Pyridoxic Acid as Endogenous Biomarker of Renal Organic Anion Transporter Activity: Population Variability and Mechanistic Modeling to Predict Drug–Drug Interactions [PDF]
CPT: Pharmacometrics & Systems PharmacologyPyridoxic acid (PDA) was suggested as a potential endogenous biomarker to assess in vivo renal organic anion transporter (OAT) 1 and 3 activity. Here, we first investigated the population variability in the plasma baseline levels of PDA using data from ...
Aarzoo Thakur +3 more
doaj +6 more sources
Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2021 Renal clearance of many drugs is mediated by renal organic anion transporters OAT1/3 and inhibition of these transporters may lead to drug‐drug interactions (DDIs).
Amais Ahmad +6 more
doaj +5 more sources
4-Pyridoxic Acid/Pyridoxine Ratio in Patients with Type 2 Diabetes is Related to Global Cardiovascular Risk Scores [PDF]
Diagnostics, 2019 Background: Vascular diseases are multifactorial and several risk factors may have synergetic effect on the global vascular risk. Among patients with diabetes, we investigated whether vitamin B6 species differ according to global cardiovascular risk ...
Rima Obeid +2 more
doaj +5 more sources
A one-step NIST traceable HPLC method for quantitation of vitamin B6 and 4-pyridoxic acid in human plasma [PDF]
Practical Laboratory Medicine, 2020 Objectives: Vitamin B6 deficiency is associated with a wide spectrum of clinical syndromes. While vitamin B6 status is primarily assessed by measuring the biologically active form of the vitamin, pyridoxal 5-phosphate (PLP), concurrent measurement of the
Xiaochun Zhang +2 more
doaj +4 more sources
4-Pyridoxic Acid in the Spent Dialysate: Contribution to Fluorescence and Optical Monitoring. [PDF]
PLoS ONE, 2016 In this work we estimated the contribution of the fluorescence of 4-pyridoxic acid (4-PA) to the total fluorescence of spent dialysate with the aim of evaluating the on-line monitoring of removal of this vitamin B-6 metabolite from the blood of patients ...
Sigrid Kalle +5 more
doaj +5 more sources
Establishment of age-stratified serum vitamin B6 pyridoxal and pyridoxic acid reference intervals among children aged 1–16 years in Henan, china [PDF]
Frontiers in NutritionBackground/ObjectiveThe development of population-specific reference intervals (RIs) for serum vitamin B6 (B6) in Chinese pediatric populations has not been established.
Yusheng Luan +5 more
doaj +5 more sources
Serum B6 vitamers (pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid) and pancreatic cancer risk: two nested case-control studies in Asian populations. [PDF]
Cancer Causes Control, 2016 Vitamin B6 is an important enzymatic cofactor in pathways relevant for the development of pancreatic cancer. In order to evaluate vitamin B6 as a preventive factor for pancreatic cancer, a biomarker approach is needed to overcome the limitations inherent in self-reported dietary information.To determine whether levels of serum B6 vitamers, including ...
Huang JY +8 more
europepmc +6 more sources
Serum Pyridoxal 5'-Phosphate and Pyridoxic Acid Ratio Index with Prognosis of Colorectal Cancer: A Prospective Cohort Study. [PDF]
NutrientsBackground: Studies on the association between serum vitamin B6 status and colorectal cancer prognosis are limited and have yielded inconsistent results. This study investigated the association of pyridoxal 5′-phosphate (PLP) and pyridoxic acid ratio (PAr) index with colorectal cancer survival.
Li X +6 more
europepmc +5 more sources
Urinary 4-pyridoxic acid as a non-invasive biomarker for evaluating osteoarthritis severity: findings from the ROAD study. [PDF]
Aging Clin Exp ResThe early detection of osteoarthritis (OA) requires reliable biomarkers; however, reports identifying such biomarkers remain limited. This study aimed to evaluate the potential of urinary 4-pyridoxic acid (4PA) as a biomarker for the severity of knee ...
Yoshimura N +7 more
europepmc +4 more sources
Journal of Chromatography B, 2022 Vitamin B6 and its metabolites play a crucial role in the development and interaction of brain metabolism. Following diagnostic improvements additional inherited disorders in vitamin B6 metabolism have been identified, most of them leading to a severe epileptic disorder accompanied by progressive neurological deficits including intellectual disability ...
Julia Rossmann +6 more
semanticscholar +5 more sources