Results 221 to 230 of about 319,341 (367)

Heterologous plastoquinone production using a newly identified O2‐dependent cyanobacterial hydroxylase

The FEBS Journal, EarlyView.
In this study, we confirm that PlqH is the hydroxylase operating in plastoquinone biosynthesis in photosynthetic cyanobacteria (Cyanobacteriia). Our phylogenetic analyses demonstrate that cyanobacterial PlqH homologues originated from hydroxylases involved in ubiquinone biosynthesis in bacteria. Plastoquinone production in Escherichia coli was achieved
Morgane Roger‐Margueritat, Margot Beltran, Juliette Schnoebelen, Laura Flandrin, Wafa Rezali, Eline Michel, Sophie S. Abby, Fabien Pierrel   +7 more
wiley   +1 more source

Dihydroorotate Dehydrogenase in Mitochondrial Ferroptosis and Cancer Therapy. [PDF]

Cells
Lee J, Roh JL.
europepmc   +1 more source

Discovery of a potent protein kinase D inhibitor: insights in the binding mode of pyrazolo[3,4-d]pyrimidine analogues

, 2017
Klaas Verschueren, Mathias Cobbaut, Joachim Demaerel, Lina Saadah, Arnout Voet, Johan Van Lint, Wim M. De Borggraeve   +6 more
openalex   +2 more sources

Synthesis, Characterization, Anti-Mycobacterial Evaluation and In-Silico Molecular Docking of Novel Isoxazole Clubbed Pyrimidine Derivatives

, 2021
Nagaraju Pappula, Ravichandra Sharabu
openalex   +2 more sources

Plant organelle C‐to‐U RNA editing factors can operate successfully in yeast (Saccharomyces cerevisiae) as an easily amenable eukaryotic system for their functional analysis

The FEBS Journal, EarlyView.
Plant‐type pentatricopeptide repeat proteins capable of C‐to‐U RNA editing perform faithfully when expressed in a new heterologous system, the yeast Saccharomyces cerevisiae. They were tested with constitutive and inducible expression and with a set of different solubility tags. PPR56, PPR65, and PPR78 from P.
Shyam Ramanathan, Annika Hanraths, Jingchan Xie, Mareike Schallenberg‐Rüdinger, Volker Knoop   +4 more
wiley   +1 more source

Targeting plasticity in the pyrimidine synthesis pathway potentiates macrophage-mediated phagocytosis in pancreatic cancer models. [PDF]

J Clin Invest
Zhao J, Li X, Li X, Ren P, Wu Y, Gong H, Wu L, Huang J, Wang S, Guo Z, Chen M, Zeng Z, Pan D.   +12 more
europepmc   +1 more source

Discovery of a new pyrimidine synthesis inhibitor eradicating glioblastoma-initiating cells [PDF]

, 2019
Smile Echizenya, Yukiko Ishii, Satoshi Kitazawa, Tadashi Tanaka, Shun Matsuda, Eriko Watanabe, Masao Umekawa, Shunsuke Terasaka, Kiyohiro Houkin, Tomohisa Hatta, Tohru Natsume, Yoshimasa Maeda, Shinichi Watanabe, Shinji Hagiwara, Tôru Kondo   +14 more
openalex   +1 more source

Novel Pyrimidine-5-carboxamide Compounds as NNMT Inhibitors for Treating Diabetes

, 2021
Ram W. Sabnis
openalex   +2 more sources

A novel approach to target skin photodamage: Topical application of salt inducible kinase inhibitors

International Journal of Cosmetic Science, EarlyView.
UV‐induced photodamage leads to increased DNA damage and elevated MMP levels, which degrade collagen and contribute to wrinkle formation. SLT‐001 and SLT‐008, novel cosmetic ingredients that target salt‐inducible kinase, help reverse this effect by enhancing DNA repair, reducing MMP expression and decreasing erythema, thereby mitigating photodamage ...
Inbal Rachmin, Béatrice Le Varlet, Claire Regazzetti, Thierry Passeron, Jinhua Wang, David E. Fisher, Philippe Schaison, Braham Shroot   +7 more
wiley   +1 more source

Response of <i>Escherichia coli</i> chemotaxis pathway to pyrimidine deoxyribonucleosides. [PDF]

Microbiol Spectr
Shah M, Xu W, Sourjik V.
europepmc   +1 more source