Results 21 to 30 of about 70,295 (294)

Beta-nerve growth factor gene therapy alleviates pyridoxine-induced neuropathic damage by increasing doublecortin and tyrosine kinase A in the dorsal root ganglion

Neural Regeneration Research, 2020
Beta-nerve growth factor (β-NGF) is known to be a major leading cause of neuronal plasticity. To identify the possible action mechanisms of β-NGF gene therapy for sciatic nerve recovery, experimental dogs were randomly divided into control, pyridoxine ...
Hyun-Kee Cho, Woosuk Kim, Kwon-Young Lee, Jin-Ok Ahn, Jung Hoon Choi, In Koo Hwang, Jin-Young Chung   +6 more
doaj   +1 more source

Consensus guidelines for the diagnosis and management of pyridoxine‐dependent epilepsy due to α‐aminoadipic semialdehyde dehydrogenase deficiency

Journal of Inherited Metabolic Disease, 2020
Pyridoxine‐dependent epilepsy (PDE‐ALDH7A1) is an autosomal recessive condition due to a deficiency of α‐aminoadipic semialdehyde dehydrogenase, which is a key enzyme in lysine oxidation.
C. Coughlin, L. Tseng, J. Abdenur, C. Ashmore, F. Boemer, L. Bok, M. Boyer, D. Buhas, P. Clayton, A. Das, Hanka Dekker, A. Evangeliou, F. Feillet, E. Footitt, S. Gospe, H. Hartmann, Majdi Kara, E. Kristensen, J. Lee, R. Lilje, N. Longo, R. Lunsing, P. Mills, M. Papadopoulou, P. Pearl, F. Piazzon, B. Plecko, A. Saini, S. Santra, D. Sjarif, S. Stockler-Ipsiroglu, P. Striano, J. V. Van Hove, N. Verhoeven-Duif, F. Wijburg, S. Zuberi, C. V. van Karnebeek   +36 more
semanticscholar   +1 more source

Cystathionine β‐synthase deficiency in the E‐HOD registry‐part I: pyridoxine responsiveness as a determinant of biochemical and clinical phenotype at diagnosis

Journal of Inherited Metabolic Disease, 2020
Cystathionine β‐synthase (CBS) deficiency has a wide clinical spectrum, ranging from neurodevelopmental problems, lens dislocation and marfanoid features in early childhood to adult onset disease with predominantly thromboembolic complications.
V. Kožich, J. Sokolová, A. Morris, M. Pavlíková, F. Gleich, S. Kölker, J. Krijt, C. Dionisi-Vici, M. Baumgartner, H. Blom, M. Huemer   +10 more
semanticscholar   +1 more source

Pyridoxine‐responsive KCNQ2 epileptic encephalopathy: Additional cases and literature review

Molecular Genetics & Genomic Medicine, 2022
Background Typical patients with KCNQ2 (OMIM# 602235) epileptic encephalopathy present early neonatal‐onset intractable seizures with a burst suppression EEG pattern and severe developmental delay or regression, and those patients always fail first‐line ...
Jun Chen, Qiuji Tao, Lijuan Fan, Yajun Shen, Jinfeng Liu, Huan Luo, Zuozhen Yang, Mengmeng Liang, Jing Gan   +8 more
doaj   +1 more source

pH-dependent pyridoxine transport by SLC19A2 and SLC19A3: Implications for absorption in acidic microclimates

Journal of Biological Chemistry, 2020
SLC19A2 and SLC19A3, also known as thiamine transporters (THTR) 1 and 2, respectively, transport the positively charged thiamine (vitamin B1) into cells to enable its efficient utilization.
Takahiro Yamashiro, Tomoya Yasujima, H. Said, H. Yuasa   +3 more
semanticscholar   +1 more source

Pyridoxine: The ‘Ba.Six’ of use in Nausea and Vomiting of Pregnancy [PDF]

Journal of Clinical and Diagnostic Research, 2019
Over the centuries, the dietary and biochemical essentiality of pyridoxine in the humans has been well established. Apart from various physiological functions, pyridoxine is therapeutically important in Nausea and Vomiting of Pregnancy (NVP).
Abbas Hassan, Arun Kumar Dubey, Malpe Surekha Bhat   +2 more
doaj   +1 more source

Genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy (ALDH7A1 deficiency) [PDF]

, 2010
Pyridoxine-dependent epilepsy was recently shown to be due to mutations in the ALDH7A1 gene, which encodes antiquitin, an enzyme that catalyses the nicotinamide adenine dinucleotide-dependent dehydrogenation of L-{alpha}-aminoadipic semialdehyde/L-{Delta}
Adam, Basura, Baxter, Bennett, Bernhard Schmitt, Cheryl Hemingway, Clayton, Clayton, Cornelis Jakobs, Eduard A. Struys, Emma J. Footitt, Ernst Christensen, François Feillet, Gallagher, Gospe, Goto, Hoffmann, Hunt, Janet Rennie, Kaczorowska, Kanno, Karin Tuschl, Kevin A. Mills, Kim, Kluger, Kurlemann, Lauras, M. Imelda Hughes, Mike G. Pike, Mills, Nabbout, Neil Marlow, Olivier Dulac, Ormazabal, Pascale De Lonlay, Peduto, Perozich, Peter Baxter, Peter T. Clayton, Philippa B. Mills, Plecko, Plecko, Rankin, Rima Nabbout, Salomons, Sameer M. Zuberi, Sarah Aylett, Sophia Varadkar, Striano, Tang, William J. Craigen   +50 more
core   +3 more sources

B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin

CNS Neuroscience & Therapeutics, 2019
Neurotropic B vitamins play crucial roles as coenzymes and beyond in the nervous system. Particularly vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) contribute essentially to the maintenance of a healthy nervous system.
C. Calderón-Ospina, M. O. Nava-Mesa
semanticscholar   +1 more source

Effect of pyridoxine treatment of a homocystinuric patient on the urinary excretion of some sulfur-containing amino acids [PDF]

, 1974
The effect of pyridoxine treatment of a homocystinuric patient on the urinary excretion of some sulfur-containing amino acids was studied and the following results were obtained.
Ikegami, T., Kodama, H., Oura, T., Yao, K.   +3 more
core   +1 more source

USE OF PYRIDOXINE TO INCREASE ANTICACNER ACTIVITY OF METHIONINE-GAMMA-LYASE IN MURINE CANCER MODELS

Сибирский онкологический журнал, 2017
We presented results of monotherapy and combination therapy of transplantable murine tumor models using methionine-gamma-lyase (MGL) and pyridoxine hydrochloride. We studied MGL from Clostridium sporogenes and Citrobacter freundii.
D. Zh. Davydov, Е. А. Morozova, М. V. Komarova, N. V. Anufrieva, G. B. Zavilgelsky, I. V. Manukhov, T. V. Demidkina, Е. М. Treshchalina, V. S. Pokrovsky   +8 more
doaj   +1 more source