Results 1 to 10 of about 197,991 (343)

Pyrimidine Biosynthesis and Ribonucleoside Metabolism in Species of Pseudomonas

Fermentation, 2023
Pyrimidine biosynthesis and ribonucleoside metabolism in species of Pseudomonas was the focus of this review, in relation to their current taxonomic assignments in different homology groups.
Thomas P. West
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Synthesis and Anticancer Evaluations of Novel Thiazole Derivatives Derived from 4-Phenylthiazol-2-amine

Acta Chimica Slovenica, 2021
Many novel thiazole derivatives were designed and synthesized using 4-phenylthiazol-2-amine. The reactivity of the latter compound toward different chemical reagents was studied.
Amira E. M. Abdallah, Rafat M. Mohareb, Maher H. E. Helal, Germeen J. Mofeed   +3 more
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Design, synthesis and antitumor activity of coumarin, isoxazole, pyrazole, pyridine and pyrimidine compounds: 3β-hydroxypregn-5-ene-20-one derivatives [PDF]

Acta Poloniae Pharmaceutica, 2023
In continuation of our reserach for synthesizing heterocyclic derivatives with a broad range of biological activities, the current research was performed to synthesize 3β-hydroxypregn-5-ene-20-one derivatives of coumarin, isoxazole, pyrazole, pyridine ...
Karam A. El-Sharkawy, Hassan A. Alhazmi, Asim Najmi, Mohammed AlBratty, Asaad Khalid, Rym Hassani, Sadique A. Javed   +6 more
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Synthesis, characterization and theoretical studies of novel pyrimidine derivatives as potential corrosion inhibitors [PDF]

Journal of the Serbian Chemical Society, 2020
In this study, five new pyrimidine derivatives were synthesized and characterized by characterization methods such as 1H-NMR, 13C-NMR, FT- -IR and elemental analysis.
Akbas Esvet, Yildiz Ela, Erdogan Ahmet
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Structure-Based Designing, Solvent Less Synthesis of 1,2,3,4-Tetrahydropyrimidine-5-carboxylate Derivatives: A Combined In Vitro and In Silico Screening Approach

Molecules, 2021
Objective: In this study, small molecules possessing tetrahydropyrimidine derivatives have been synthesized having halogenated benzyl derivatives and carboxylate linkage. As previously reported, FDA approved halogenated pyrimidine derivatives prompted us
Uzma Arshad, Sibtain Ahmed, Nusrat Shafiq, Zaheer Ahmad, Aqsa Hassan, Naseem Akhtar, Shagufta Parveen, Tahir Mehmood   +7 more
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Synthesis of Novel Tryptamine Derivatives and Their Biological Activity as Antitumor Agents

Molecules, 2021
We synthesized five novel tryptamine derivatives characterized by the presence of an azelayl chain or of a 1,1,1-trichloroethyl group, in turn connected to another heterocyclic scaffold.
Giorgia Simonetti, Carla Boga, Joseph Durante, Gabriele Micheletti, Dario Telese, Paolo Caruana, Andrea Ghelli Luserna di Rorà, Fabio Mantellini, Samantha Bruno, Giovanni Martinelli, Natalia Calonghi   +10 more
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A Review on Fused Pyrimidine Systems as EGFR Inhibitors and Their Structure–Activity Relationship

Frontiers in Chemistry, 2022
Epidermal growth factor receptor (EGFR) belongs to the family of tyrosine kinase that is activated when a specific ligand binds to it. The EGFR plays a vital role in the cellular proliferation process, differentiation, and apoptosis.
Tanuja T. Yadav, Gulam Moin Shaikh, Maushmi S. Kumar, Meena Chintamaneni, Mayur YC   +4 more
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Genome-Wide Identification of Pseudomonas aeruginosa Genes Important for Desiccation Tolerance on Inanimate Surfaces

mSystems, 2022
Pseudomonas aeruginosa is an opportunistic pathogen prevalent in the environment and in health care settings. Transmission in the health care setting occurs through human-human interactions and/or contact with contaminated surfaces.
Sardar Karash, Timothy L. Yahr
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Hybrides of Alkaloid Lappaconitine with Pyrimidine Motif on the Anthranilic Acid Moiety: Design, Synthesis, and Investigation of Antinociceptive Potency

Molecules, 2020
Convenient and efficient routes to construct hybrid molecules containing diterpene alkaloid lappaconitine and pyrimidine fragments are reported. One route takes place via first converting of lappaconitine to 1-ethynyl-lappaconitine, followed by the ...
Kirill P. Cheremnykh, Victor A. Savelyev, Sergey A. Borisov, Igor D. Ivanov, Dmitry S. Baev, Tatyana G. Tolstikova, Valentin A. Vavilin, Elvira E. Shults   +7 more
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3-(1-Cyclohexyl-2-(cyclohexylamino)-4-(4-ethoxyphenyl)-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methylquinoxalin-2(1H)-one

Molbank, 2022
The reaction of 3-cyclohexyl-2-(cyclohexylimino)-6-(4-ethoxyphenyl)-5-(4-methyl-3-oxo-3,4-dihydroquinoxalin-2-yl)-2,3-dihydro-4H-1,3-oxazin-4-one with ammonium acetate afforded 3-(1-cyclohexyl-2-(cyclohexylamino)-4-(4-ethoxyphenyl)-6-oxo-1,6 ...
Ekaterina E. Khramtsova, Svetlana O. Kasatkina, Maksim V. Dmitriev, Andrey N. Maslivets   +3 more
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