Results 1 to 10 of about 188,355 (366)
Studies in pyrimidine metabolism [PDF]
Journal of Biological Chemistry, 1920 By partial hydrolysis of yeast nucleic acid, preparations containing pyrimidines as the only nitrogenous constituents were prepared and administered to rabbits. Uracil nucleoside when administered per os, subcutaneously or intraperitoneally caused an increased excretion of urea often much more than enough to account for the nitrogen administered.
Darrell M. Wilson
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A Search for Interstellar Pyrimidine [PDF]
Mon.Not.Roy.Astron.Soc.345:650,2003, 2003 We have searched three hot molecular cores for submillimeter emission from the nucleic acid building-block pyrimidine. We obtain upper limits to the total pyrimidine (beam-averaged) column densities towards Sgr B2(N), Orion KL and W51 e1/e2 of 1.7E+14 cm^{-2}, 2.4E+14 cm^{-2} and 3.4E+14 cm^{-2}, respectively.
H. C. Huang +6 more
arxiv +5 more sources
In Plane Vibration of Pyrimidine and some Deuterated Pyrimidines [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 1991 On the basis of 102 assigned frequencies to in plane vibrations of pyrimidine, pyrimidine-2-d2, pyrimidine-2, 5-d2, pyrimidine-4,6-d2, pyrimidine-2,4,6-d3 and pyrimidine-d4, 35 valance force field constants including 14 principals and 21 interaction ...
F. Milani Nejad,
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Cross-Section Calculations for Electron-Impact Ionization of Pyrimidine Molecule and Its Halogenated Derivatives: 2-Chloropyrimidine, 5-Chloropyrimidine, 2-Bromopyrimidine and 5-Bromopyrimidine [PDF]
MoleculesThe total cross-sections for the single electron-impact ionization of pyrimidine (C4H4N2), 2-chloropyrimidine (2-C4H3ClN2), 5-chloropyrimidine (5-C4H3ClN2), 2-bromopyrimidine (2-C4H3BrN2) and 5-bromopyrimidine (5-C4H3BrN2) molecules have been calculated ...
Bożena Żywicka, Paweł Możejko
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Pyrimidine Biosynthesis and Ribonucleoside Metabolism in Species of Pseudomonas
Fermentation, 2023 Pyrimidine biosynthesis and ribonucleoside metabolism in species of Pseudomonas was the focus of this review, in relation to their current taxonomic assignments in different homology groups.
Thomas P. West
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Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy
Cells, 2022 Nucleotides are synthesized through two distinct pathways: de novo synthesis and nucleoside salvage. Whereas the de novo pathway synthesizes nucleotides from amino acids and glucose, the salvage pathway recovers nucleosides or bases formed during DNA or ...
M. Walter, P. Herr
semanticscholar +1 more source
Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine
Frontiers in Oncology, 2021 Metabolic rewiring is considered as a primary feature of cancer. Malignant cells reprogram metabolism pathway in response to various intrinsic and extrinsic drawback to fuel cell survival and growth.
Wanyan Wang +4 more
semanticscholar +1 more source
Pyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream forms. [PDF]
PLoS ONE, 2013 African trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host, but it is unknown whether either process is essential to the parasite.Pyrimidine requirements for growth were investigated using strictly
Juma A M Ali +5 more
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A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma
bioRxiv, 2021 Diffuse midline glioma (DMG) is a uniformly fatal pediatric cancer driven by oncohistones that do not readily lend themselves to drug development.
Sharmistha Pal +15 more
semanticscholar +1 more source
Frontiers in Chemistry, 2022 In this study, twenty novel pyrimidine derivatives bearing a 1,3,4-thiadiazole skeleton were designed and synthesized. Then their antifungal activity against Botrytis cinereal (B. cinereal), Botryosphaeria dothidea (B. dothidea), and Phomopsis sp.
Nianjuan Pan +4 more
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