Results 1 to 10 of about 28,846 (248)

Moderate pyridoxal phosphate deficiency enhances neuronal excitability and promotes calcium dysregulation [PDF]

Frontiers in Neuroscience
ObjectivePyridoxal 5′-phosphate (PLP), the active form of pyridoxine (vitamin B6), is essential for converting glutamate into the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Severe consequences of PLP deficiency due to genetic defects are
Valerie Girgis, Ashlyn Tharington, Jadyn Trivett, Sylvia Fitting, Rick B. Meeker, Clio Rubinos   +5 more
doaj   +2 more sources

Dietary Pyridoxine Requirements of Coho Salmon (Oncorhynchus kisutch) Post-Smolts [PDF]

Aquaculture Nutrition
A 10-week feeding trial was conducted to investigate the dietary pyridoxine requirements of coho salmon (Oncorhynchus kisutch) post-smolts with an initial mean body weight of 180.22 ± 0.41 g. Seven diets were prepared with gradient pyridoxine levels of 0.
Hairui Yu, Xinyue Zhang, Ziyi Yuan, Leyong Yu, Youzhi Zhao, Lingyao Li   +5 more
doaj   +2 more sources

Case report: Clinical and genetic characterization of a novel ALDH7A1 variant causing pyridoxine-dependent epilepsy, developmental delay, and intellectual disability in two siblings [PDF]

Frontiers in Psychiatry
BackgroundPathogenic variants in ALDH7A1 are associated with pyridoxine-dependent epilepsy (PDE), a rare autosomal recessive disorder characterized by epileptic seizures, unresponsiveness to standard antiseizure medications (ASM), and a response only to ...
Mustafa A. Salih, Albandary AlBakheet, Rawan Almass, Ahlam A. A. Hamed, Ali AlOdaib, Namik Kaya   +5 more
doaj   +2 more sources

Pyridoxine-dependent epilepsy caused by an ALDH7A1 mutation in an infant girl: the first case report in Syria [PDF]

BMC Neurology
Background Pyridoxine-dependent epilepsy is primarily characterized by early-onset refractory seizures. This condition can be caused by alpha-aminoadipic semialdehyde dehydrogenase deficiency due to a mutation in the ALDH7A1 gene, leading to the ...
Rida Jaber, Hadi Salame, Mostafa Zeindeen, Ali Jawad, Hassan Fawaz, Diana Alasmar   +5 more
doaj   +2 more sources

Pyridoxine-dependent and pyridoxine-responsive seizures [PDF]

Developmental Medicine and Child Neurology, 2001
Pyridoxine dependency was one of the first genetically mediated seizure disorders to be recognized. However, the biochemical abnormality and gene locus are still unknown. Knowledge about the condition has come from case reports and small clinical series. However, new features are still being recognized both clinically, as well as more predictably, from
M Huyton, D Hindley
openaire   +5 more sources

Pyridoxine Is Effective for Preventing Hand-Foot Syndrome Induced by Pegylated Liposomal Doxorubicin for Multiple Myeloma: The Results of a Randomized Study

Integrative Cancer Therapies, 2022
Purpose: Pegylated liposomal doxorubicin (PLD) is highly effective for treating multiple myeloma (MM). Hand-foot syndrome (HFS) is a dose-limiting adverse event of PLD that may reduce a patient’s quality of life or prevent certain patients from receiving
Li Xiaozhe MD, Chen Meilan MD, Huang Beihui MD, Liu Junru MD, Gu Jingli MD, Kuang Lifen MD, Li Juan MD   +6 more
doaj   +1 more source

The Impacts of Graded Doses of Pyridoxine on the Biomarkers, Aspartate Aminotransferase, lactate Dehydrogenase and Total Antioxidant Capacity in Doxorubicin-Induced Cardiotoxicity in Female Rats

Iraqi Journal of Pharmaceutical Sciences, 2017
:        The aim of the current study was to investigate the possible protective effect of graded doses (5, 10, and 15mg/kg) of pyridoxine hydrochloride intraperitoneally injected against (15mg/kg) doxorubicin-induced cardiotoxicity in female rats ...
Doaa Kadhim Abdul Ridha, Nada Naji Al-Shawi   +1 more
doaj   +3 more sources

Beta-nerve growth factor gene therapy alleviates pyridoxine-induced neuropathic damage by increasing doublecortin and tyrosine kinase A in the dorsal root ganglion

Neural Regeneration Research, 2020
Beta-nerve growth factor (β-NGF) is known to be a major leading cause of neuronal plasticity. To identify the possible action mechanisms of β-NGF gene therapy for sciatic nerve recovery, experimental dogs were randomly divided into control, pyridoxine ...
Hyun-Kee Cho, Woosuk Kim, Kwon-Young Lee, Jin-Ok Ahn, Jung Hoon Choi, In Koo Hwang, Jin-Young Chung   +6 more
doaj   +1 more source

8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information. [PDF]

PLoS ONE, 2017
OBJECTIVESWe report information about an unpublished 1970s study ("8-way" Bendectin Study) that aimed to evaluate the relative therapeutic efficacy of doxylamine, pyridoxine, and dicyclomine in the management of nausea and vomiting during pregnancy.
Rujun Zhang, Navindra Persaud
doaj   +1 more source

Pyridoxine‐responsive KCNQ2 epileptic encephalopathy: Additional cases and literature review

Molecular Genetics & Genomic Medicine, 2022
Background Typical patients with KCNQ2 (OMIM# 602235) epileptic encephalopathy present early neonatal‐onset intractable seizures with a burst suppression EEG pattern and severe developmental delay or regression, and those patients always fail first‐line ...
Jun Chen, Qiuji Tao, Lijuan Fan, Yajun Shen, Jinfeng Liu, Huan Luo, Zuozhen Yang, Mengmeng Liang, Jing Gan   +8 more
doaj   +1 more source