Crystal structure of [1,2,4] triazolo[4,3- b ]pyridazine derivatives as BRD4 bromodomain inhibitors and structure–activity relationship study [PDF]
Scientific Reports, 2023 BRD4 contains two tandem bromodomains (BD1 and BD2) that recognize acetylated lysine for epigenetic reading, and these bromodomains are promising therapeutic targets for treating various diseases, including cancers.
Jung-Hoon Kim +7 more
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In silico design of novel pyridazine derivatives as balanced multifunctional agents against Alzheimer’s disease [PDF]
Scientific ReportsAlzheimer’s disease (AD) necessitates innovative therapeutic approaches that target its multifaceted pathology. This study investigates a series of 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives as potential multi-target ligands for AD ...
Mourad Aloui +7 more
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Synthesis of Pyridazine Derivatives by Suzuki-Miyaura Cross-Coupling Reaction and Evaluation of Their Optical and Electronic Properties through Experimental and Theoretical Studies [PDF]
Molecules, 2018 A series of π-conjugated molecules, based on pyridazine and thiophene heterocycles 3a⁻e, were synthesized using commercially, or readily available, coupling components, through a palladium catalyzed Suzuki-Miyaura cross-coupling reaction.
Sara S. M. Fernandes +3 more
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Synthesis of Some New Pyridazine Derivatives for Anti-HAV Evaluation [PDF]
Molecules, 2017 4-(2-(4-Halophenyl)hydrazinyl)-6-phenylpyridazin-3(2H)-ones 1a,b were prepared and treated with phosphorus oxychloride, phosphorus pentasulphide and ethyl chloroformate to give the corresponding chloropyridazine, pyridazinethione, oxazolopyridazine ...
Eman M. Flefel +5 more
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Formal [4 + 2] combined ionic and radical approach of vinylogous enaminonitriles to access highly substituted sulfonyl pyridazines [PDF]
Communications ChemistryPyridazine derivatives hold significant interest due to their broad applications in pharmaceuticals and materials science, where they serve as valuable scaffolds for bioactive compounds and functional materials.
Chanhyun Jung +10 more
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Bis-Pyridazine Derivatives with Anticancer Activity [PDF]
Proceedings, 2019 Over the last decades, pyridazine derivatives are considered “privileged structures” in medicinal chemistry, with special attention being given to pyridazinones derivatives, which were found to have a large range of biological activities ...
Amariucai-Mantu Dorina +3 more
doaj +2 more sources
Molecules, 2021 During the last few decades, pyridazine derivatives have emerged as privileged structures in heterocyclic chemistry, both because of their excellent chemistry and because of their potential applications in medicinal chemistry and optoelectronics.
Dorina Amariucai-Mantu +2 more
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Molecular docking studies of N-substituted 4-methoxy-6-oxo-1-aryl-pyridazine-3-carboxamide derivatives as potential modulators of glutamate receptors [PDF]
Research Results in Pharmacology, 2020 Introduction: The virtual target-oriented screening is a necessary stage of modern drug-design. In the present study, the affinity of pyridazine derivatives for the most promising antiparkinsonian biotargets – I–III groups of metabotropic and ionotropic ...
Hanna I. Severina +5 more
doaj +3 more sources
Pyridazine Derivatives. XI: Antihypertensive Activity of 3-Hydrazinocycloheptyl[1,2-c]pyridazine and Its Hydrazone Derivatives [PDF]
Journal of Pharmaceutical Sciences, 1993 3-Hydrazinocycloheptyl[1,2-c]pyridazine (4) and its hydrazone derivatives 3-[N1-(isopropylidene)]hydrazinocycloheptyl[1,2-c]pyridazine [correction of hydrazinocyclohexyl] (5) and 3-[N1-(isobutylidene)]hydrazinocycloheptyl[1,2-c]pyridazine (6) were prepared, and their activity against genetic, neurogenically-induced, and deoxycorticosterone acetate ...
Gil-Longo, José +8 more
openaire +3 more sources
Heterocyclic synthesis with nitriles: synthesis of pyridazine and pyridopyridazine derivatives [PDF]
, 2007 The reaction of MND with aryldiazonium chlorides followed by cyclization afforded the pyridazinimine derivatives. Reaction of the latter with another mole of malononitrile produce only pyrido[3,2-c]pyridazine derivatives.
Campos, Ana M. F. Oliveira +2 more
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