Results 41 to 50 of about 7,582 (216)

A New N-methoxypyridone from the Co-Cultivation of Hawaiian Endophytic Fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062

Molecules, 2017
A new N-methoxypyridone analog (1), together with four known compounds, was isolated from the co-culture of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062.
Chunshun Li, Ariel M. Sarotti, Baojun Yang, James Turkson, Shugeng Cao   +4 more
doaj   +1 more source

4-Pyridone-3-carboxamide-1-β-d-ribonucleoside Triphosphate (4PyTP), a Novel NAD+ Metabolite Accumulating in Erythrocytes of Uremic Children: A Biomarker for a Toxic NAD+ Analogue in Other Tissues?

Toxins, 2011
We have identified a novel nucleotide, 4-pyridone 3/5-carboxamide ribonucleoside triphosphate (4PyTP), which accumulates in human erythrocytes during renal failure.
Elizabeth A. Carrey, Ryszard T. Smolenski, H. Anne Simmonds, Ewa M. Slominska, Lynnette D. Fairbanks, Elena Synesiou   +5 more
doaj   +1 more source

Biological evaluation of pyridone alkaloids on the endocannabinoid system [PDF]

, 2017
Naturally occurring pyridone alkaloids as well as synthetic derivatives were previously shown to induce neurite outgrowth. However, the molecular basis for this biological effect remains poorly understood.
Marck, Nicolas, Chicca, Andrea, Regina Berg, Burch, Patrick, Jessen, Henning J, Nicolas Marck, Jessen, Henning, Fabian Schmid, Patrick Burch, Gertsch, Jürg, Jürg Gertsch, Karl Gademann, Gademann, Karl, Berg, Regina, Henning J. Jessen, Andrea Chicca, Schmid, Fabian   +16 more
core   +1 more source

3-Cyano-4,6-dimethyl-2-pyridone (Guareschi pyridone)

Acta Crystallographica Section E Structure Reports Online, 2004
In the crystal structure of the title compound, C8H8N2O, the mol­ecules form centrosymmetric dimers via N—H⋯O hydrogen bonds.
Victor B. Rybakov, Alexander A. Bush, Eugene V. Babaev, Leonid A. Aslanov   +3 more
openaire   +1 more source

Ambident Reactivities of Pyridone Anions

, 2016
The kinetics of the reactions of the ambident 2- and 4-pyridone anions with benzhydrylium ions (diarylcarbenium ions) and structurally related Michael acceptors have been studied in DMSO, CH3CN, and water.
Herbert Mayr (1353507), Martin Breugst (1316103)   +1 more
core   +2 more sources

Synthesis of 5-(substituted phenylazo)-6-hydroxy-4-methyl-3-cyano-2-pyridones from ethyl 3-oxo-2-(substituted phenylazo)butanoates, Short communication [PDF]

Journal of the Serbian Chemical Society, 2011
A new procedure for the synthesis of known azo pyridone dyes is presented. A series of 5-(substituted arylazo)-6-hydroxy-4-methyl-3-cyano-2-pyridones were prepared from ethyl 3-oxo-2-(substituted phenylazo)butanoates and cyanoacetamide in acetone using ...
GORDANA UŠĆUMLIĆ, DUŠAN MIJIN, NATAŠA VALENTIĆ, JASMINA DOSTANIĆ   +3 more
doaj  

Cyclization of N-acetyl derivative: Novel synthesis – azoles and azines, antimicrobial activities, and computational studies

Heterocyclic Communications, 2022
2-Pyridone is considered as one of the most famous efficient pharmaceutical compounds. Many approaches were discovered to synthesize 2-pyridone. In this present research, chloroacetylation of benzylamine at simple conditions, EtONa/EtCOONa produced N ...
Hamed Eman O., Assy Mohamed G., Ouf Nabil H., Elsayed Doaa A., Abdellattif Magda H.   +4 more
doaj   +1 more source

Potential role of PIM1 inhibition in the treatment of SARS-CoV-2 infection

Journal of Genetic Engineering and Biotechnology, 2023
Background SARS-CoV-2 infection involves disturbing multiple molecular pathways related to immunity and cellular functions. PIM1 is a serine/threonine-protein kinase found to be involved in the pathogenesis of several viral infections. One PIM1 substrate,
Magda M. F. Ismail, Rehab R. El-Awady, Amal M. Farrag, Sara H. Mahmoud, Noura M. Abo Shama, Ahmed Mostafa, Mohamed A. Ali, Mohammed H. Rashed, Iman H. Ibrahim   +8 more
doaj   +1 more source

The S-1/S-2 exciton interaction in 2-pyridone center dot 6-methyl-2-pyridone: Davydov splitting, vibronic coupling, and vibronic quenching

, 2011
The excitonic splitting between the S-1 and S-2 electronic states of the doubly hydrogen-bonded dimer 2-pyridone center dot 6-methyl-2-pyridone (2PY center dot 6M2PY) is studied in a supersonic jet, applying two-color resonant two-photon ionization (2C ...
Ottiger, P., Leutwyler, S., Heid, C. G., Philipp Ottiger, Leist, R., Cornelia G. Heid, Roman Leist, Samuel Leutwyler   +7 more
core   +1 more source

Continuous flow synthesis of some 6- and 1,6-substituted 3-cyano-4-methyl-2-pyridones [PDF]

Journal of the Serbian Chemical Society, 2019
In this study, six 6- and 1,6-substituted-3-cyano-4-methyl-2-pyridones were synthesized in a continuous flow microreactor system. The syntheses were realized at room temperature and the obtained results were compared to those achieved within classical ...
Tadić Julijana, Mihajlović Marina, Jovanović Mića, Mijin Dušan   +3 more
doaj   +1 more source