Results 51 to 60 of about 7,109 (211)

The Newly Synthesized Pyrazole Derivative 5-(1-(3 Fluorophenyl)-1H-Pyrazol-4-yl)-2H-Tetrazole Reduces Blood Pressure of Spontaneously Hypertensive Rats via NO/cGMO Pathway

Frontiers in Physiology, 2018
The search for new antihypertensive drugs has grown in recent years because of high rate of morbidity among hypertensive patients and several side effects that are associated with the first-line medications.
Neidiane R. Trindade, Paulo R. Lopes, Lara M. Naves, James O. Fajemiroye, Pedro H. Alves, Nathalia O. Amaral, Luciano M. Lião, Ana C. S. Rebelo, Carlos H. Castro, Valdir A. Braga, Ricardo Menegatti, Gustavo R. Pedrino   +11 more
doaj   +1 more source

Synthesis, DFT, Molecular docking Analysis and Antibacterial, Antioxidant Activities of tri-substituted pyrazoles

ASM Science Journal, 2021
Pyrazole and its derivatives are contemplated crucial compounds in heterocyclic chemistry which are also used extensively in organic synthesis. These cycles are known for their biological and pharmacological activities.
Golea Lynda
doaj   +1 more source

Structural and Biological Insights Into Copper(I) Phosphane Complexes With Boron‐Phenylated Poly(3‐(CF3)Pyrazolyl)‐ and Poly(6‐(CF3)‐2‐pyridyl)‐Borates

Chemistry – A European Journal, EarlyView.
This study reports six new copper(I) complexes with unusual coordination and strong anticancer activity against a panel of human cancer cell lines derived from different solid tumors. The most active compounds outperform cisplatin, even in resistant cells, by inhibiting protein disulfide isomerase and inducing redox stress that triggers non‐apoptotic ...
Vo Quang Huy Phan, Jo’ Del Gobbo, Mukundam Vanga, Deepika V. Karade, Cristina Marzano, Valentina Gandin, Laura Rigon, Carlo Santini, Maura Pellei, H. V. Rasika Dias   +9 more
wiley   +1 more source

Two tautomers in the same crystal: 3-(4-fluorophenyl)-1H-pyrazole and 5-(4-fluorophenyl)-1H-pyrazole

Acta Crystallographica Section E, 2014
The title co-crystal, 3-(4-fluorophenyl)-1H-pyrazole–5-(4-fluorophenyl)-1H-pyrazole (1/1), C9H7FN2, crystallizes with four independent molecules (A, B, C and D) in the asymmetric unit exhibiting two tautomeric forms (A and D; B and C) due to N—H proton ...
Thammarse S. Yamuna, Manpreet Kaur, Jerry P. Jasinski, Brian J. Anderson, H. S. Yathirajan   +4 more
doaj   +1 more source

Sustainable Hydrogen Production by Glycerol and Monosaccharides Catalytic Acceptorless Dehydrogenation (AD) in Homogeneous Phase

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
Sustainable hydrogen production can be obtained from hydogen‐rich biomass‐derived organic molecules through Acceptorless Dehydrogenation (AD) reactions. Glycerol and sugars are available in large quantities from industry and can be successfully used as substrates in AD protocols, in the presence of tailored, selective, easily tunable and thermally ...
Sylwia Kostera, Luca Gonsalvi
wiley   +1 more source

Desulfurization of Benzothiophene Derivatives by Solvent Extraction Coupled With Oxidation Using Oxomolybdenum(VI) Bis(pyrazolyl)methane Catalysts

European Journal of Inorganic Chemistry, EarlyView.
A polymeric hybrid material formulated as [MoO3(bis(pyrazolyl)methane)] has been prepared and used as a catalyst precursor for the complete oxidative desulfurization of a model diesel containing recalcitrant benzothiophene derivatives. The precursor is converted in situ to an oxodiperoxo active species which is retained in the recyclable extractant ...
Ana C. Gomes, Fátima Mirante, Isabel S. Gonçalves, Martyn Pillinger, Salete S. Balula   +4 more
wiley   +1 more source

Correlation Between the Molecular Structure of Metal‐Supporting Ligands and Catalysis in the Oxygenase‐Mimicking Immobilized Metal Complex Catalysts

European Journal of Inorganic Chemistry, EarlyView.
The correlation between the structures of metal complexes immobilized in the mesopores of hydrophobically modified silicate supports was examined in relation to the catalytic activities toward C‐H oxidation. On the alkene oxidation with H2O2, the iron catalyst bearing bis(imidazolyl)methane ligand promotes allylic oxidation, whereas the mononuclear ...
Yuta Akizawa, Hiroe Fukuzaki, Nana Aizawa, Sho Ikeda, Airi Kawabe, Saori Nishiyama, Iori Nagasawa, Masaya Okamura, Shiro Hikichi   +8 more
wiley   +1 more source

Enzymatic Transglycosylation Features in Synthesis of 8-Aza-7-Deazapurine Fleximer Nucleosides by Recombinant E. coli PNP: Synthesis and Structure Determination of Minor Products

Biomolecules
Enzymatic transglycosylation of the fleximer base 4-(4-aminopyridine-3-yl)-1H-pyrazole using recombinant E. coli purine nucleoside phosphorylase (PNP) resulted in the formation of “non-typical” minor products of the reaction.
Barbara Z. Eletskaya, Anton F. Mironov, Ilya V. Fateev, Maria Ya. Berzina, Konstantin V. Antonov, Olga S. Smirnova, Alexandra B. Zatsepina, Alexandra O. Arnautova, Yulia A. Abramchik, Alexander S. Paramonov, Alexey L. Kayushin, Anastasia L. Khandazhinskaya, Elena S. Matyugina, Sergey N. Kochetkov, Anatoly I. Miroshnikov, Igor A. Mikhailopulo, Roman S. Esipov, Irina D. Konstantinova   +17 more
doaj   +1 more source

New Potent 5α- Reductase and Aromatase Inhibitors Derived from 1,2,3-Triazole Derivative

Molecules, 2020
This work describes the utility of pyrazole-4-carbaldehyde 1 as starting material for the synthesis of a novel potent series of 5α-reductase and aromatase inhibitors derived from 1,2,3-triazole derivative. Condensation of 1 with active methylene and
Mohamed El-Naggar, Amira S. Abd El-All, Shweekar I. A. El-Naem, Mohamed M. Abdalla, Huda R. M. Rashdan   +4 more
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Phosphorescent Platinum(II) Complexes With Diazinedipyrrolide Pincer Ligands: Structure and Photophysical Properties

European Journal of Inorganic Chemistry, EarlyView.
A new family of phosphorescent Pt(II) complexes with pyrimidinedipyrrolide ligands, including a pyrazine analog, was designed and synthesized. Their emission properties can be finely tuned via ligand modification, revealing strong phosphorescence originating from intraligand charge transfer transitions.
Marcela Horáková, Alexandre Rico, Filip Bureš, Pascal le Poul, Sébastien Gauthier, Jiří Váňa, Zdeňka Růžičková, Sylvain Achelle   +7 more
wiley   +1 more source