Results 161 to 170 of about 314,968 (285)

Metabolic profiling reveals channeled de novo pyrimidine and purine biosynthesis fueled by mitochondrially generated aspartic acid in cancer cells. [PDF]

Nat Commun
Pareek V, Benkovic S.
europepmc   +1 more source

Synthesis, spectral characterization and anticancer activity of novel pyrimidine derivatives

, 2020
Saleha Banu, K. Giribabu, R. Senthamarai, Mohamed Sultan Mohamed Jaabir   +3 more
openalex   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Metabolic Dependency on De Novo Pyrimidine Synthesis is a Targetable Vulnerability in Platinum Resistant Ovarian Cancer. [PDF]

Cancer Res
Cardenas H, Wang Y, Zhao G, Hao DX, Isac AM, Hernandez V, Kim U, Qiang W, Zhang HF, Matei D.   +9 more
europepmc   +1 more source

Photopharmacology beyond azobenzene photoswitches

Responsive Materials, EarlyView.
Photopharmacology is advancing beyond traditional azobenzene photoswitches by developing new photoresponsive molecules with improved thermal stability, efficiency, and long‐wavelength activation, enhancing their potential for precise biomedical applications.
Huichao Guo, Jinghong Dai, Long Deng, Zhiwei Zhang, He Tian, Junji Zhang   +5 more
wiley   +1 more source

Roles of nucleotide metabolism in pancreatic cancer. [PDF]

Front Immunol
Liu Q, Liu J, Wang S, Bao N, Zhao X, Wang L.   +5 more
europepmc   +1 more source

Peptide nucleic acid biosensors: Structure–interface interactions, electrochemical signal strategies, and diagnostic applications

VIEW, EarlyView.
This review discusses the structural and functional properties of peptide nucleic acid (PNA)‐based biosensors, emphasizing their sensitivity, enzymatic resistance, and diagnostic potential. It presents a comparative analysis of detection limits across sensor designs, focusing on probe immobilization, electrode composition, and signal amplification. The
Younghwan Kim, Swomitra Kumar Mohanty
wiley   +1 more source

From Chains to Chromophores: Tailored Thermal and Linear/Nonlinear Optical Features of Asymmetric Pyrimidine-Coumarin Systems. [PDF]

Molecules
Nicolas P, Abdallah S, Chen D, Rizzi G, Jeannin O, Clays K, Bellec N, Bilgin-Eran B, Akdas-Kiliç H, Malval JP, Van Cleuvenbergen S, Camerel F.   +11 more
europepmc   +1 more source

Bionic nanobombs target nasopharyngeal carcinoma to enhance the efficacy of chemoradiotherapy by destroying DNA damage repair systems

VIEW, EarlyView.
A bionic nanomedicine system with core–shell structure (Nm‐pAu/CP/KU) was constructed. PEGylated gold nanoparticles (pAu) were loaded with cisplatin (CP) and a radiochemotherapy sensitizer (KU‐60019) to form the core pAu/CP/KU, and homologous nasopharyngeal carcinoma cell membrane vesicles (Nm) were used as the shell.
Junhua Zhang, Xinying Xiang, Xinmin Nie, Jian Li, Rong Gui   +4 more
wiley   +1 more source

Comparative Study of UVA Filtering Compounds 2‑Methyl/2-Amino Pyrimidine Derivatives of Avobenzone under Acidic Conditions. [PDF]

ACS Omega
Krishnappa R, Shit S, Dey P, Nayak A, Sahoo DK, Shaik K, Sonti R, Raghothama S, Gowd KH.   +8 more
europepmc   +1 more source