Pyridoxine-Dependent Epilepsy and Antiquitin Deficiency Resulting in Neonatal-Onset Refractory Seizures [PDF]
Brain Sciences, 2021 Pyridoxine-dependent epilepsy (PDE) is an autosomal recessive neurometabolic disorder due to a deficiency of α-aminoadipic semialdehyde dehydrogenase (mutation in ALDH7A1 gene), more commonly known as antiquitin (ATQ).
Konrad Kaminiów +3 more
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Pyridoxine‐dependent epilepsy: Current perspectives and questions for future research [PDF]
Annals of the Child Neurology Society, 2023 Pyridoxine‐dependent epilepsy (PDE) was historically defined by a dramatic clinical response to a trial of pyridoxine and the re‐emergence of seizures after withdrawal of pyridoxine.
Curtis R. Coughlin II +1 more
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Effects of Pyridoxine Deficiency on Hippocampal Function and Its Possible Association with V-Type Proton ATPase Subunit B2 and Heat Shock Cognate Protein 70 [PDF]
Cells, 2020 Pyridoxine, one of the vitamin B6 vitamers, plays a crucial role in amino acid metabolism and synthesis of monoamines as a cofactor. In the present study, we observed the effects of pyridoxine deficiency on novel object recognition memory.
Hyo Young Jung +9 more
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Scientific Opinion on the safety and efficacy of vitamin B6 (pyridoxine hydrochloride) as a feed additive for all animal species [PDF]
EFSA Journal, 2011 Pyridoxine hydrochloride is a form of vitamin B6, an essential micronutrient. Oral administration routes of pyridoxine hydrochloride via feed or water are considered as bioequivalent.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
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Moderate pyridoxal phosphate deficiency enhances neuronal excitability and promotes calcium dysregulation [PDF]
Frontiers in NeuroscienceObjectivePyridoxal 5′-phosphate (PLP), the active form of pyridoxine (vitamin B6), is essential for converting glutamate into the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Severe consequences of PLP deficiency due to genetic defects are
Valerie Girgis +5 more
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Combination Therapy with Pyridoxine and Arginine Supplementations along with a Lysine-Restricted Diet in Individuals with Pyridoxine-Dependent Epilepsy: A Comprehensive Systematic Review [PDF]
Current Developments in NutritionBackground: Pyridoxine-dependent epilepsy (PDE) is identified as a rare neurometabolic disease marked by biallelic pathogenic mutations of the ALDH7A1 gene.
Ali Jafari +5 more
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Low-Dose Pyridoxine Masks Pyridoxine-Dependent Seizures
Pediatric Neurology Briefs, 2001 A 4-month-old male infant with pyridoxine dependency and seizures from birth was controlled with extremely low-dose pyridoxine (0.5 mg/day) given as a vitamin supplement, in a report from Joana de Gusmao Children’s Hospital, Florianopolis, Brazil.
J Gordon Millichap
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A Multifunctional Oxovanadium(V) Schiff Base Complex: Integrated Pyridoxine Sensing and Anticancer and Antimicrobial Activities. [PDF]
Bioinorg Chem ApplKohanfekr T, Hosseini HA.
europepmc +3 more sources
Integrative Cancer Therapies, 2022 Purpose: Pegylated liposomal doxorubicin (PLD) is highly effective for treating multiple myeloma (MM). Hand-foot syndrome (HFS) is a dose-limiting adverse event of PLD that may reduce a patient’s quality of life or prevent certain patients from receiving
Li Xiaozhe MD +6 more
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Animal Nutrition, 2021 This study was conducted to evaluate the effect of pyridoxine on the development of hair follicles in Rex rabbits and the underlying molecular mechanism.
Gongyan Liu +9 more
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