Results 181 to 190 of about 290,598 (376)

A Ketol‐Acid Reductoisomerase Inhibitor That Has Antituberculosis and Herbicidal Activity

Chemistry – A European Journal, EarlyView.
1a and 1f are potent inhibitors of ketolacid reductoisomerase (KARI). 1f has good antituberculosis activity and 1a has herbicidal activity against Brassica campestris and Amaranthus retroflexus. Abstract Ketol‐acid reductoisomerase (KARI) is a target for the development of new biocidal agents. This is based on its essential role in branched chain amino
Xin Lin, Julia L. Kurz, Yong‐Hong Li, Shun Jie Wun, Thierry Lonhienne, Ross P. McGeary, Nicholas P. West, Gerhard Schenk, Jian‐Guo Wang, Luke W. Guddat   +9 more
wiley   +1 more source

Tailored Watson–Crick Pairing Partners for Xanthosine in RNA

Chemistry – A European Journal, Accepted Article.
The deamination of guanosine nucleobases results in the formation of xanthosine (X)‐containing RNA. This process formally resembles adenine deamination (A‐to‐I editing). The biological significance and basic chemical consequences of X‐modified RNA are poorly understood.
Ronald Micura, Stefan Mair, Anna Rázková, Karl Brillet, Catherina Gasser, Eric Ennifar   +5 more
wiley   +1 more source

Syntheses of Pyrimidine Derivatives. XIV

, 1959
Akira Takamizawa, Kanji Tokuyama
openalex   +2 more sources

Antiprotozoal activity of highly substituted pyrazole and pyrimidine derivates

ChemMedChem, Accepted Article.
To further extend the structure‐activity relationships of previously reported antimalarial anilino‐pyrazoles VI, trisubstituted pyrazoles 13‐15 and pyrimidines 16 and 17 were designed and synthesized. The novel derivatives were prepared thorough a divergent, chemo‐selective approach starting from N,S‐acetal intermediates.
Matteo Lusardi, Nicoletta Basilico, Erika Iervasi, Chiara Brullo, Silvia Parapini, Marco Ponassi, Camillo Rosano, Andrea Spallarossa   +7 more
wiley   +1 more source

PYRIMIDINE METABOLISM

, 1957
E.S. Canellakis
openalex   +1 more source

Targeting Ubiquitin‐Specific Protease 7 with Novel 5‐Amino‐Pyrazole Inhibitors: Design, Synthesis, and Biological Evaluation

ChemMedChem, EarlyView.
Ubiquitin‐specific protease 7 (USP‐7) is a novel target for anticancer therapy. To further extend the structure–activity relationships of the previously USP‐7 inhibitor STIRUR‐41, a library of 5‐aminopyrazoles is reported. 1d shows a potency comparable to lead compound STIRUR‐41 and promising in silico and in vitro pharmacokinetic properties ...
Matteo Lusardi, Elva Morretta, Andrea Spallarossa, Maria Chiara Monti, Camillo Rosano, Erika Iervasi, Marco Ponassi, Matteo Mori, Fiorella Meneghetti, Chiara Brullo   +9 more
wiley   +1 more source

Studies on Pyrimidine Derivatives. I

, 1958
Kenzo Sirakawa
openalex   +2 more sources

INCORPORATION OF FORMATE-C ¹⁴ INTO THE PYRIMIDINE MOIETY OF THIAMINE, [PDF]

, 1959
Martin J. Pine, Robert Guthrie
openalex   +1 more source

Synthesis and biological characterization of 4,4‐difluoro‐3(phenoxymethyl)piperidine scaffold as dopamine 4 receptor (D4R) antagonist in vitro tool compounds

ChemMedChem, Accepted Article.
We report the discovery and characterization of a novel series of 4,4‐difluoropiperidine etherbased dopamine D4 receptor antagonists. Structure‐activity relationship studies led to the identification of compound 14a, which displays exceptional binding affinity for the D4 receptor (Ki = 0.3 nM) and remarkable selectivity over other dopamine receptor ...
Saeedeh Saeedi, Sumaiya Nahid, Anish Vadukoot, Corey R Hopkins   +3 more
wiley   +1 more source

Synthesis, DNA-binding and antiproliferative activity of N-(Nitrogen heterocyclic) norcantharidin acylamide acid

Open Chemistry, 2009
Zhu Wen-Zhong, Hu Rui-Ding, Lin Qiu-Yue, Wang Xiao-Xia, Zheng Xiao-Liang   +4 more
doaj   +1 more source