Purine limitation prevents the exogenous pyridoxal 5′-phosphate accumulation of Salmonella enterica yggS mutants [PDF]
Microbiology SpectrumYggS belongs to the highly conserved pyridoxal 5′-phosphate (PLP) binding protein family (COG0325) that is found in all domains of life. Though no precise biochemical activity or molecular mechanism has been determined for this protein, an involvement in
Kailey S. Ezekiel, Diana M. Downs
doaj +2 more sources
Native Microbiome Members of C. elegans Act Synergistically in Biosynthesis of Pyridoxal 5′-Phosphate [PDF]
Metabolites, 2022 The roles of the healthy microbiome on the host and the relationships between members of the microbiome remain to be fully characterized. Due to the complexity of the interactions between the mammalian microbiome and its host, the use of model organisms ...
Orçun Haçariz +3 more
doaj +2 more sources
Synthesis and Structure-Activity Relationships of Pyridoxal-6-arylazo-5'-phosphate and Phosphonate Derivatives as P2 Receptor Antagonists. [PDF]
, 1998 Novel analogs of the P2 receptor antagonist pyridoxal-5'-phosphate-6-phenylazo-2',4'-disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the ...
Boyer, José L. +13 more
core +4 more sources
Current Advances on Structure-Function Relationships of Pyridoxal 5′-Phosphate-Dependent Enzymes
Frontiers in Molecular Biosciences, 2019 Pyridoxal 5′-phosphate (PLP) functions as a coenzyme in many enzymatic processes, including decarboxylation, deamination, transamination, racemization, and others.
Qian Han, Jianyong Li
exaly +3 more sources
Three serendipitous pathways in E. coli can bypass a block in pyridoxal‐5′‐phosphate synthesis [PDF]
Molecular Systems Biology, 2010 Bacterial genomes encode hundreds to thousands of enzymes, most of which are specialized for particular functions. However, most enzymes have inefficient promiscuous activities, as well, that generally serve no purpose.
Juhan Kim +4 more
doaj +2 more sources
Stereoselective Biocatalytic α-Deuteration of L-Amino Acids by a Pyridoxal 5'-Phosphate-Dependent Mannich Cyclase. [PDF]
Chembiochem, 2023 Gao J, Zhou C, Hai Y.
europepmc +3 more sources
Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study. [PDF]
Ther Adv Chronic DisXuan C +6 more
europepmc +2 more sources
A novel phosphatase specific for pyridoxal 5â²-phosphate in an aerobic photosynthetic bacterium, Erythrobacter sp. OCh 114 [PDF]
FEMS Microbiology Letters, 1988 Abstract An acid phosphatase highly spcific for pyridoxal 5′-phosphate (PLP) was found and partially purified from the aerobic photosynthetic bacterium, Erythrobacter sp. OCh 114. The enzyme showed a pH optimum at 5.5; its activity was stimulated by magnesium ions.
null Michio Doi, null Yuzo Shioi
openaire +1 more source
Simultaneous Determination of Underivatized Vitamin B1 and B6 in Whole Blood by Reversed Phase Ultra High Performance Liquid Chromatography Tandem Mass Spectrometry. [PDF]
PLoS ONE, 2015 Vitamin B1 (thiamine-diphosphate) and B6 (pyridoxal-5'phosphate) are micronutrients. Analysis of these micronutrients is important to diagnose potential deficiency which often occurs in elderly people due to malnutrition, in severe alcoholism and in ...
Johan Puts +3 more
doaj +1 more source
High catalytic activity of alanine racemase from psychrophilicBacillus psychrosaccharolyticusat high temperatures in the presence of pyridoxal 5â²-phosphate [PDF]
FEMS Microbiology Letters, 2000 We examined the effect of the pyridoxal 5'-phosphate (PLP) cofactor on the activity and stability of the psychrophilic alanine racemase, having a high catalytic activity at low temperature, from Bacillus psychrosaccharolyticus at high temperatures. The decrease in the enzyme activity at incubation temperatures over 40 degrees C was consistent with the ...
Y, Okubo +4 more
openaire +2 more sources