Results 91 to 100 of about 40,643 (298)

Mammalian Tolerance to Amino Acid Heterochirality

ChemBioChem, Accepted Article.
Organisms use amino acids predominantly in l‐configuration. On the other hand, a series of studies show that a variety of d‐amino acids also occur in mammals and amino acid homochirality is not complete. Mammals de novo synthesize most amino acids with l‐configuration, but serine and aspartate are converted from l‐ to d‐configuration by endogenous ...
Jumpei Sasabe, Sakiko Taniguchi, Kenichiro Adachi, Xuan Tran, Masataka Suzuki   +4 more
wiley   +1 more source

Identification of atropine-and P2X1 receptor antagonist-reistant, neurogenic contractions of the urinary bladder [PDF]

, 2007
Acetylcholine and ATP are excitatory cotransmitters in parasympathetic nerves. We used P2X1 receptor antagonists to further characterize the purinergic component of neurotransmission in isolated detrusor muscle of guinea pig urinary bladder.
Gallagher, Gemma, Kennedy, Charles, Tasker, Paul N., Westfall, Timothy D.   +3 more
core   +1 more source

Biosynthesis of Ephedrine is Initiated by Pyridoxal Phosphate‐Dependent Formation of Cathinone

ChemBioChem, Accepted Article.
Ephedra alkaloids possess some of the most basic structures of alkaloids. Despite their importance for human use and their commercial relevance, the biosynthesis of ephedra alkaloids has remained enigmatic. The predominant biosynthetic pathway in the literature proposes a thiamine‐dependent caboligation followed by a transaminase, although no candidate
Karina Witte, Anne Behrens, Hannes M. Schwelm, Volker Auwärter, Michael Müller   +4 more
wiley   +1 more source

Immediate-type hypersensitivity to pyridoxal 5'- phosphate: Study of in vivo and in vitro cross-reactivity and identification of the antigenic determinant

Allergology International, 2001
Background: A case in which a 45-year-old female patient with peritonitis experienced immediate-type hypersensitivity on two occasions after administration of preparations containing six different medications was referred to us for closer inspection ...
Masako Osada, Noriko Oki, Yukari Okubo, Tsunao Oh-i, Michiyuki Koga, Sadao Arai   +5 more
doaj   +1 more source

Dissecting the Hydrolytic Activities of Sarcoplasmic Reticulum ATPase in the Presence of Acetyl Phosphate [PDF]

J Biol Chem . 2002 Oct 11;277(41):38127-32
Sarcoplasmic reticulum vesicles and purified Ca$^{2+}$-ATPase hydrolyze acetyl phosphate both in the presence and absence of Ca$^{2+}$. The Ca$^{2+}$-independent activity was fully sensitive to vanadate, insensitive to thapsigargin, and proceeded without accumulation of phosphorylated enzyme.
arxiv   +1 more source

Conformational Dependence of a Protein Kinase Phosphate Transfer Reaction [PDF]

, 2004
Atomic motions and energetics for a phosphate transfer reaction catalyzed by the cAMP-dependent protein kinase (PKA) are calculated by plane-wave density functional theory, starting from structures of proteins crystallized in both the reactant conformation (RC) and the transition-state conformation (TC).
arxiv   +1 more source

Nodding syndrome in Tanzania may not be associated with circulating anti-NMDA- and anti-VGKC receptor antibodies or decreased pyridoxal phosphate serum levels-a pilot study [PDF]

, 2014
Background: Nodding syndrome (NS) is a seemingly progressive epilepsy disorder of unknown underlying cause. We investigated association of pyridoxal-phosphate serum levels and occurrence of anti-neuronal antibodies against N-methyl-D-aspartate (NMDA ...
Deisenhammer, F, Dietmann, A, Friedrich, K, Griesmacher, A, JilekAall, L, König, R, Matuja, W, Pfausler, B, Schmutzhard, E, Seger, C, Wallner, B, Winkler, AS   +11 more
core   +2 more sources

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Characterization of gut microbiome composition in Iranian patients with nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Scientific Reports, 2023
Gut microbiota dysbiosis is intimately associated with development of non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).
Sara Abdollahiyan, Ali Nabavi-Rad, Shahrbanoo Keshavarz Azizi Raftar, Magali Monnoye, Naghmeh Salarieh, Azam Farahanie, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali, Behzad Hatami, Philippe Gérard, Abbas Yadegar   +10 more
doaj   +1 more source

Effect of pyridoxal phosphate on the DNA binding site of activated hepatic glucocorticoid receptor [PDF]

, 1978
The binding of rat liver glucocorticoid.receptor complexes to DNA-cellulose and nuclei has been studied after activation of the complexes by heating. Subsequent exposure to pyridoxal 5'-phosphate or pyridoxal markedly inhibited this binding.
Cake, M.H., Di Sorbo, D.M., Litwack, G.
core