Results 91 to 100 of about 197,991 (343)
1-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
IUCrData, 2018 The title molecule, C6H6N4O, is essentially planar [dihedral angle between the rings = 0.46 (9)°]. The crystal structure consists of sheets of molecules lying parallel to (\overline{1}11) formed by a combination of N—H...O, C—H...O and C—H...H hydrogen ...
Mohamed El Hafi +5 more
doaj +1 more source
Metabolic alterations in human pulmonary artery smooth muscle cells treated with PDGF‐BB
Animal Models and Experimental Medicine, EarlyView.Metabolic abnormalities are considered to play a key regulatory role in vascular remodeling of pulmonary arterial hypertension. We analyzed the metabolome in the culture supernatants of human pulmonary artery smooth muscle cells (PASMC) during the malignant proliferation phenotype transition via a targeted metabolomics method. Significant and extensive
Meng‐Jie Zhang +9 more
wiley +1 more source
Novel One-Pot Synthesis of Pyrazolopyranopyrimidinones Using Newly Produced γ-Alumina Nanoparticles as Powerful Catalyst [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2018 g-Alumina nanoparticles (g-Al2O3 NPs) were prepared via a new and simple synthetic route and characterized by field emission scanning electron microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy.
Sajad Kiani +4 more
doaj
Acta Crystallographica Section E: Crystallographic Communications, 2019 In 1-(2-iodobenzoyl)-4-(pyrimidin-2-yl)piperazine, C15H15IN4O, the central piperazine ring adopts an almost perfect chair conformation with the pyrimidine substituent in an equatorial site.
Ninganayaka Mahesha +4 more
doaj +1 more source
Endogenously Triggered DNAzyme‐Based Nanostructures for Gene‐Combined Therapy
Advanced NanoBiomed Research, EarlyView.DNAzymes show great promise for gene regulation and therapeutic use via controlled release triggered by endogenous factors. This review summarizes recent advances in designing and constructing nanoscale platforms enabling endogenously triggered release of DNAzyme.
Theoneste Muyizere +4 more
wiley +1 more source
Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides
Nature Communications, 2017 Understanding prebiotic nucleotide synthesis is a long standing challenge thought to be essential to elucidating the origins of life on Earth. Recently, remarkable progress has been made, but to date all proposed syntheses account separately for the ...
Shaun Stairs +5 more
semanticscholar +1 more source
Pyrimidine biosynthesis in Pseudomonas veronii and its regulation by pyrimidines
Microbiological Research, 2012 Pyrimidine biosynthesis in the nutritionally versatile bacterium Pseudomonas veronii ATCC 700474 appeared to be controlled by pyrimidines. When wild type cells were grown on glucose in the presence of uracil, four enzyme activities were depressed while all five enzyme activities increased in succinate-grown cells supplemented with uracil.
openaire +3 more sources
Angewandte Chemie, EarlyView.Wir berichten über die modulare Synthese ungesättigter PV‐Reagenzien ausgehend von Triethinyl‐Phosphinoxid mittels CuAAC. Diethinyl‐Triazolyl‐Phosphinoxide ermöglichen das schnelle, selektive und stabile Rebridging von Antikörper‐Disulfidbrücken, wie am Beispiel eines selektiv wirksamen Antikörper‐Wirkstoff‐Konjugats gezeigt wird.
Christian E. Stieger +5 more
wiley +1 more source
RESEARCHES ON PYRIMIDINES. XCI. ALKYLATION OF 2-MERCAPTO-PYRIMIDINES.
Journal of the American Chemical Society, 1921 n ...
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Recent progress of pyrimidine derivatives for high-performance organic light-emitting devices
, 2018 . Pyrimidine is an electron-deficient azaaromatic compound containing two nitrogen atoms at 1, 3-positions that plays a key role as an organic semiconductor or semiconducting material. Because of the high electron-accepting property induced by C═N double
Ryutaro Komatsu +2 more
semanticscholar +1 more source