Results 31 to 40 of about 5,173 (205)

Synthesis and Antibacterial Evaluation of Novel Heterocyclic Compounds Containing a Sulfonamido Moiety

Molecules, 2013
Aiming for the synthesis of new heterocyclic compounds containing a sulfonamido moiety suitable for use as antibacterial agents, the precursor ethyl {[4-N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylazo}cyanoacetate was reacted with a variety of active ...
Eman A. El-Bordany, Mohamed M. Youssef, Mohammad Emad Azab   +2 more
doaj   +1 more source

Enhancement of tripartite synapses as a potential therapeutic strategy for Alzheimer’s disease: a preclinical study in rTg4510 mice

Alzheimer’s Research & Therapy, 2019
Background The lack of effective treatment options for Alzheimer’s disease (AD) is of momentous societal concern. Synaptic loss is the hallmark of AD that correlates best with impaired memory and occurs early in the disease process, before the onset of ...
Joshua B. Foster, Rashelle Lashley, Fangli Zhao, Xueqin Wang, Nydia Kung, Candice C. Askwith, Lin Lin, Michael W. Shultis, Kevin J. Hodgetts, Chien-Liang Glenn Lin   +9 more
doaj   +1 more source

Investigating pyridazine and phthalazine exchange in a series of iridium complexes in order to define their role in the catalytic transfer of magnetisation from para-hydrogen [PDF]

, 2015
The reaction of [Ir(IMes)(COD)Cl], [IMes = 1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene, COD = 1,5-cyclooctadiene] with pyridazine (pdz) and phthalazine (phth) results in the formation of [Ir(COD)(IMes)(pdz)]Cl and [Ir(COD)(IMes)(phth)]Cl.
Abel, Abel, Abel, Abel, Abignente, Adams, Aguilar, Aguilar, Alvarez, Ancian, Atkinson, Atkinson, Barskiy, Bauer, Bax, Bingham, Binsch, Blazina, Bowers, Brorson, Chen, Chen, Cohn, Cowley, Craft, Dixon, Duckett, Duckett, Duecker, Eaton, Eisenschmid, Eshuis, Feeney, Fekete, Gloggler, Gloggler, Golman, Gomtsyan, Green, Green, Harris, Hennig, Hovener, Hovener, Jazzar, Jeener, Johnson, Johnson, Jones, Kang, Kessler, Kuwahara, Lamberth, Livermore, Machado, Martin, Mewis, Natterer, Pazderski, Pogacic, Pravdivtsev, Ryu, Sargent, Sargent, Searles, Shaw, Stonehouse, Stott, Stott, Theis, Torres, Truong, Vassilev, Zeng, Zeng   +74 more
core   +1 more source

An expedient and new synthesis of pyrrolo[1,2-b]pyridazine derivatives

Beilstein Journal of Organic Chemistry, 2009
The reaction of 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid phenylamide with tertiary butyl carbazate and subsequent condensation of the resulting carbamate derivative with a chalcone provided a facile new approach to pyrrolo[
Rajeshwar Reddy Sagyam, Ravinder Buchikonda, Jaya Prakash Pitta, Himabindu Vurimidi, Pratap Reddy Padi, Mahesh Reddy Ghanta   +5 more
doaj   +1 more source

Pyridazin-derivate. VI. Synthese der Derivate des Imidazo [1, 2-b] pyridazins

Chemical and Pharmaceutical Bulletin, 1964
Durch die Einwirkung von phenacylbromiden auf 3-Amino-6-chlorpyridazin wurden verschiedenartige 2-Phenyl-6-chlorimidazo [1, 2-b] pyridazine hergestellt. Das Chloratom der letzteren wurde durch Einwirkung von Na-Alkoholaten, Dialkylaminen bzw. wasr. alkoholischem Kali gegen Alkoxyl-, Dialkylamino- bzw. Hydroxyl-gruppen ausgetaus ht.
Fumio Yoneda, Takayuki Ohtaka, Yoshihiro Nitta   +2 more
openaire   +2 more sources

The Cu(OTf)2 catalysed microwave assisted synthesis of a new scaffold, 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-one [PDF]

, 2014
The synthesis of novel 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-ones is described including a one-step Mannich-type reaction followed by intramolecular ring closure of ethyl 3-methylpyridazine-4- carboxylate and aldimines, catalysed by the Lewis ...
De Coen, Laurens, Jatczak, Martyna, Mangelinckx, Sven, Muylaert, Koen, Stevens, Christian, Van Hecke, Kristof   +5 more
core   +2 more sources

Study on the Acid⁃Catalyzed Cyclization Reaction of Allylbenzenes and Tetrazine

Shiyou huagong gaodeng xuexiao xuebao
Indeno[1,2⁃d]pyridazine derivatives have wide applications in pesticides,pharmaceuticals,and other fields due to their excellent biological activities.Therefore,the development of rapid and efficient synthetic methods for these compounds has attracted ...
Wenqing LIU, He WANG, Xin WANG, Lei LI
doaj   +1 more source

Synthesis and Antifungal Activity of 5-Chloro-6-Phenylpyridazin-3(2H)-one Derivatives

Molecules, 2009
An effective method has been developed for the preparation under mild conditions of novel pyridazine derivatives from the easily accessible starting materials mucochloric acid and benzene.
Deyu Hu, Pinaki Bhadury, Hongjun Chen, Jian Wu, Baoan Song   +4 more
doaj   +1 more source

Pyridazinone Compounds: A Mini review on their antifungal activities

International Journal of New Chemistry, 2020
Pyridazine derivatives represent one of the most active classes of compounds possessing a wide spectrum of biological activity. They are widely used in pharmaceuticals and agrochemicals.
Mohammad Asif Abida , Md Tauquir Alam
doaj   +1 more source

Empirical LCAO parameters for $\pi$ molecular orbitals in planar organic molecules

, 2008
We present a parametrization within a simplified LCAO model (a type of Hueckel model) for the description of $\pi$ molecular orbitals in organic molecules containing $\pi$-bonds between carbon, nitrogen, or oxygen atoms with $sp^2$ hybridization, which ...
Hawke, Laurence, Kalosakas, George, Simserides, Constantinos   +2 more
core   +3 more sources