrazine: Supercollisions or simple reactions? [PDF]

The Journal of Chemical Physics, 1995
Photodissociation of 1,4 diazine (pyrazine) following 248 nm (S2←S0) and 308 nm (S1←S0) excitation has been studied by photofragment translational spectroscopy. While the latter wavelength was inefficient at generating reactive products, the former wavelength afforded a rich variety of fragments, the most translationally energetic being HCN carrying up
CHESKO J. D., STRANGES, Domenico, SUITS A. G., LEE Y. T.   +3 more
openaire   +1 more source

Atroposelective Access to π‐Conjugated 1,2‐Azaborepines Enabled by Palladium‐Catalyzed Cyclization of N‐Heterobiaryls with Alkynylboronates

Advanced Science, EarlyView.
We report a palladium‐catalyzed atroposelective cyclization of N‐heterobiaryl triflates with alkynyl boronates to access seven‐membered 1,2‐BN‐bridged biaryls with high yields and excellent enantioselectivity via a cascade DyKAT, cis‐carbopalladation, and 1,2‐migration, which expands the toolbox for axially chiral π‐conjugated boron compounds and opens
Fengya He, Zhen Wang, Haoyu Guo, Shuguang Chen, Xu Zhang, Yongjia Shang, Hui Wang   +6 more
wiley   +1 more source

A Combined Experimental and Theoretical Study of the Ammonium Bifluoride Catalyzed Regioselective Synthesis of Quinoxalines and Pyrido[2,3-b]pyrazines

, 2015
International audienceAmmonium bifluoride was efficiently used (at a 0.5 mol % loading) to catalyze the cyclocondensation between 1,2-arylenediamines and 1,2-dicarbonyl compounds at room temperature in methanol-water, affording quinoxalines and pyrido[2 ...
Chevallier, Floris, Domingo, Luis R, Dorcet, Vincent, Lassagne, Frédéric, Mongin, Florence, Roisnel, Thierry   +5 more
core   +3 more sources

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Optimizing headspace temperature and time sampling for identification of volatile compounds in ground roasted Arabica coffee [PDF]

, 2001
Equilibration time and temperature were the factors studied to choose the best conditions for analyzing volatiles in roasted ground Arabica coffee by a static headspace sampling extraction method. Three temperatures of equilibration were studied: 60, 80,
Ansorena-Artieda, D. (Diana), Bello, J. (José), Cid, C. (Concepción), Sanz, C. (Cristina)   +3 more
core  

Alternative Translation Initiation in PRKN Delays the Onset of Parkinson's Disease and Offers a Therapeutic Target

Annals of Neurology, EarlyView.
Objective Biallelic variants in PRKN cause autosomal recessive Parkinson's disease (PD) with a median age at onset of 31 years. When evaluating the 16 previously published carriers of a homozygous deletion of Exon 2 from the International Parkinson's Disease and Movement Disorder Society Gene Database (MDSGene) database, the median age at onset is ...
Arian Hach, Katja Lohmann, Manabu Funayama, Poornima J. Menon, Eva‐Juliane Vollstedt, Teresa Kleinz, Hiroyo Yoshino, Suzanne Lesage, Britta Meier, Carolyn M. Sue, Jean‐Christophe Corvol, Alexis Brice, Nobutaka Hattori, Christine Klein, Aleksandar Rakovic   +14 more
wiley   +1 more source