Results 51 to 60 of about 3,638 (238)
Fluids and Barriers of the CNS, 2013 Background Knowledge of the molecular basis and transport function of the human blood–brain barrier (BBB) is important for not only understanding human cerebral physiology, but also development of new central nervous system (CNS)-acting drugs.
Shimomura Keita +6 more
doaj +1 more source
A new house dust mite–driven and mast cell–activated model of asthma in the guinea pig
Clinical &Experimental Allergy, Volume 50, Issue 10, Page 1184-1195, October 2020., 2020 Abstract Background Animal models are extensively used to study underlying mechanisms in asthma. Guinea pigs share anatomical, pharmacological and physiological features with human airways and may enable the development of a pre‐clinical in vivo model that closely resembles asthma. Objectives To develop an asthma model in guinea pigs using the allergen
Patricia Ramos‐Ramírez +8 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 24, Issue 6, Page 3504-3520, March 2020., 2020 Abstract Neutrophil‐platelet interactions are responsible for thrombosis as well as inflammatory responses following acute myocardial infarction (AMI). While histamine has been shown to play a crucial role in many physiological and pathological processes, its effects on neutrophil‐platelet interactions in thromboinflammatory complications of AMI remain
Hui Li +8 more
wiley +1 more source
Histamine, histamine receptors, and neuropathic pain relief
British Journal of Pharmacology, Volume 177, Issue 3, Page 580-599, February 2020., 2020 Histamine, acting via distinct histamine H1, H2, H3, and H4 receptors, regulates various physiological and pathological processes, including pain. In the last two decades, there has been a particular increase in evidence to support the involvement of H3 receptor and H4 receptor in the modulation of neuropathic pain, which remains challenging in terms ...
Ilona Obara +3 more
wiley +1 more source
H(1)-Receptor activation triggers the endogenous nitric oxide signalling system in the rat submandibular gland. [PDF]
, 2002 BACKGROUND: Histamine is released from mast cells by immunologic and non-immunologic stimuli during salivary gland inflammation, regulating salivary secretion. The receptor-secretory mechanism has not been studied in detail.
Borda, Enri +2 more
core +3 more sources
Evaluation of In Vitro Uterotonic Activities of Fruit Extracts of Ficus asperifolia in Rats [PDF]
, 2011 The aim of the present study was to determine the uterotonic activities of Ficus asperifolia and investigate its mechanism. The effects of aqueous and methanol extracts of the dried fruits of F.
Alango Nkeng-Efouet, Pepin +4 more
core +3 more sources
Mexican Journal of Medical Research ICSA, 2013 Dysmenorrhea is one of the cyclical processes in chronic pelvic pain. Dysmenorrhea in women causes a high psychosocial and economic impact. For this reason, we conducted a study to assess the prevalence, impact and use of drugs for the treatment of ...
Héctor A. Ponce-Monter +8 more
doaj +1 more source
Histamine activates an intracellular Ca2+ signal in normal human lung fibroblast WI-38 cells
Frontiers in Cell and Developmental Biology, 2022 Histamine is an inflammatory mediator that can be released from mast cells to induce airway remodeling and cause persistent airflow limitation in asthma.
Roberto Berra-Romani +11 more
doaj +1 more source
Vasopeptidase-activated latent ligands of the histamine receptor-1 [PDF]
, 2013 Whether peptidases present in vascular cells can activate prodrugs active on vascular cells has been tested with 2 potential latent ligands of the histamine H1 receptor (H1R). First, a peptide consisting of the antihistamine cetirizine (CTZ) condensed at
Charest-Morin??, Xavier +3 more
core +1 more source
The Effects of Histaminergic Agents in the Nucleus ccumbens of Rats in the Elevated Plus-Maze Test of Anxiety [PDF]
Iranian Journal of Psychiatry, 2010 "n Objective: "n The nucleus accumbens (NAc) receive histaminergic neurons from tuberomammillary nuclei. There are reports indicating that central histamine systems are involved in many physiological behavioral processes, including anxiety.
Ameneh Rezayof +2 more
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