Results 211 to 220 of about 319,341 (367)

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Fluorinated pyrimidine 5-carboxamides as potential tools for MERTK targeted fluorine-18-PET-radioligand development. [PDF]

RSC Med Chem
Mudududdla R, Wong SW, Nguyen N, Xue L, Stashko MA, Wang X, Vivash L, Binder MD, Ackermann U, Bozikis YE, Kilpatrick TJ, Baell JB.   +11 more
europepmc   +1 more source

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, EarlyView.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

Chiral hypervalent iodine catalyzed stereoselective skeletal editing of pyrimidine fused heterocycles. [PDF]

Nat Commun
Sun WW, Xie YB, Wu B.
europepmc   +1 more source

Pyrimidine Ribonucleotides with Enhanced Selectivity as P2Y 6 Receptor Agonists: Novel 4-Alkyloxyimino, (S)-Methanocarba, and 5′-Triphosphate γ-Ester Modifications †

, 2020
Hiroshi Maruoka, Matthew O. Barrett, Hyojin Ko, Dilip K. Tosh, Artem Melman, Lauren E. Burianek, Рамачандран Баласубраманиан, Barkın Berk, Stefano Costanzi, T. Kendall Harden, Kenneth A. Jacobson   +10 more
openalex   +1 more source

Synthesen von Heterocyclen, CCVII Mesoionische Pyrimidine und Thiazine / Syntheses of Heterocycles, CCVII Mesoionic Pyrimidines and Thiazines [PDF]

, 1977
Erich Ziegler, W. Steiger, Charilaos Strangas   +2 more
openalex   +1 more source

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

The FEBS Journal, EarlyView.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source

Expanding Peptide Chemical Space via Acid-Mediated Arginine Modification. [PDF]

Org Lett
Sihag P, Kwon M, Misra A, Raj M.
europepmc   +1 more source

Enzymatic Incorporation of Emissive Pyrimidine Ribonucleotides

, 2008
Seergazhi G. Srivatsan, Yitzhak Tor
openalex   +1 more source

Exploring the use of dalfampridine (4‐aminopyridine) for treatment of ataxia in cerebellar stroke

PM&R, EarlyView.
Arjun Kotwal, Prashant Yadav, Veyola Rezkalla, Alison Mautner, Gilbert Siu   +4 more
wiley   +1 more source