Pyridoxic Acid as Endogenous Biomarker of Renal Organic Anion Transporter Activity: Population Variability and Mechanistic Modeling to Predict Drug–Drug Interactions [PDF]
CPT: Pharmacometrics & Systems PharmacologyPyridoxic acid (PDA) was suggested as a potential endogenous biomarker to assess in vivo renal organic anion transporter (OAT) 1 and 3 activity. Here, we first investigated the population variability in the plasma baseline levels of PDA using data from ...
Aarzoo Thakur +3 more
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Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2021 Renal clearance of many drugs is mediated by renal organic anion transporters OAT1/3 and inhibition of these transporters may lead to drug‐drug interactions (DDIs).
Amais Ahmad +6 more
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4-Pyridoxic Acid/Pyridoxine Ratio in Patients with Type 2 Diabetes is Related to Global Cardiovascular Risk Scores [PDF]
Diagnostics, 2019 Background: Vascular diseases are multifactorial and several risk factors may have synergetic effect on the global vascular risk. Among patients with diabetes, we investigated whether vitamin B6 species differ according to global cardiovascular risk ...
Rima Obeid +2 more
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A one-step NIST traceable HPLC method for quantitation of vitamin B6 and 4-pyridoxic acid in human plasma [PDF]
Practical Laboratory Medicine, 2020 Objectives: Vitamin B6 deficiency is associated with a wide spectrum of clinical syndromes. While vitamin B6 status is primarily assessed by measuring the biologically active form of the vitamin, pyridoxal 5-phosphate (PLP), concurrent measurement of the
Xiaochun Zhang +2 more
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4-Pyridoxic Acid in the Spent Dialysate: Contribution to Fluorescence and Optical Monitoring. [PDF]
PLoS ONE, 2016 In this work we estimated the contribution of the fluorescence of 4-pyridoxic acid (4-PA) to the total fluorescence of spent dialysate with the aim of evaluating the on-line monitoring of removal of this vitamin B-6 metabolite from the blood of patients ...
Sigrid Kalle +5 more
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A Microprocedure for the Determination of 4-Pyridoxic Acid in Urine [PDF]
Clinical Chemistry, 1964 Abstract A microprocedure for the estimation of urinary 4-pyridoxic acid which is apparently specific, yet simple enough for routine clinical use, has been adapted from the Fujita et al. (16-17) and Reddy et al. (22) procedures. Average values for urinary 4-pyridoxic acid for 7 women ranged from 3.8 to 6.9 µM/24 hr. by this method. These
Muriel J. Woodring +2 more
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Elevated plasma 4-pyridoxic acid in renal insufficiency [PDF]
The American Journal of Clinical Nutrition, 2002 Renal insufficiency is associated with altered vitamin B-6 metabolism. We have observed high concentrations of 4-pyridoxic acid, the major catabolite of vitamin B-6 metabolism, in plasma during renal insufficiency.The objective was to evaluate the renal handling of 4-pyridoxic acid and the effects of renal dysfunction on vitamin B-6 metabolism.We ...
Michael P. Whyte +14 more
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Luminescence spectroscopy of pyridoxic acid and pyridoxic acid bound to proteins [PDF]
European Journal of Biochemistry, 1994 Luminescence techniques, i.e. fluorescence and phosphorescence, have been employed to study pyridoxic acid bound to proteins through a stable amide linkage. Proteins tagged with 4‐pyridoxic acid display the following fluorescence properties: (a) emission and excitation spectra centered at around 430 and 320 nm, respectively; (b) fluorescence quantum ...
Jorge E. Churchich +2 more
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High-throughput untargeted metabolomic profiling of urinary biomarkers in acute myocarditis patients: a cross-sectional study [PDF]
Scientific ReportsAcute myocarditis, characterized by inflammatory myocardial injury, significantly risks heart failure and sudden death. Despite its severity, specific biomarkers are lacking.
Cui-mei Zhao +5 more
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Milk metabolome reveals pyrimidine and its degradation products as the discriminant markers of different corn silage-based nutritional strategies [PDF]
Journal of Dairy Science, 2022 : The purpose of this study was to evaluate the effect of 6 different feeding systems (based on corn silage as the main ingredient) on the chemical composition of milk and to highlight the potential of untargeted metabolomics to find discriminant marker ...
G. Rocchetti +5 more
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