Results 51 to 60 of about 11,107 (336)

Grape skin extracts from winemaking by-products as a source of trapping agents for reactive carbonyl species [PDF]

, 2015
BACKGROUND Clinical evidence supports the relationship between carbonyl stress and type II diabetes and its related pathologies. Methylglyoxal (MGO) is the major dicarbonyl compound involved in carbonyl stress.
Anhe, Chen, De la Cruz, Dearlove, Delgado-Andrade, Dorsey, Gordillo, Ho, Jariyapamornkoon, Lo, Matsuda, McDougall, Mesías, Morales, Odani, Peng, Povichit, Rahbar, Reddy, Rice-Evans, Russ, Saraswat, Seeram, Shao, Singh, Singleton, Sri Harsha, Sri Harsha, Sun, Vander Jagt, Wang, Wang, Wu, Yim   +33 more
core   +1 more source

Pyridoxamine alleviates mechanical allodynia by suppressing the spinal receptor for advanced glycation end product-nuclear factor-κB/extracellular signal-regulated kinase signaling pathway in diabetic rats

Molecular Pain, 2020
Diabetic neuropathic pain is a common complication of diabetes mellitus and requires a substantial amount of societal resources. Pyridoxamine is an inhibitor of advanced glycation and lipoxidation end products.
Xin Zhang, Li Xu, Weiyun Chen, Xuerong Yu, Le Shen, Yuguang Huang   +5 more
semanticscholar   +1 more source

Synthesis of [13C3]-B6 Vitamers Labelled at Three Consecutive Positions Starting from [13C3]-Propionic Acid

Molecules, 2018
[13C3]-labelled vitamers (PN, PL and PM) of the B6 group were prepared starting from [13C3]-propionic acid. [13C3]-PN was synthesized in ten linear steps with an overall yield of 17%.
Thomas Bachmann, Michael Rychlik
doaj   +1 more source

Asymmetric biomimetic transamination of α-keto amides to peptides

Nature Communications, 2021
Asymmetric transamination of α-keto amides could provide an efficient strategy to synthesise peptides, but has not been well developed yet. Here, the authors design chiral pyridoxamine catalyst and realize the asymmetric biomimetic transamination of α ...
Weiqi Cai, Xuelong Qiao, Hao Zhang, Bo Li, Jianhua Guo, Liangliang Zhang, Wen-Wen Chen, Baoguo Zhao   +7 more
doaj   +1 more source

Cis-[Cr(C2O4)(pm)(OH2)2]+ Coordination Ion as a Specific Sensing Ion for H2O2 Detection in HT22 Cells

Molecules, 2014
The purpose of this study was to examine the application of the coordinated cis-[Cr(C2O4)(pm)(OH)2]+ cation where pm denotes pyridoxamine, as a specific sensing ion for the detection of hydrogen peroxide (H2O2).
Dagmara Jacewicz, Kamila Siedlecka-Kroplewska, Joanna Pranczk, Dariusz Wyrzykowski, Michał Woźniak, Lech Chmurzyński   +5 more
doaj   +1 more source

Harnessing Photoenzymatic Systems for Intermolecular C–H Fluorination

Angewandte Chemie, EarlyView.
Despite the remarkable versatility of enzymes for catalyzing complex organic transformations under mild aqueous conditions, no biocatalytic system has been reported for intermolecular C–H fluorination. A radical photoenzymatic approach is introduced that leverages a designed de novo protein scaffold with an unnatural amino acid to achieve precise ...
Yu Zhou, Danielle Lawson, Zihan Zhang, Yunling Deng, Hejun Deng, Connor J. O'Dea, Zachariah A. Page, Yi Lu   +7 more
wiley   +2 more sources

Pyridoxamine reduces inflammatory and microcirculatory abnormalities in metabolic dysfunction-associated steatohepatitis and modulates key factors in the hepatic AGE/ALE signaling pathway

Frontiers in Physiology
Metabolic dysfunction-associated steatohepatitis (MASH) is an increasing public health concern for which new therapies are urgently needed. As growing evidence suggests that the advanced glycation/lipoxidation end products (AGE/ALE) pathway contribute to
Raquel Rangel Silvares, Beatriz Peres de Araujo, Evelyn Nunes Goulart Da Silva Pereira, Karine Lino Rodrigues, Juliana Magalhães Chaves Barbosa, Juliana Florencio da Silva, Vivian Vieira Dias da Silva, Marjo Van de aarenburg, Jean Scheijen, Kristiaan Wouters, Casper Schalkwijk, Anissa Daliry   +11 more
doaj   +1 more source

Integrating gene and protein expression data with genome-scale metabolic networks to infer functional pathways [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund. Copyright @ 2013 Pey et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://
Beasley, JE, Pey, J, Planes, FJ, Rubio, A, Valgepea, K   +4 more
core   +1 more source

Advanced Glycation End Product Interventions Reduce Diabetes-Accelerated Atherosclerosis [PDF]

, 2004
Advanced glycation end product (AGE) formation may contribute to the progression of atherosclerosis, particularly in diabetes. The present study explored atherosclerosis in streptozotocin-induced diabetic apolipoprotein E–deficient (apoE / ) mice that ...
Elizabeth K. Deemer, Josephine M. Forbes, Karin A. J, Louis Teo Loon Yee, Mark E. Cooper, Markus Lassila, Merlin C. Thomas, Riccardo C, Susan M. Thorpe, Terri J. Allen, Vicki Thallas, Wendy C. Burns   +11 more
core   +1 more source

The intestine plays a substantial role in human vitamin B6 metabolism: a Caco-2 cell model. [PDF]

PLoS ONE, 2013
BACKGROUND: Vitamin B6 is present in various forms (vitamers) in the diet that need to be metabolized to pyridoxal phosphate (PLP), the active cofactor form of vitamin B6.
Monique Albersen, Marjolein Bosma, Nine V V A M Knoers, Berna H B de Ruiter, Eugène F Diekman, Jessica de Ruijter, Wouter F Visser, Tom J de Koning, Nanda M Verhoeven-Duif   +8 more
doaj   +1 more source