Results 1 to 10 of about 319,341 (367)

Pyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream forms. [PDF]

PLoS ONE, 2013
BackgroundAfrican trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host, but it is unknown whether either process is essential to the parasite.Methodology/principal findingsPyrimidine requirements for
Juma A M Ali, Daniel N A Tagoe, Jane C Munday, Anne Donachie, Liam J Morrison, Harry P de Koning   +5 more
doaj   +8 more sources

Pyrimidine Biosynthesis and Ribonucleoside Metabolism in Species of Pseudomonas

Fermentation, 2023
Pyrimidine biosynthesis and ribonucleoside metabolism in species of Pseudomonas was the focus of this review, in relation to their current taxonomic assignments in different homology groups.
Thomas P. West
doaj   +1 more source

Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, in which the prognosis is determined by liver fibrosis.
P. Luukkonen, I. Sakuma, R. C. Gaspar, M. Mooring, Ali R. Nasiri, M. Kahn, Xian-Man Zhang, Dongyan Zhang, H. Sammalkorpi, A. Penttilä, M. Orho-Melander, J. Arola, A. Juuti, Xuchen Zhang, Dean Yimlamai, H. Yki-Järvinen, K. Petersen, G. Shulman   +17 more
semanticscholar   +1 more source

Synthesis and Anticancer Evaluations of Novel Thiazole Derivatives Derived from 4-Phenylthiazol-2-amine

Acta Chimica Slovenica, 2021
Many novel thiazole derivatives were designed and synthesized using 4-phenylthiazol-2-amine. The reactivity of the latter compound toward different chemical reagents was studied.
Amira E. M. Abdallah, Rafat M. Mohareb, Maher H. E. Helal, Germeen J. Mofeed   +3 more
doaj   +1 more source

Design, synthesis and antitumor activity of coumarin, isoxazole, pyrazole, pyridine and pyrimidine compounds: 3β-hydroxypregn-5-ene-20-one derivatives [PDF]

Acta Poloniae Pharmaceutica, 2023
In continuation of our reserach for synthesizing heterocyclic derivatives with a broad range of biological activities, the current research was performed to synthesize 3β-hydroxypregn-5-ene-20-one derivatives of coumarin, isoxazole, pyrazole, pyridine ...
Karam A. El-Sharkawy, Hassan A. Alhazmi, Asim Najmi, Mohammed AlBratty, Asaad Khalid, Rym Hassani, Sadique A. Javed   +6 more
doaj   +1 more source

Identifying the wide diversity of extraterrestrial purine and pyrimidine nucleobases in carbonaceous meteorites

Nature Communications, 2022
The lack of pyrimidine diversity in meteorites remains a mystery since prebiotic chemical models and laboratory experiments have predicted that these compounds can also be produced from chemical precursors found in meteorites.
Y. Oba, Y. Takano, Y. Furukawa, T. Koga, D. Glavin, J. Dworkin, H. Naraoka   +6 more
semanticscholar   +1 more source

High-throughput continuous evolution of compact Cas9 variants targeting single-nucleotide-pyrimidine PAMs

Nature Biotechnology, 2022
Directed evolution creates new compact Cas9 variants that target most single pyrimidine nucleotide PAMs. Despite the availability of Cas9 variants with varied protospacer-adjacent motif (PAM) compatibilities, some genomic loci—especially those with ...
Tony P. Huang, Zachary J. Heins, Shannon M Miller, Brandon G. Wong, P. A. Balivada, Tina Wang, Ahmad S. Khalil, David R. Liu   +7 more
semanticscholar   +1 more source

Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity

Nature Metabolism, 2021
Cytosolic mitochondrial DNA (mtDNA) elicits a type I interferon response, but signals triggering the release of mtDNA from mitochondria remain enigmatic.
Hans-Georg Sprenger, T. MacVicar, Amir Bahat, Kaitlin Fiedler, Steffen Hermans, Denise Ehrentraut, Katharina Ried, Dusanka Milenkovic, Nina A. Bonekamp, N. Larsson, H. Nolte, Patrick Giavalisco, T. Langer   +12 more
semanticscholar   +1 more source

Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine

Frontiers in Oncology, 2021
Metabolic rewiring is considered as a primary feature of cancer. Malignant cells reprogram metabolism pathway in response to various intrinsic and extrinsic drawback to fuel cell survival and growth.
Wanyan Wang, Jiayan Cui, Hui Ma, Weiqiang Lu, Jin Huang   +4 more
semanticscholar   +1 more source

Synthesis, characterization and theoretical studies of novel pyrimidine derivatives as potential corrosion inhibitors [PDF]

Journal of the Serbian Chemical Society, 2020
In this study, five new pyrimidine derivatives were synthesized and characterized by characterization methods such as 1H-NMR, 13C-NMR, FT- -IR and elemental analysis.
Akbas Esvet, Yildiz Ela, Erdogan Ahmet
doaj   +1 more source