Results 181 to 190 of about 16,008 (266)

Bioevaluation of synthetic pyridones as dual inhibitors of α‐amylase and α‐glucosidase enzymes and potential antioxidants

Archiv der Pharmazie, 2022
Herein, a library of novel pyridone derivatives 1–34 was designed, synthesized, and evaluated for α‐amylase and α‐glucosidase inhibitory as well as antioxidant activities.
F. Saleem, K. Khan, N. Ullah, M. Özil, N. Baltaş, S. Hameed, U. Salar, A. Wadood, A. Rehman, Mukesh Kumar, M. Taha, S. M. Haider   +11 more
semanticscholar   +1 more source

Ruthenium-Catalyzed Chemoselective N-H Bond Insertion Reactions of 2-Pyridones/7-Azaindoles with Sulfoxonium Ylides.

Organic Letters, 2021
A ruthenium-catalyzed highly chemoselective N-alkylation of 2-pyridones has been developed, affording N-alkylated 2-pyridone derivatives in good yields and excellent N-selectivity.
Xiaofeng Liu, Y. Shao, Jiangtao Sun
semanticscholar   +1 more source

Chemo- and Enantioselective Insertion of Furyl Carbene into the N-H Bond of 2-Pyridones.

Angewandte Chemie, 2021
Asymmetric carbene insertion reactions represent one of the most important protocols to construct carbon-heteroatom bonds. The use of donor-acceptor diazo compounds bearing an ester group is however a prerequisite for achieving high enantioselectivity ...
Kai Wang, Zi‐Ye Liu, Guangyang Xu, Y. Shao, S. Tang, Ping-Fan Chen, Xinhao Zhang, Jiangtao Sun   +7 more
semanticscholar   +1 more source

Chemoselective N- and O-Difluoromethylation of 2-Pyridones, Isoquinolinones, and Quinolinones with TMSCF2Br.

Organic Letters, 2021
An operationally simple protocol for direct N- and O-difluoromethylation of 2-pyridones, quinolinones, and isoquinolinones using commercially available TMSCF2Br is disclosed. The chemoselectivity is modulated by simple variations in temperature, solvent,
Ziyue Zhu, V. Krishnamurti, Xanath Ispizua-Rodriguez, C. Barrett, G. Prakash   +4 more
semanticscholar   +1 more source

Copper-Catalyzed Regioselective Coupling of Tosylhydrazones and 2-Pyridones: A Strategy for the Production of N-Alkylated Compounds.

Journal of Organic Chemistry, 2021
The highly regioselective N-alkylation reaction of 2-pyridones was achieved through hydrazone chemistry, especially for substrates with bulky secondary alkyl groups.
Ye-bin Wu, Youzhi Wu, Jian Wu, Danqian Xu, Hui Jiang, Wenxu Chang, Chang-You Ma   +6 more
semanticscholar   +1 more source

Ligand-Controlled Ni(0)–Al(III) Bimetal-Catalyzed C3–H Alkenylation of 2-Pyridones by Reversing Conventional Selectivity

, 2021
Conventional C–H alkenylation with alkynes via low-valent transition-metal catalysis occurs at the C6 or C4 position of 2-pyridone with electron-deficient C–H bonds.
Ge Yin, Yue Li, Rong-Hua Wang, Jiangting Li, Xuetao Xu, Yu-Xin Luan, Mengchun Ye   +6 more
semanticscholar   +1 more source

ChemInform Abstract: PHOTOISOMERIZATION OF 4‐PYRIDONES TO 2‐PYRIDONES

Chemischer Informationsdienst, 1974
AbstractBestrahlung (Hg‐Mitteldrucklampe) der 4‐Pyridone (I) liefert die isomeren 2‐Pyridone (II) als Hauptprodukte, während die 4‐Pyridone (III) unter gleichen Bedingungen unverändert bleiben.
Nobuyuki Ishibe, Jun Masui
openaire   +3 more sources

Lithiation of pyridones

Journal of the Chemical Society, Chemical Communications, 1985
AbstractDie selektive Lithiiemng des N‐Methylpyridons (I) und anschließende Umsetzung von (II) mit Elektrophilen ergibt die Z‐sulastittnierten Pyridone (III).
Premji Patel, John A. Joule
openaire   +3 more sources

4-Hydroxy Pyridones from Heterologous Expression and Cultivation of the Native Host.

Journal of Natural Products, 2020
4-Hydroxy pyridones are a class of fungi-derived polyketide-nonribosomal peptide products featuring a core of 4-hydroxy-2-pyridone which have a wide range of biological activities.
Wei-Yang Zhang, Yue Zhong, Yang Yu, Dan-feng Shi, Huiyun Huang, Xiao-Long Tang, Yongheng Wang, Guo-dong Chen, Hui-ping Zhang, Chenli Liu, Dan Hu, Hao Gao, X. Yao   +12 more
semanticscholar   +1 more source

Pyridones as Potential Antitumor Agents II: 4-Pyridones and Bioisosteres of 3-Acetoxy-2-pyridone

Journal of Pharmaceutical Sciences, 1980
Pyridone structural requirements for activity against murine P-388 leukemia have been extended to isosteric analogs of 3-hydroxy-4-pyridone, a compound previously found to have activity. An amino group can be substituted for the 3-hydroxyl function with retention of activity.
John S. Driscoll, George R. Proctor, George R. Proctor, Deng R. Hwang   +3 more
openaire   +3 more sources