Results 1 to 10 of about 59,025 (322)

Moderate pyridoxal phosphate deficiency enhances neuronal excitability and promotes calcium dysregulation [PDF]

Frontiers in Neuroscience
ObjectivePyridoxal 5′-phosphate (PLP), the active form of pyridoxine (vitamin B6), is essential for converting glutamate into the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Severe consequences of PLP deficiency due to genetic defects are
Valerie Girgis, Ashlyn Tharington, Jadyn Trivett, Sylvia Fitting, Rick B. Meeker, Clio Rubinos   +5 more
doaj   +2 more sources

Combination Therapy with Pyridoxine and Arginine Supplementations along with a Lysine-Restricted Diet in Individuals with Pyridoxine-Dependent Epilepsy: A Comprehensive Systematic Review [PDF]

Current Developments in Nutrition
Background: Pyridoxine-dependent epilepsy (PDE) is identified as a rare neurometabolic disease marked by biallelic pathogenic mutations of the ALDH7A1 gene.
Ali Jafari, Mohammad Mehdi Abbasi, Hamid Abbasi, Sama Rahnemayan, Farnush Bakhshimoghaddam, Saeid Doaei   +5 more
doaj   +2 more sources

Pyridoxine Is Effective for Preventing Hand-Foot Syndrome Induced by Pegylated Liposomal Doxorubicin for Multiple Myeloma: The Results of a Randomized Study

Integrative Cancer Therapies, 2022
Purpose: Pegylated liposomal doxorubicin (PLD) is highly effective for treating multiple myeloma (MM). Hand-foot syndrome (HFS) is a dose-limiting adverse event of PLD that may reduce a patient’s quality of life or prevent certain patients from receiving
Li Xiaozhe MD, Chen Meilan MD, Huang Beihui MD, Liu Junru MD, Gu Jingli MD, Kuang Lifen MD, Li Juan MD   +6 more
doaj   +1 more source

Pyridoxine regulates hair follicle development via the PI3K/Akt, Wnt and Notch signalling pathways in rex rabbits

Animal Nutrition, 2021
This study was conducted to evaluate the effect of pyridoxine on the development of hair follicles in Rex rabbits and the underlying molecular mechanism.
Gongyan Liu, Guangmin Cheng, Yongcui Zhang, Shuxia Gao, Haitao Sun, Liya Bai, Shu Li, Yanli Zhu, Chunyang Wang, Fuchang Li   +9 more
doaj   +1 more source

Impact of vitamin B6 deficiency on the severity of diabetic peripheral neuropathy – A cross sectional study

Saudi Pharmaceutical Journal, 2023
Background: Diabetic Peripheral Neuropathy is one of the most important and significantly prevalent microvascular complications of Diabetes Mellitus. Pyridoxine is a key nutrient for protecting nerve health. The objective of this research is to study the
Moteb Khobrani, Geetha Kandasamy, Rajalakshimi Vasudevan, AbdulAziz Alhossan, Ranadheer Chowdary Puvvada, Praveen Devanandan, Rajeshri Dhurke, Manusri Naredla   +7 more
doaj   +1 more source

The Impacts of Graded Doses of Pyridoxine on the Biomarkers, Aspartate Aminotransferase, lactate Dehydrogenase and Total Antioxidant Capacity in Doxorubicin-Induced Cardiotoxicity in Female Rats

Iraqi Journal of Pharmaceutical Sciences, 2017
:        The aim of the current study was to investigate the possible protective effect of graded doses (5, 10, and 15mg/kg) of pyridoxine hydrochloride intraperitoneally injected against (15mg/kg) doxorubicin-induced cardiotoxicity in female rats ...
Doaa Kadhim Abdul Ridha, Nada Naji Al-Shawi   +1 more
doaj   +3 more sources

Pyridoxine deficiency modulates benzene inhalation-induced hematotoxicity associated with hepatic CYP2E1 activity in B6C3F1 mice

Toxicology Reports, 2021
Pyridoxine is a co-factor in many enzymatic reactions and impacts of deficiency have been observed in affected populations. A possible modifying effect of pyridoxine deficiency on benzene toxicity was assessed in male B6C3F1 mice fed either a pyridoxine ...
Chanthana Tangjarukij, Daam Settachan, Judith T. Zelikoff, Panida Navasumrit, Mathuros Ruchirawat   +4 more
doaj   +1 more source

Beta-nerve growth factor gene therapy alleviates pyridoxine-induced neuropathic damage by increasing doublecortin and tyrosine kinase A in the dorsal root ganglion

Neural Regeneration Research, 2020
Beta-nerve growth factor (β-NGF) is known to be a major leading cause of neuronal plasticity. To identify the possible action mechanisms of β-NGF gene therapy for sciatic nerve recovery, experimental dogs were randomly divided into control, pyridoxine ...
Hyun-Kee Cho, Woosuk Kim, Kwon-Young Lee, Jin-Ok Ahn, Jung Hoon Choi, In Koo Hwang, Jin-Young Chung   +6 more
doaj   +1 more source

Analysis of clinical features and genetic variants in Chinese children with pyridoxine-dependent epilepsy: a case series study. [PDF]

Front Neurol
Yu X, Zhang X, Qiu S, Yang L, Li X, Shi D.   +5 more
europepmc   +3 more sources

8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information. [PDF]

PLoS ONE, 2017
OBJECTIVESWe report information about an unpublished 1970s study ("8-way" Bendectin Study) that aimed to evaluate the relative therapeutic efficacy of doxylamine, pyridoxine, and dicyclomine in the management of nausea and vomiting during pregnancy.
Rujun Zhang, Navindra Persaud
doaj   +1 more source