Results 111 to 120 of about 38,574 (278)

Organometallic complexes as anion hosts [PDF]

, 2008
Pérez Martínez, Julio Antonio, Riera Menéndez, Lucía   +1 more
core   +1 more source

Unveiling Benzoxazole‐Substituted Thiazolyl‐Pyrazole Derivatives Inducing Apoptosis by Targeting β‐Tubulin and Caspase‐3

ChemMedChem, EarlyView.
BP(1‐6) compounds designed from Benzoxazole and Thiazolyl‐Pyrazole scaffolds exhibited potent antitubulin and caspase‐3 activity in MDA‐MB‐231 cells. BP‐6 notably triggered apoptosis and disrupted cell proliferation. Docking studies validated strong binding affinities of BP‐2 and BP‐6 toward β‐tubulin and caspase‐3, suggesting promising therapeutic ...
Burak Kuzu, Mustafa Cakir, Eda Acikgoz, Mehmet Abdullah Alagoz   +3 more
wiley   +1 more source

Some Substituted 1H,4H- and 1H,5H-Pyrazolo[4,3-c]pyrazoles. Syntheses and Properties [PDF]

, 1974
Joung Hee Lee, Akira Matsumoto, Masayuki Yoshida, Osamu Simamura   +3 more
openalex   +1 more source

Human Liver Alcohol Dehydrogenase: Inhibition by Pyrazole and Pyrazole Analogs. [PDF]

Acta Chemica Scandinavica, 1969
Ting-Kai Li, Hugo Theorell, Charles Larsen, Per Halfdan Nielsen, Alf A. Lindberg, Gert Jansen, Bo Lamm, Benny Samuelsson   +7 more
openaire   +3 more sources

Development of Novel Anticancer Pyrazolopyrimidinones Targeting Glioblastoma

ChemMedChem, EarlyView.
Pyrazolo[1,5‐α]pyrimidinone derivatives exhibit selective cytotoxicity towards glioblastoma (GBM) cells over noncancerous cells. Structure–activity relationship studies identifies a lead compound with significant cytotoxicity activity, inducing apoptosis and necrosis in GBM cells, without affecting noncancerous cells. This demonstrates the potential of
Kate Byrne, Natalia Bednarz, Ciara McEvoy, John C. Stephens, James F. Curtin, Gemma K. Kinsella   +5 more
wiley   +1 more source

Studies on Fungicides. VII. Synthesis and Antifungal Activity of Some Pyrazole Derivatives.

, 1964
Jiro Kinugawa, Michihiko Ochiai, Chikashi Matsumura, Hiroichi Yamamoto   +3 more
openalex   +2 more sources

Impact of C18 Epimerization of Indole‐ and Pyrazole‐Fused 18β‐Glycyrrhetinic Acid Derivatives on PTP1B and TCPTP Inhibitory Activity: Synthesis, In Vitro, and In Silico Studies

ChemMedChem, EarlyView.
The indole derivative (FC‐114) and the N‐phenylpyrazole (FC‐122) of glycyrrhetinic acid are both potent inhibitors of the Protein Tyrosine Phosphatase 1B, with IC50 values of 0.48 μM and 1.15 μM, respectively. However, their activity decreases by up to four times when the 18β‐H position is epimerized to 18α‐H or when the carbonyl group at the C11 ...
Ledy De‐la‐Cruz‐Martínez, Rosendo Martínez‐Arellano, Mitzi López‐Sánchez, José G. Alvarado‐Rodríguez, Jesús Martin Torres‐Valencia, David Equihua‐González, Julio‐César Almanza‐Pérez, Jaime Pérez‐Villanueva, Martín González‐Andrade, José C. Páez‐Franco, Francisco Cortés‐Benítez   +10 more
wiley   +1 more source

Fluxional Behavior of Palladium(II) and Platinum(II) Complexes Containing both a Metal–Aryl Bond and a Pyrazole-derived Ligand [PDF]

, 1978
Masayoshi Onishi, Koji Sugimura, Katsuma Hiraki   +2 more
openalex   +1 more source

Molecular Docking and Target‐Specific Binding Profiles of Benzosuberane‐Based Compounds

ChemMedChem, EarlyView.
Benzosuberane represents a promising scaffold in medicinal chemistry. Several benzosuberane‐based derivatives are described in this review as anticancer agents, including antivascular agents, DNA‐intercalators, receptor modulators and kinase inhibitors.
Michail A. Saragatsis, Gemma K. Kinsella, James F. Curtin, Tao Zhang   +3 more
wiley   +1 more source

Syntheses of Pyrazole Derivatives. III

, 1963
Akira Takamizawa, Sadao Hayashi
openalex   +2 more sources