Results 51 to 60 of about 7,582 (216)
New Pyridone-Based Derivatives as Cannabinoid Receptor Type 2 Agonists [PDF]
, 2021 The activation of the human cannabinoid receptor type II (CB2R) is known to mediate analgesic and anti-inflammatory processes without the central adverse effects related to cannabinoid receptor type I (CB1R).
Faundez Parraguez, Manuel +16 more
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Beilstein Journal of Organic Chemistry, 2012 A core 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-one scaffold is elaborated at C-3(Me) by base-mediated aldol condensation to give new 3-alkenyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-ones, which are masked forms related to the acylpyridone ...
Raymond C. F. Jones +5 more
doaj +1 more source
Late‐Stage Functionalization of Peptides on the Solid Phase
Angewandte Chemie International Edition, EarlyView.Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner +2 more
wiley +1 more source
Biosynthesis of (–)-Sambutoxin, a Fusarium 2-Pyridone Alkaloid Mycotoxin [PDF]
, 2021 This dissertation describes the discovery by genome mining and the characterization of thebiosynthetic pathway for sambutoxin, a 4-hydroxy-2-pyridone alkaloid Fusarium mycotoxin.
Go, Louise
core
SYNTHESIS AND ANTIHYPERLIPIDEMIC ACTIVITY OF CERTAIN NICOTINIC ACID DERIVATIVES [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2005 3-Ethoxycarbonyl-4,6-dimethyl-2(1H)-pyridone I was prepared and converted to the corresponding sodium salt II. The latter reacted with certain chloroacetanilides to afford the corresponding ethers III.
Mohamed Abdel-Wahab +1 more
doaj +1 more source
Route Exploration and Synthesis of the Reported Pyridone-Based PDI Inhibitor STK076545
, 2020 The enzyme protein disulfide isomerase (PDI) is essential for the correct folding of proteins and the activation of certain cell surface receptors, and is a promising target for the treatment of cancer and thrombotic conditions.
Eric, Greve +2 more
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Acta Crystallographica Section E: Crystallographic Communications, 2017 In the title compound, C21H17N5O3S3·C3H7NO, the toluenesulfonamide ring and the combined ring system involving the pyridone and benzothiazole rings subtend an interplanar angle of 39.86 (4)°.
Rasha A. Azzam +3 more
doaj +1 more source
Porous Carbon Materials for Carbon Dioxide Capture
Carbon Energy, EarlyView.This work aims to address the current status and challenges associated with the regulation of pore structures, as well as the influence of pore structures on CO2 capture. Systematic quantitative analysis of structure–property relationships, combined with machine learning approaches, can effectively evaluate the contributions of structural ...
Zhifu Liu +6 more
wiley +1 more source
Synthesis of 2-Pyridone Derivatives Bearing an Electron-withdrawing Group on Nitrogen [PDF]
, 2007 1-Protected 2(1H)-pyridones are highly useful dienophiles because Diels-Alder reaction of 1-sulfonyl-2(1H)-pyridones gave the synthetic intermediate such as quinoline and isoquinoline derivatives.
渡邉, 一弘 +8 more
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Conservation of the Hydrogen-Bonded Pyridone Homosynthon in Halogen-Bonded Cocrystals
, 2022 Seven cocrystals of pyridone and perfluorinated halocarbons have been prepared. In all cases pairs of pyridone molecules are connected into dimers by two N–H···O hydrogen bonds, forming the characteristic pyridone homosynthon of R22(8) topology.
Luka Fotović +7 more
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