Results 61 to 70 of about 38,574 (278)

Dual‐Ligand Strategy in Rh‐Catalyzed Sequential Hydrofunctionalization of Valylene

Advanced Science, EarlyView.
A remarkable dual‐ligand strategy is employed in Rh‐catalyzed sequential coupling reaction of dinucleophiles and 1,3‐enynes with high regio‐ and chemo‐selectivity. Abstract Controlling regio‐ and chemo‐selectivity in transition‐metal‐catalyzed reactions involving coupling reagents with multiple reactive sites remains a significant challenge.
Yong‐Kang Mei, Su‐Yang Xu, Zhi‐Hui Wang, Ding‐Wei Ji, Qing‐An Chen   +4 more
wiley   +1 more source

Potent Fluorescent Probe for Target‐Engagement Studies of Allosteric Pyruvate Kinase Modulators

Angewandte Chemie, EarlyView.
LumiPK, a novel environment‐sensitive fluorescent tracer, enables direct monitoring of allosteric ligand engagement with pyruvate kinase fused with nanoluciferase (Nluc), focusing on the liver isoform (PKL). In NanoBRET, and fluorescence indicator displacement assays, LumiPK shows high affinity and validates known allosteric modulators of PKL.
Oscar Nilsson, Anna P. Valaka, Liliana Håversen, Agnieszka Bogucka, István Köteles, Paul Brear, Mikael Rutberg, Anders Gunnarsson, Marko Hyvönen, Morten Grøtli   +9 more
wiley   +2 more sources

Synthesis of 3,5-Disubstituted Isoxazoles and Isoxazolines in Deep Eutectic Solvents [PDF]

, 2015
The synthesis of different 3,5-disubstituted isoxazoles and related isoxazolines using choline chloride:urea as deep eutectic solvent (DES) in a one-pot three step reaction has been accomplished successfully. The use of highly nucleophilic functionalized
Pérez Galera, Juana María, Ramón, Diego J.   +1 more
core   +3 more sources

Mechanochemical Dehalogenative Deuteration of Alkyl Halides Through Piezoelectric Catalysis Initiated by a Single‐Electron Oxidation Strategy

Advanced Science, EarlyView.
A mechanochemical method is developed using D2O and a piezoelectric catalyst to deuterate both activated and unactivated alkyl halides (Cl, Br, I) efficiently. Unlike typical mechanochemical reactions, this one starts with single‐electron oxidation. This green technique successfully deuterates various alkyl halides, including primary, secondary, and ...
Ruiling Qu, Ruoxuan Liu, Xiaochun He, Xuemei Zhang, Zhong Lian   +4 more
wiley   +1 more source

Mechanistic Insight into Para‐Substituent Control of Thermal Half‐Lives in Arylazopyrazole Photoswitches

Angewandte Chemie, EarlyView.
Herein we provide an overview of photochromic and photophysical properties of a broad variety of arylazo‐1,3,5‐trimethylpyrazole photoswitches, including the influence of 23 different para‐substituents. Measured half‐lives correlated in a Hammet plot are rationalized by density functional theory calculations, revealing the underlying thermal ...
Katharina Schlögl, Nadja K. Singer, Dominik Dreier, Hubert Kalaus, Rafaela C. O. Conceição, Marko D. Mihovilovic, Leticia González   +6 more
wiley   +2 more sources

The Structure of Nitro‐ and Polynitropyrazoles: X‐Ray Crystallography Versus Theoretical Calculations

Asian Journal of Organic Chemistry, EarlyView.
Abstract This publication presents the geometries of 157 nitro‐ and polynitropyrazoles. Among these, 109 compounds were theoretically studied using mainly the B3LYP/6–311++G(d,p) level of theory. Three‐parameter Lee‐Yang‐Parr (B3LYP) is a density functional theory (DFT) method widely used in computational chemistry and constitutes an acceptable ...
Rosa M. Claramunt, Marta Pérez‐Torralba, José Elguero, Ibon Alkorta   +3 more
wiley   +1 more source

N\u3csup\u3e1\u3c/sup\u3e-Acetyl-3\u27-methylandrosta-4,16-dieno[16,17-\u3cem\u3ed\u3c/em\u3e]pyrazole-3-one [PDF]

, 1994
In an attempt to find the structural features promoting the thermal isomerization of the N-acylated steroid [16,17-d]pyrazoles into [17,16-c]pyrazole derivatives,the X-ray structure analysis of the title compound, C23H30N2O3, (1), has been carried out ...
Kamernitzky, Alexey V., Lindeman, Sergey V., Nava, Ezequiel Huipe, Skorova, Alina V., Vesela, Irina V., Yanovsky, Alexandr I.   +5 more
core   +1 more source

Die Kombination von induktiven Effekten und Dispersionskräften erhöht die bioorthogonale Reaktivität von Tetrazinen gegenüber Isonitrilen

Angewandte Chemie, EarlyView.
Substituenten, die gleichzeitig sperrig und elektronenziehend sind, können sowohl die Reaktivität von Tetrazinen gegenüber Isonitrilen als auch deren Stabilität erhöhen und damit eine zentrale Herausforderung der bioorthogonalen Chemie überwinden.
Suprakash Biswas, Andreas Löffler, Pushkar Bansal, Randall T. Peterson, Dennis Svatunek, Raphael M. Franzini   +5 more
wiley   +1 more source

Antioxidant and antimicrobial properties of 2-(4,5-dihydro-1H-pyrazol-1-yl)-pyrimidine and 1-carboxamidino-1H-pyrazole derivatives [PDF]

, 2010
Five previously synthesized 4-trifluoromethyl-2-(5-aryl-3-styryl-1H-pyrazol-1yl)-pyrimidines and six 5-aryl-3-styryl-1-carboxamidino-1H-pyrazole derivatives were screened for their antioxidant proprieties.
COLEPICOLO, Pio, FLORES, Alex F. C., FLORES, Darlene C., GRESSLER, Vanessa, MOURA, Sidnei, PINTO, Ernani   +5 more
core   +1 more source

Study of synthesis of 2-(2-alkoxyphenyl)-1H-imidazoles. Comparison of oxidative aromatization reactions of imidazolines [PDF]

, 2006
The reaction of methyl salicylate with ethane-1,2-diamine has been used to prepare 2-(2-hydroxyphenyl)-1H-imidazoline. This compound was alkylated with alkyl halides to give five new 2-(2-alkoxyphenyl)-1H-imidazolines (alkyl = propyl, isopropyl, isobutyl,
Handlíř, Karel, Lišková, Vlasta, Ludwig, Miroslav, Pařík, Patrik, Šenauerová, Sylva   +4 more
core   +2 more sources