Results 31 to 40 of about 8,502 (208)
The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one
Molecules, 2003 3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4 ...
Masahiro Ariga +4 more
doaj +1 more source
Route Exploration and Synthesis of the Reported Pyridone-Based PDI Inhibitor STK076545 [PDF]
, 2020 The enzyme protein disulfide isomerase (PDI) is essential for the correct folding of proteins and the activation of certain cell surface receptors, and is a promising target for the treatment of cancer and thrombotic conditions.
Eric, Greve +2 more
core +2 more sources
Rhodium(I)-Complexes Catalyzed 1,4-Conjugate Addition of Arylzinc Chlorides to N-Boc-4-pyridone
Molecules, 2017 Rhodium(I)-complexes catalyzed the 1,4-conjugate addition of arylzinc chlorides to N-Boc-4-pyridone in the presence of chlorotrimethylsilane (TMSCl). A combination of [RhCl(C2H4)2]2 and BINAP was determined to be the most effective catalyst to promote ...
Fenghai Guo +5 more
doaj +1 more source
Synthesis of 5-(substituted phenylazo)-6-hydroxy-4-methyl-3-cyano-2-pyridones from ethyl 3-oxo-2-(substituted phenylazo)butanoates, Short communication [PDF]
Journal of the Serbian Chemical Society, 2011 A new procedure for the synthesis of known azo pyridone dyes is presented. A series of 5-(substituted arylazo)-6-hydroxy-4-methyl-3-cyano-2-pyridones were prepared from ethyl 3-oxo-2-(substituted phenylazo)butanoates and cyanoacetamide in acetone using ...
GORDANA UŠĆUMLIĆ +3 more
doaj
Rapidly Diversifying Hydrogen‐Bonded Organic Frameworks With Permanent Porosity
Angewandte Chemie, Volume 138, Issue 36, 1 September 2026.This article reviews diversifying hydrogen‐bonded organic frameworks (HOFs) with permanent porosity reported over the past 15 years, based on the molecular structures of their constituent tectons. Furthermore, several distinctive aspects and concepts are described, such as permanent porosity, isostructural (isoreticular) HOFs, and multicomponent mixed ...
Taito Hashimoto, Ichiro Hisaki
wiley +2 more sources
5,5’-Selenobis(1-benzyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde)
MolbankSelenium compounds have garnered significant attention in the field of medicinal chemistry due to their unique biochemical properties and potential therapeutic applications for different pathologies.
Emeline Grosjean +5 more
doaj +1 more source
Heterocyclic Communications, 2022 2-Pyridone is considered as one of the most famous efficient pharmaceutical compounds. Many approaches were discovered to synthesize 2-pyridone. In this present research, chloroacetylation of benzylamine at simple conditions, EtONa/EtCOONa produced N ...
Hamed Eman O. +4 more
doaj +1 more source
, 2011 The excitonic splitting between the S-1 and S-2 electronic states of the doubly hydrogen-bonded dimer 2-pyridone center dot 6-methyl-2-pyridone (2PY center dot 6M2PY) is studied in a supersonic jet, applying two-color resonant two-photon ionization (2C ...
Ottiger, P. +7 more
core +1 more source
Potential role of PIM1 inhibition in the treatment of SARS-CoV-2 infection
Journal of Genetic Engineering and Biotechnology, 2023 Background SARS-CoV-2 infection involves disturbing multiple molecular pathways related to immunity and cellular functions. PIM1 is a serine/threonine-protein kinase found to be involved in the pathogenesis of several viral infections. One PIM1 substrate,
Magda M. F. Ismail +8 more
doaj +1 more source
Porous Carbon Materials for Carbon Dioxide Capture
Carbon Energy, EarlyView.This work aims to address the current status and challenges associated with the regulation of pore structures, as well as the influence of pore structures on CO2 capture. Systematic quantitative analysis of structure–property relationships, combined with machine learning approaches, can effectively evaluate the contributions of structural ...
Zhifu Liu +6 more
wiley +1 more source