Vinylogous functionalization of 4-alkylidene-5-aminopyrazoles with methyl trifluoropyruvates
Beilstein Journal of Organic ChemistryA valuable vinylogous addition reaction between 4-alkylidene-5-aminopyrazoles and alkyl trifluoropyruvates leading to highly functionalized tertiary alcohols bearing a trifluoromethyl group and a pyrazole ring is presented.
Judit Hostalet-Romero +5 more
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Sex Differences in Asthma Pathogenesis
Immunological Reviews, Volume 337, Issue 1, January 2026.ABSTRACT There is a sex difference in asthma prevalence and asthma‐related morbidity that changes from childhood into different reproductive stages of life. The impact of sex hormone signaling on asthma pathogenesis has been partially elucidated using large cohort human studies, human cells, and animal models. Androgens decreased airway inflammation by
Kaitlin E. McKernan +2 more
wiley +1 more source
Pharmacological and Insect Antifeedant Activities of some 3-(2,4-Dichloro-5-Fluorophenyl)-5-(Substituted Phenyl)-4,5-Dihydro-1H-Pyrazole-1-Carbothioamides [PDF]
, 2014 Ganesamoorthy Thirunarayanan
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New 1,2,3-Triazole-Appended Bis-pyrazoles: Synthesis, Bioevaluation, and Molecular Docking
, 2021 Ashruba B. Danne +4 more
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Synthesis of a Novel Pyrano[2,3-C]pyrazole Enabling PKBβ/AKT2 Inhibitory and in Vitro Anti-Glioma Activity [PDF]
, 2021 Ruturajsinh M. Vala +6 more
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Catalytic Strategies for Amide‐Based Michael Additions: Advances and Perspectives
Journal of Chemistry, Volume 2026, Issue 1, 2026.The Michael addition is a cornerstone transformation in organic synthesis, enabling efficient C–C and C–heteroatom bond formation. Traditionally, α,β‐unsaturated carbonyl compounds such as enones and esters have dominated as Michael acceptors, whereas α,β‐unsaturated amides remain underutilized due to their strong resonance stabilization and low ...
Muhammad Naufal +6 more
wiley +1 more source
Synthesis and antimicrobial/antioxidant evaluation of novel pyrimidine-based derivatives with pendant pyrazoles using vinamidinum salts [PDF]
, 2023 Roya Maghamifar +4 more
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Transfer Hydrogenation: Advances in Manganese and Nickel Metal Catalysis
Journal of Chemistry, Volume 2026, Issue 1, 2026.Transfer hydrogenation (TH) of ketones, catalyzed by transition–metal complexes, produces alcohols, which are important building blocks in the pharmaceutical and fine chemical industries. For a long time, catalysts based on noble metals such as ruthenium, rhodium, and iridium have dominated the TH of ketones.
James Kamau +3 more
wiley +1 more source