Results 11 to 20 of about 66,485 (345)

Vitamin B-6-Induced Neuropathy: Exploring the Mechanisms of Pyridoxine Toxicity

Advances in Nutrition, 2021
Vitamin B-6 in the form of pyridoxine (PN) is commonly used by the general population. The use of PN-containing supplements has gained lots of attention over the past years as they have been related to the development of peripheral neuropathy.
Felix Hadtstein, M. Vrolijk
semanticscholar   +1 more source

Pyridoxine Is Effective for Preventing Hand-Foot Syndrome Induced by Pegylated Liposomal Doxorubicin for Multiple Myeloma: The Results of a Randomized Study

Integrative Cancer Therapies, 2022
Purpose: Pegylated liposomal doxorubicin (PLD) is highly effective for treating multiple myeloma (MM). Hand-foot syndrome (HFS) is a dose-limiting adverse event of PLD that may reduce a patient’s quality of life or prevent certain patients from receiving
Li Xiaozhe MD, Chen Meilan MD, Huang Beihui MD, Liu Junru MD, Gu Jingli MD, Kuang Lifen MD, Li Juan MD   +6 more
doaj   +1 more source

Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection

Nature Communications, 2020
Oxidative stress is a major pathogenic mechanism in Parkinson’s disease (PD). As an important cellular antioxidant, glutathione (GSH) balances the production and incorporation of free radicals to protect neurons from oxidative damage.
Y. Wei, Ming Lu, M. Mei, Hao Wang, Zhitao Han, Miaomiao Chen, H. Yao, Nanshan Song, Xiaojing Ding, Jian-hua Ding, Ming Xiao, G. Hu   +11 more
semanticscholar   +1 more source

Genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy (ALDH7A1 deficiency) [PDF]

, 2010
Pyridoxine-dependent epilepsy was recently shown to be due to mutations in the ALDH7A1 gene, which encodes antiquitin, an enzyme that catalyses the nicotinamide adenine dinucleotide-dependent dehydrogenation of L-{alpha}-aminoadipic semialdehyde/L-{Delta}
Adam, Basura, Baxter, Bennett, Bernhard Schmitt, Cheryl Hemingway, Clayton, Clayton, Cornelis Jakobs, Eduard A. Struys, Emma J. Footitt, Ernst Christensen, François Feillet, Gallagher, Gospe, Goto, Hoffmann, Hunt, Janet Rennie, Kaczorowska, Kanno, Karin Tuschl, Kevin A. Mills, Kim, Kluger, Kurlemann, Lauras, M. Imelda Hughes, Mike G. Pike, Mills, Nabbout, Neil Marlow, Olivier Dulac, Ormazabal, Pascale De Lonlay, Peduto, Perozich, Peter Baxter, Peter T. Clayton, Philippa B. Mills, Plecko, Plecko, Rankin, Rima Nabbout, Salomons, Sameer M. Zuberi, Sarah Aylett, Sophia Varadkar, Striano, Tang, William J. Craigen   +50 more
core   +7 more sources

Consensus guidelines for the diagnosis and management of pyridoxine‐dependent epilepsy due to α‐aminoadipic semialdehyde dehydrogenase deficiency

Journal of Inherited Metabolic Disease, 2020
Pyridoxine‐dependent epilepsy (PDE‐ALDH7A1) is an autosomal recessive condition due to a deficiency of α‐aminoadipic semialdehyde dehydrogenase, which is a key enzyme in lysine oxidation.
C. Coughlin, L. Tseng, J. Abdenur, C. Ashmore, F. Boemer, L. Bok, M. Boyer, D. Buhas, P. Clayton, A. Das, Hanka Dekker, A. Evangeliou, F. Feillet, E. Footitt, S. Gospe, H. Hartmann, Majdi Kara, E. Kristensen, J. Lee, R. Lilje, N. Longo, R. Lunsing, P. Mills, M. Papadopoulou, P. Pearl, F. Piazzon, B. Plecko, A. Saini, S. Santra, D. Sjarif, S. Stockler-Ipsiroglu, P. Striano, J. V. Van Hove, N. Verhoeven-Duif, F. Wijburg, S. Zuberi, C. V. van Karnebeek   +36 more
semanticscholar   +1 more source

The Impacts of Graded Doses of Pyridoxine on the Biomarkers, Aspartate Aminotransferase, lactate Dehydrogenase and Total Antioxidant Capacity in Doxorubicin-Induced Cardiotoxicity in Female Rats

Iraqi Journal of Pharmaceutical Sciences, 2017
:        The aim of the current study was to investigate the possible protective effect of graded doses (5, 10, and 15mg/kg) of pyridoxine hydrochloride intraperitoneally injected against (15mg/kg) doxorubicin-induced cardiotoxicity in female rats ...
Doaa Kadhim Abdul Ridha, Nada Naji Al-Shawi   +1 more
doaj   +3 more sources

Cystathionine β‐synthase deficiency in the E‐HOD registry‐part I: pyridoxine responsiveness as a determinant of biochemical and clinical phenotype at diagnosis

Journal of Inherited Metabolic Disease, 2020
Cystathionine β‐synthase (CBS) deficiency has a wide clinical spectrum, ranging from neurodevelopmental problems, lens dislocation and marfanoid features in early childhood to adult onset disease with predominantly thromboembolic complications.
V. Kožich, J. Sokolová, A. Morris, M. Pavlíková, F. Gleich, S. Kölker, J. Krijt, C. Dionisi-Vici, M. Baumgartner, H. Blom, M. Huemer   +10 more
semanticscholar   +1 more source

Beta-nerve growth factor gene therapy alleviates pyridoxine-induced neuropathic damage by increasing doublecortin and tyrosine kinase A in the dorsal root ganglion

Neural Regeneration Research, 2020
Beta-nerve growth factor (β-NGF) is known to be a major leading cause of neuronal plasticity. To identify the possible action mechanisms of β-NGF gene therapy for sciatic nerve recovery, experimental dogs were randomly divided into control, pyridoxine ...
Hyun-Kee Cho, Woosuk Kim, Kwon-Young Lee, Jin-Ok Ahn, Jung Hoon Choi, In Koo Hwang, Jin-Young Chung   +6 more
doaj   +1 more source

pH-dependent pyridoxine transport by SLC19A2 and SLC19A3: Implications for absorption in acidic microclimates

Journal of Biological Chemistry, 2020
SLC19A2 and SLC19A3, also known as thiamine transporters (THTR) 1 and 2, respectively, transport the positively charged thiamine (vitamin B1) into cells to enable its efficient utilization.
Takahiro Yamashiro, Tomoya Yasujima, H. Said, H. Yuasa   +3 more
semanticscholar   +1 more source

B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin

CNS Neuroscience & Therapeutics, 2019
Neurotropic B vitamins play crucial roles as coenzymes and beyond in the nervous system. Particularly vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) contribute essentially to the maintenance of a healthy nervous system.
C. Calderón-Ospina, M. O. Nava-Mesa
semanticscholar   +1 more source