Results 61 to 70 of about 27,892 (233)

Engineering on-surface spin crossover: spin-state switching in a self-assembled film of vacuum sublimable functional molecule [PDF]

arXiv, 2018
Realization of spin crossover (SCO) based applications requires studying of spin state switching characteristics of SCO complex molecules at nanostructured environments especially on-surface. Except for a very few cases, the SCO of a surface bound thin molecular film is either quenched or heavily altered due to (i) strong molecule-surface interactions ...
arxiv  

An Update: Enzymatic Synthesis for Industrial Applications

Angewandte Chemie International Edition, Accepted Article.
Supported by rapid technological advancements, biocatalytic applications have matured into a sustainable, scalable, and cost‐competitive alternatives to established chemical catalysis. This review presents the most recent examples of enzyme‐based solutions for the manufacturing of molecules with extended carbon‐carbon frameworks and multiple ...
Thomas Bayer, Shuke Wu, Radka Snajdrova, Kai Baldenius, Uwe Bornscheuer   +4 more
wiley   +1 more source

Characterization of the pattern of development of key compounds contributing to aroma quality of chicken meat and their metabolic markers

Animal Research and One Health, EarlyView.
The graphical abstract shows the principal results of this study. Eight major aroma‐contributing compounds (nonanal, octanal, dimethyl tetrasulfide, hexanal, 1‐octen‐3‐ol, (E)‐2‐nonenal, heptanal, and (E,E)‐2,4‐decadienal) were identified by electronic nose and GC‐O‐MS analysis, and their content increased with age.
Yanke Wang, Xiaojing Liu, Yongli Wang, Zhengxiao He, Guiping Zhao, Jie Wen, Huanxian Cui   +6 more
wiley   +1 more source

Catalysis in Chemical Modification of Proteins

ChemCatChem, EarlyView.
Catalytic principles of synthetic organic chemistry have been increasingly applied to chemical modification of proteins during the recent years. This review article describes how seven types of catalytic systems —electrocatalysis, photocatalysis, metal catalysis, acid catalysis, organocatalysis, supramolecular catalysis, and heterogeneous catalysis ...
Seiya Ishizawa, Koki Fujimura, Kounosuke Oisaki, Shinichi Sato, Jun Ohata   +4 more
wiley   +1 more source

Design and Evaluation of Bivalent K‐Ras Inhibitors That Target the CAAX Binding Site and the Acidic Surface of Farnesyltransferase and Geranylgeranyltransferase I

Chemistry – A European Journal, EarlyView.
Chemical inhibition of K‐Ras posttranslational prenylation represents a promising strategy against aggressive cancers. A structure‐based design produces piperidine‐based peptidomimetics conjugated to cationic modules, effectively inhibiting FTase and GGTase I at single‐digit nanomolar concentrations.
Naomi Horiuchi, Rania Omer, Fumitoshi Sugino, Naomi Ogino, Yoshihisa Inoue, Kazi Aslamuzzaman, Takeyuki Suzuki, Said M. Sebti, Junko Ohkanda   +8 more
wiley   +1 more source

C2‐linked alkynyl poly‐ethylene glycol(PEG) adenosine conjugates as water‐soluble adenosine receptor agonists

Chemical Biology &Drug Design, Volume 101, Issue 2, Page 340-349, February 2023., 2023
Non‐cytotoxic C2‐linked alkynyl oligo ethylene glycol adenosine conjugates are highly water soluble and stimulate adenosine receptor activity. Abstract A series of 12 novel polyethylene‐glycol(PEG)‐alkynyl C2‐adenosine(ADN) conjugates were synthesized using a robust Sonogashira coupling protocol and characterized by NMR spectroscopy and mass ...
Lindsay Ferguson, Nasrin Shokrzadeh Madieh, Alexandra Vaideanu, Andreas Schatzlein, Joseph Festa, Harprit Singh, Geoffrey Wells, Sanjib Bhakta, Federico Brucoli   +8 more
wiley   +1 more source

Preassembly‐Controlled Radical Recombination at Bismuth: Decarboxylative C─N Coupling with Sulfonamides

Chemistry – A European Journal, EarlyView.
Radical processes involving bismuth hold great potential, but innovative strategies are required to control the reactivity of bismuth intermediates. Herein, we report a direct photochemical decarboxylation with molecular bismuth for C─N coupling of benzylic carboxylic acids and sulfonamides.
Elina K. Taskinen, Dominik Birnthaler, Vid Kermelj, Burkhard König   +3 more
wiley   +1 more source

Fused Nitrogen Bridgehead N,O‐Acetals as Versatile Scaffolds: Synthetic Strategies, Mechanism and Applications

Chemistry – A European Journal, EarlyView.
Fused nitrogen‐bridgehead N,O‐acetals receive specific emphasis as pivotal scaffolds due to their significant role in the bioactivity of medicinally relevant molecules. Significant approaches have been reported on their role as key synthetic building blocks/motifs in the construction of complex organic molecules and their utility as chiral auxiliaries ...
Alexis D. Kouvelas, Michael G. Kallitsakis, Ioannis N. Lykakis   +2 more
wiley   +1 more source

Endohedral Coordination of Bulky Substrates in Metalloenzyme‐Like Organometallic Nanotubes

Chemistry – A European Journal, EarlyView.
An organometallic nanotube with eight CuI ions mimics metalloenzyme behavior, featuring a flexible pore, metal‐ligand substrate binding, and redox‐active metals. Insertion of THF as a model substrate is driven by coordination, as confirmed by SC‐XRD, NMR, and DFT.
Thomas Pickl, Patrick Mollik, Markus R. Anneser, Florian Sixt, Korbinian Geißer, Oksana Storcheva, Dominik P. Halter, Alexander Pöthig   +7 more
wiley   +1 more source

The red blood cell as a mediator of endothelial dysfunction in patients with familial hypercholesterolemia and dyslipidemia

Journal of Internal Medicine, Volume 293, Issue 2, Page 228-245, February 2023., 2023
Abstract Background Patients with familial hypercholesterolemia (FH) display high levels of low‐density lipoprotein cholesterol (LDL‐c), endothelial dysfunction, and increased risk of premature atherosclerosis. We have previously shown that red blood cells (RBCs) from patients with type 2 diabetes induce endothelial dysfunction through increased ...
Ali Mahdi, Tigist Wodaje, Oskar Kövamees, John Tengbom, Allan Zhao, Tong Jiao, Marcus Henricsson, Jiangning Yang, Zhichao Zhou, Anni I. Nieminen, Malin Levin, Aida Collado, Jonas Brinck, John Pernow   +13 more
wiley   +1 more source