Results 31 to 40 of about 7,109 (211)

Synthesis and oxidation of some azole-containing thioethers

Beilstein Journal of Organic Chemistry, 2011
Pyrazole and benzotriazole-containing thioethers, namely 1,5-bis(3,5-dimethylpyrazol-1-yl)-3-thiapentane, 1,8-bis(3,5-dimethylpyrazol-1-yl)-3,6-dithiaoctane and 1,3-bis(1,2,3-benzotriazol-1-yl)-2-thiapropane were prepared and fully characterized ...
Andrei S. Potapov, Nina P. Chernova, Vladimir D. Ogorodnikov, Tatiana V. Petrenko, Andrei I. Khlebnikov   +4 more
doaj   +1 more source

Cytotoxicity study of pyrazole derivatives

Bangladesh Journal of Pharmacology, 2008
El compuesto heterocíclico de pirazolona, 3-metil-1-fenil-2-pirazolina-5-ona 2(a) se sintetizó mediante reacción de condensación entre acetoacetato de etilo y fenilhidrazina y se convirtió en sus derivados heterocíclicos correspondientes 2(b) a 2(f2) .
Nusrat Binta Ahasan, Rabiul Islam
openaire   +3 more sources

Photochromic Cholesteric Liquid Crystals via Arylazopyrazole Functionalization of Hydroxypropyl Cellulose

Advanced Materials, EarlyView.
We produce a new derivative of hydroxypropyl cellulose functionalized with arylazopyrazole side chains and demonstrate its photoswitchable behaviors in dilute and concentrated aqueous solutions, ultimately designing a series of photochromic cholesteric materials that can be photopatterned as write‐erase displays.
Simona G. Fine, Nina Hildenhagen, Walter R. Linke, Michael Ryan Hansen, Bart Jan Ravoo, Cécile A. C. Chazot   +5 more
wiley   +1 more source

Synthesis of a 2-Furylpyrazoline Derivative Using Microwave Irradiation

Molbank, 2009
A simple method for the synthesis of pyrazoline derivative containing furan moiety was developed. Thus, 5-(6-bromo-1,3-benzodioxol-5-yl)-3-(2-furyl)-1-(3-methyl-phenyl)-4,5-dihydro-1H-pyrazole was synthesized using microwave irradiation and it was ...
Suban Syed Shafi, Balapragalathan Thappali Jothikrishnan   +1 more
doaj   +1 more source

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

3-Ethyl-4-methyl-1H-pyrazol-2-ium-5-olate

Acta Crystallographica Section E, 2011
The title compound, C6H10N2O, is a zwitterionic pyrazole derivative. The crystal packing is predominantly governed by a three-center iminium–amine N+—H...O−...H—N interaction, leading to an undulating sheet-like ...
R. S. Rathore, T. Narasimhamurthy, R. Venkat Ragavan, V. Vijayakumar, S. Sarveswari   +4 more
doaj   +1 more source

Evaluation of 3,5-Diphenyl-2-Pyrazolines for Antimitotic Activity by Inhibition of Tubulin Polymerization

Journal of Chemistry, 2022
Chalcones have a skeleton of diphenyls connected via an α,β-unsaturated carbonyl group. Many chalcone derivatives have been shown to interact with tubulin. Based on previous reports, chalcones derived by substitution of a carbonyl group with 2-pyrazoline
Soon Young Shin, Euitaek Jung, Young Han Lee, Yoongho Lim, Seunghyun Ahn, Dongsoo Koh   +5 more
doaj   +1 more source

Efficient synthesis, reactions and spectral characterization of pyrazolo[4’,3’:4,5]thieno[3,2-d] pyrimidines and related heterocycles

Heterocyclic Communications, 2019
New pyrazolothienopyrimidines were synthesized. The key intermediate 4-aminothieno[2,3-c]pyrazole-5-carbonitrile 1 was converted to the chloroacetyl amino derivative 2 followed by nucleophilic substitution and Dimorth rearrangement upon treatment with ...
Zaki Remon M., Kamal El-Dean Adel M., Radwan Shaban M., Saber Ahmed F.   +3 more
doaj   +1 more source

The biological activity of new thieno[2,3-c]pyrazole compounds as anti-oxidants against toxicity of 4-nonylphenol in Clarias gariepinus

Toxicology Reports, 2015
Synthesis of bi functionally substituted thieno[2,3-c]pyrazole compounds was carried out by a new method. The substituted group at position five is namely (carbonitrile, carboxamide, N-(substitutedphenyl) carboxamide and benzoyl group). Chloroacetylation
Alaa El-Din H. Sayed, Remon M. Zaki, Adel M. Kamal El-Dean, Abdullah Y. Abdulrazzaq   +3 more
doaj   +1 more source

Study of physiochemical properties of trisubstituted pyrazole derivatives using polar aprotic solvents

Scientific Reports
Pyrazole derivatives are aromatic heterocyclic compounds endowed with multifaceted applications. In the present study 1,3,4-trisubstituted pyrazoles derivatives have been synthesized for the purpose of studying their physical properties and their ...
Poonam Devi, Hardeep Anand, Rashmi Pundeer, Suresh Kumar   +3 more
doaj   +1 more source