Results 51 to 60 of about 2,422 (193)

Inonotus obliquus attenuates histamine-induced microvascular inflammation.

open access: yesPLoS ONE, 2019
Cell-to-cell communication is a key element of microvascular blood flow control, including rapidly carrying signals through the vascular endothelium in response to local stimuli.
Sumreen Javed   +8 more
doaj   +1 more source

Mechanisms Underlying the Vasorelaxant Effect Induced by Proanthocyanidin-Rich Fraction From Croton celtidifolius in Rat Small Resistance Arteries

open access: yesJournal of Pharmacological Sciences, 2008
Proanthocyanidins are condensed tannins present in fruits, vegetables, and flowers, consumed in the human diet. These compounds are believed to decrease coronary heart disease.
Silvia DalBó   +6 more
doaj   +1 more source

Indometh acin-antihistamine combination for gastric ulceration control [PDF]

open access: yes, 1980
An anti-inflammatory and analgesic composition containing indomethacin and an H2 histamine receptor antagonist in an amount sufficient to reduce gastric distress caused by the indomethacin was developed.
Brown, P. A., Vernikos, J.
core   +1 more source

Genetic Analysis of Histamine Signaling in Larval Zebrafish Sleep [PDF]

open access: yes, 2017
Pharmacological studies in mammals and zebrafish suggest that histamine plays an important role in promoting arousal. However, genetic studies using rodents with disrupted histamine synthesis or signaling have revealed only subtle or no sleep/wake ...
Chen, Audrey   +3 more
core   +1 more source

The role of GABA-B in sensorigating processing disorders in rat models, an autoradiographic study [PDF]

open access: yes, 2019
INTRODUCTION: The process of sensorimotor gating is a neurological phenomenon referring to the brain’s ability to process and filter out stimuli in order to prevent an overflow of information.
Zhuang, Alex
core  

Decoding Pain: Next‐Generation In Vitro Systems for Mechanistic Insights and Drug Discovery

open access: yesThe FASEB Journal, Volume 39, Issue 16, 31 August 2025.
Developing an in vitro pain model that mimics essential features of the in vivo pain circuit requires careful consideration of multiple components and choices. These include selecting the cellular population for the model, choosing from the origin of nociceptors and other cells that are cultured, deciding between 3D or 2D dimensions, designing the ...
Dara Khosrowshahi   +2 more
wiley   +1 more source

Disruption of histamine/H1R signaling pathway represses cardiac differentiation and maturation of human induced pluripotent stem cells

open access: yesStem Cell Research & Therapy, 2020
Background The efficiency and quality of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are crucial for regenerative medicine, disease modeling, drug screening, and the study of the development events during cardiac specification.
Xiaowei Zhu   +9 more
doaj   +1 more source

MRGPRX2 Mediates Mast Cell‐Induced Endometriosis Pain Through the Sensitization of Sensory Neurons via Histamine/HRH1/TRPV1 Signaling Pathway

open access: yesThe FASEB Journal, Volume 39, Issue 13, 15 July 2025.
Endometriotic cell‐derived HBD‐2 mediated the secretion of histamine from mast cells by binding to MRGPRX2. Histamine sensitized TRPV1 via the activation of HRH1 in pain sensory neurons, thus aggravating hyperalgesia in an endometriosis model. ABSTRACT The studies on how mast cells mediate endometriosis pain are still limited.
Xinqi Mao   +6 more
wiley   +1 more source

The effects of histaminergic agents in the nucleus accumbens of rats in the elevated plus-maze test of anxiety.

open access: yesIranian Journal of Psychiatry, 2010
Objective: The nucleus accumbens (NAc) receive histaminergic neurons from tuberomammillary nuclei. There are reports indicating that central histamine systems are involved in many physiological behavioral processes, including anxiety.
Mohammad-Reza Zarrindast   +2 more
doaj   +2 more sources

Marjoram Relaxes Rat Thoracic Aorta Via a PI3-K/eNOS/cGMP Pathway

open access: yesBiomolecules, 2019
Despite pharmacotherapeutic advances, cardiovascular disease (CVD) remains the primary cause of global mortality. Alternative approaches, such as herbal medicine, continue to be sought to reduce this burden.
Adnan Badran   +7 more
doaj   +1 more source

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