Results 81 to 90 of about 5,173 (205)

Synthesis of 2,5-Diiodopyrazine by Deprotonative Dimetalation of Pyrazine

, 2008
International audienceThe deproto-metalation reactions of pyrimidine and pyrazine were regioselectively carried out using lithium tri(2,2,6,6-tetramethylpiperidino)cadmate in tetrahydrofuran at room temperature. This result was demonstrated by subsequent
Bentabed-Ababsa, Ghenia, Chevallier, Floris, Derdour, Aïcha, L'Helgoual'Ch, Jean-Martial, Mongin, Florence   +4 more
core   +3 more sources

Highly efficient deep‐blue organic light‐emitting diodes with high color‐purity enabled by triptycene‐enhanced rigid Pt(II) complexes

FlexMat, Volume 2, Issue 4, Page 630-642, December 2025.
Novel enhanced‐rigid tetradentate Pt(II) emitters were developed via the first strategic merging of a pyramidal triptycene unit into the 2,3‐positions of the carbazole moiety. PtJY2‐based bottom‐emitting PhOLED represents one of the best‐balanced performances, including excellent EQEs, low roll‐off, and high color purity, among the reported non ...
Jiaoying Lin, Kewei Xu, Hongjian Zheng, Yuanbin She, Guijie Li   +4 more
wiley   +1 more source

Reactivity and Synthetic Applications of 4,5-Dicyanopyridazine: An Overview

Molecules, 2010
Despite the poor reputation of electron-deficient pyridazines in intermolecular Hetero Diels-Alder (HDA) reactions, 4,5-dicyanopyridazine (DCP) showed a surprising reactivity as a heterocyclic azadiene in inverse electron-demand HDA processes with ...
Donatella Giomi, Marco Cecchi, Renzo Alfini   +2 more
doaj   +1 more source

Recent Synthetic Advances in C–H/N–H Functionalization of 1H‐Pyrazoles: Diverse Strategies Across Variously Substituted Scaffolds

The Chemical Record, Volume 25, Issue 12, December 2025.
Systematic overview of pyrazole functionalization reactions from C‐5 to N−H. It covers different strategies, from traditional cross‐coupling of prefunctionalized pyrazoles to more efficient direct functionalizations. This review briefly and systematically overviews C–H and N–H functionalization reactions of pyrazoles, aimed at creating new CC and C ...
Karolina Dzedulionytė Müldür, Asta Žukauskaitė, Algirdas Šačkus, Eglė Arbačiauskienė   +3 more
wiley   +1 more source

Novel 1,4-benzoxazine and 1,4-benzodioxine inhibitors of angiogenesis. [PDF]

, 2012
Esters of 1,4-benzoxazine and 1,4-benzodioxine compounds 1 and 10, which combine thrombin inhibitory and GPIIb/IIIa antagonistic activity in one molecule are shown to inhibit endothelial cell migration and tube formation in vitro and angiogenesis in the ...
Andrej Boháč, Arnaoutova, Auerbach, Carmeliet, Caunt, Crawford, Cristofanilli, Danijel Kikelj, Ebos, Ferrara, Ferro, Folkman, Ilaš, Ilić, Ilić, Janez Ilaš, Khachigian, Liekens, Miloš Ilić, Nierodzik, Nierodzik, Pennacchietti, Petra Dunkel, Prins, Pàez-Ribes, Péter Mátyus, Rhee, Sabrkhany, Samant, Sandra Liekens, Sleeman, Sorensen, Staton, Steeg, Tsopanoglou, Tsopanoglou, Štefanič Anderluh   +36 more
core   +1 more source

Transition Metal‐Free Ortho‐Deuteration of Electron‐Deficient N‐Heteroarenes

European Journal of Organic Chemistry, Volume 28, Issue 42, November 20, 2025.
Herin, the metal‐free, selective deuteration of electron‐deficient N‐heteroaromatics is reported using O‐carbamate and carboxamide ortho‐directing groups (DGs), lithium 2,2,6,6‐tetramethylpiperidide as the base, and D2O as a green source of D+. The substrate scope includes 10 small molecule N‐heteroaromatic compounds and two pharmaceutically relevant ...
Žiga Oražem, Luka Jedlovčnik, Jernej Birk, Andrej Pevec, Ross D. Jansen‐van Vuuren, Janez Košmrlj   +5 more
wiley   +1 more source

One pot synthesis of pyrrolidines type 3,7-diazabicyclo [3.3.0] octane and biological activity [PDF]

, 2008
Pyrrolidines type 2,4-disubstituted (alkyl, aryl or heteroaryl)-6,8-dioxo-3,7-diazabicyclo [3.3.0] octanes (8a-d) were successfully synthesized by an efficient one pot 1,3-dipolar cycloaddition of azomethine ylides (in situ generated from the reaction of
Amornraksa, Kitti, Prachayasittikul, Virapong, Worachartcheewan, Apilak   +2 more
core  

A Minimal, Unstrained S-Allyl Handle for Pre-Targeting Diels-Alder Bioorthogonal Labeling in Live Cells [PDF]

, 2016
The unstrained S-allyl cysteine amino acid was site-specifically installed on apoptosis protein biomarkers and was further used as a chemical handle and ligation partner for 1,2,4,5-tetrazines by means of an inverse-electron-demand Diels-Alder reaction ...
,, Bernardes, GJL, Boutureira, O, Guerreiro, A, Guo, Z, Jiménez-Osés, G, Oliveira, BL   +6 more
core   +4 more sources

Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Pyridazine scaffolds are considered privileged structures pertaining to its novelty, chemical stability, and synthetic feasibility. In our quest towards the development of novel scaffolds for effective vascular endothelial growth 2 (VEGFR-2) inhibition ...
Maiy Y. Jaballah, Rabah A. T. Serya, Nasser Saad, Sohair M. Khojah, Marawan Ahmed, Khaled Barakat, Khaled A. M. Abouzid   +6 more
doaj   +1 more source

Direct metalation of heteroaromatic esters and nitriles using a mixed lithium-cadmium base. Subsequent conversion to dipyridopyrimidinones. [PDF]

, 2010
International audienceAll pyridine nitriles and esters were metalated at the position next to the directing group using (TMP)(3)CdLi in tetrahydrofuran at room temperature.
Bentabed-Ababsa, Ghenia, Chevallier, Floris, Derdour, Aïcha, Hesse, Stéphanie, Mongin, Florence, Nassar, Ekhlass, Nguyen, Tan Tai, Sidaty Cheikh Sid, Ely   +7 more
core   +3 more sources