Results 181 to 190 of about 319,341 (367)

Synthesis and Biological Activity of some New Pyrimidines

, 1989
S. EL-BAHAIB, M. G. ASSY
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Design, Synthesis, Bioevaluation, and Bioinformatics Study of 5‐Benzylidene Hydantoin Derivatives as Novel Tyrosine Kinase Inhibitors

ChemistryOpen, EarlyView.
A series of 5‐benzylidene hydantoin derivatives is synthesized and evaluated against eight receptor tyrosine kinases (RTKs). Several compounds show selective and moderate inhibition of human epidermal growth factor receptor 2 (HER2). Molecular docking reveals key interactions with the HER2 active site, highlighting the potential of 5‐benzylidene ...
Muhammad Naufal, Elvira Hermawati, Ade Danova, Ika Wiani Hidayat, Jamaludin Al‐Anshori   +4 more
wiley   +1 more source

P058: Design of the prospective study of the clinical, laboratory, and dietary determinates of outcomes in purine and pyrimidine metabolism disorders

Genetics in Medicine Open
Shannon Haines, Katharine Chaillet, Oleg Shchelochkov   +2 more
doaj   +1 more source

Inhibition of histamine release by purine and pyrimidine derivatives

, 1982
Kazuhiro Shimamura, Masahiro Nishibori, Hiroshi Yokoyama, Kohji Tsutsumi, Kiyomi Saeki   +4 more
openalex   +1 more source

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source

A deconstruction–reconstruction strategy for pyrimidine diversification

Nature
Benjamin J H Uhlenbruck, Celena M Josephitis, Louis de Lescure, Robert S Paton, A. McNally   +4 more
semanticscholar   +1 more source

Synthesis of Pyrido[2,3‐d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor‐Targeted Molecular Docking Toward Novel Anticancer Leads

ChemistryOpen, EarlyView.
New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha, Sami A. Al‐Hussain, Basant Farag, AbdElAziz A. Nayl, Wesam Hussein, Abdelwahed R. Sayed, Magdi E. A. Zaki   +6 more
wiley   +1 more source

Synthesis, DNA-binding and antiproliferative activity of N-(Nitrogen heterocyclic) norcantharidin acylamide acid

Open Chemistry, 2009
Zhu Wen-Zhong, Hu Rui-Ding, Lin Qiu-Yue, Wang Xiao-Xia, Zheng Xiao-Liang   +4 more
doaj   +1 more source

The ketogenic diet alters microbiome‐metabolome profiles to improve West syndrome therapy

Pediatric Investigation, EarlyView.
The ketogenic diet alleviates West syndrome by reshaping gut microbiota (increasing Bacteroides, Parabacteroides, and reducing Escherichia and Bifidobacterium), and modulating metabolites—including anticonvulsant lipids (e.g., capric acid), suppressed harmful lipids (e.g., 2‐methylbutyroylcarnitine), and amino acids and analogs (e.g., 3‐sulfinoalanine)—
Gan Xie, Qian Zhou, Jianxiang Liao, Yuejie Zheng, Wenjian Wang, Kunling Shen   +5 more
wiley   +1 more source

Discovery of 1-((2R,4aR,6R,7R,7aR)-2-Isopropoxy-2-oxidodihydro-4H,6H-spiro[furo[3,2-d][1,3,2]dioxaphosphinine-7,2′-oxetan]-6-yl)pyrimidine-2,4(1H,3H)-dione (JNJ-54257099), a 3′-5′-Cyclic Phosphate Ester Prodrug of 2′-Deoxy-2′-Spirooxetane Uridine Triphosphate Useful for HCV Inhibition

, 2016
Tim H. M. Jonckers, Abdellah Tahri, Leen Vijgen, Jan Martin Berke, Sophie Lachau‐Durand, Bart Stoops, Jan Snoeys, Laurent Leclercq, Lotke Tambuyzer, Tse‐I Lin, Kenny Simmen, Pierre Raboisson   +11 more
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