Results 211 to 220 of about 151,536 (281)

Ultraviolet C (UV‐C) Light Therapy Inhibits Pathogens Associated With Equine Keratomycosis at Different Corneal Depths—An Ex Vivo Study

Veterinary Ophthalmology, EarlyView.
ABSTRACT Objective To assess if an inexpensive, commercially available ultraviolet C (UV‐C) light device with a peak emission of 275 nm can inhibit equine keratomycosis‐associated pathogens located at different corneal depths in an ex vivo model. Methods A controlled, randomized experimental design.
Mona Hoerdemann, Dipak K. Sahoo, Rachel A. Allbaugh, Melissa A. Kubai   +3 more
wiley   +1 more source

In Vitro Evaluation of Sugar-Conjugated Thienopyrimidinone Derivatives with Possible Neuroprotective and Antioxidant Effects. [PDF]

Int J Mol Sci
Alshamari AK, Aboulthana WM, Mansour H, Abu-Zied KM, Alshammari OAO, Morsy NM, Alsaif NOS, Alshammari MZ, Nossier ES, Hassan NA.   +9 more
europepmc   +1 more source

Role of S1P‐ and Rho‐kinase signalling in age‐related myogenic tone deficiency in murine resistance arteries

Experimental Physiology, EarlyView.
Abstract Ageing is a risk factor for cardiovascular and neurodegenerative diseases. The myogenic response in resistance arteries is responsible for basal (myogenic) tone and blood flow autoregulation. G‐protein‐coupled receptors and G12/RhoA/Rho kinase are implicated in myogenic tone (MT), and we aimed to clarify their role in pressure sensing and ...
Gry Freja Skovsted, Alex Aupetit, Karl Björling, Kristian Agmund Haanes, Susanne Syberg, Niklas Rye Jørgensen, Blanca I. Aldana, Hirotsugu Tsuchimochi, Mark T. Waddingham, Kristine Freude, James Todd Pearson, Lars Jørn Jensen   +11 more
wiley   +1 more source

Thienopyrimidine scaffolds as promising antimicrobial agents: synthesis, biological evaluation, DFT analysis and molecular docking. [PDF]

RSC Adv
Sayed M, Naguib MA, Mohammed AAK, Hassanien R, Tolba MS, Ahmed M.   +5 more
europepmc   +1 more source

On why cancer cells require a great amount of glucose

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract The traditional thinking has been that cancer cells require a great amount of glucose to support their rapid growth, but the reality may be different. We have previously demonstrated that all cancer cells in The Cancer Genome Atlas harbor persistent Fenton reactions in their cytosol, which generate OH− ${\text{OH}}^{-}$ and ultimately kill the
Xuechen Mu, Aoran Liu, Rui Shi, Long Xu, Zhenyu Huang, Ye Zhang, Ying Xu   +6 more
wiley   +1 more source

Exploration and Characterization of the Antimalarial Activity of Pyrimidine-2,4-Diamines for which Resistance is Mediated by the ABCI3 Transporter. [PDF]

ChemMedChem
Mansouri M, Dans MG, Low Z, Loi K, Jarman KE, Penington JS, Qiu D, Lehane AM, Crespo B, Gamo FJ, Baud D, Brand S, Jackson PF, Cowman AF, Sleebs BE.   +14 more
europepmc   +1 more source

Insights into Novel Arylazopyrazolo[1,5-a]pyrimidines as Promising MurA Inhibitors and Antibiofilm Candidates: Design, Synthesis, Antimicrobial Evaluation, and Molecular Docking

Omkulthom Al kamaly, Amel S. Younes, Mona H. Ibrahim, Marwa F. Harras, Aisha A. Alsfouk, Rehab Sabour   +5 more
openalex   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Inhibitors of GapN-dependent NADPH supply as potential lead compounds for novel therapeutics against <i>Streptococcus pyogenes</i>. [PDF]

Virulence
Schütt I, Einwohlt P, Wandinger AM, Teuffel J, Wirsing R, Hlawatschke BH, Fehlauer HL, Bothe S, Bader N, Monaci E, Kreikemeyer B, Schindelin H, Wade RC, Fiedler T.   +13 more
europepmc   +1 more source

De novo pyrimidine synthesis is a collateral metabolic vulnerability in NF2-deficient mesothelioma

Duo Xu, Yanyun Gao, Shengchen Liu, Shiyuan Yin, Tong Hu, Haibin Deng, Tuo Zhang, Balázs Hegedűs, Thomas M. Marti, Patrick Dorn, Shun‐Qing Liang, Ralph A. Schmid, Ren‐Wang Peng, Yongqian Shu   +13 more
openalex   +1 more source