Results 231 to 240 of about 153,260 (279)

Correction to: De novo pyrimidine synthesis is a collateral metabolic vulnerability in NF2-deficient mesothelioma. [PDF]

EMBO Mol Med
Xu D, Gao Y, Liu S, Yin S, Hu T, Deng H, Zhang T, Hegedüs B, Marti TM, Dorn P, Liang SQ, Schmid RA, Peng RW, Shu Y.   +13 more
europepmc   +1 more source

Pyrimidine [PDF]

, 2017
openaire   +2 more sources

On why cancer cells require a great amount of glucose

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract The traditional thinking has been that cancer cells require a great amount of glucose to support their rapid growth, but the reality may be different. We have previously demonstrated that all cancer cells in The Cancer Genome Atlas harbor persistent Fenton reactions in their cytosol, which generate OH− ${\text{OH}}^{-}$ and ultimately kill the
Xuechen Mu, Aoran Liu, Rui Shi, Long Xu, Zhenyu Huang, Ye Zhang, Ying Xu   +6 more
wiley   +1 more source

Targeting plasticity in the pyrimidine synthesis pathway potentiates macrophage-mediated phagocytosis in pancreatic cancer models. [PDF]

J Clin Invest
Zhao J, Li X, Li X, Ren P, Wu Y, Gong H, Wu L, Huang J, Wang S, Guo Z, Chen M, Zeng Z, Pan D.   +12 more
europepmc   +1 more source

Structure‐Guided Optimization and Biological Validation of 1,3,4‐Thiadiazole‐Based SIRT2 Inhibitors Reinforcing Channel Entrance Interactions

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT SIRT2, the cytoplasmic member of the sirtuin family, is generally acknowledged to promote cancer and contribute to the progression of various pathologies, including neurodegeneration, inflammation, obesity, and bacterial infection through the deacetylation of target substrates.
Ahmet Bugra Aksel, Fikriye Ozgencil, Filiz Bakar‐Ates, Habibe Beyza Gunindi, Alberto Massarotti, Erva Ozkan, Selen Gozde Kaya, Mahmut Gozelle, Yesim Ozkan, Gokcen Eren   +9 more
wiley   +1 more source

Novel Dorsomorphin Derivatives: Molecular Modeling, Synthesis, and Bioactivity Evaluation. [PDF]

Biomolecules
Tzanetou EN, Liekens S, Kasiotis KM, Fokialakis N, Tsafantakis N, SanMartin R, Tzoupis H, Papavasileiou KD, Afantitis A, Haroutounian SA.   +9 more
europepmc   +1 more source

Acetyl‐Phosphate Dependent Protein Acetylation in Neisseria gonorrhoeae

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
The role of acetyl‐phosphate‐dependent non‐enzymatic protein acetylation in Neisseria gonorrhoeae was investigated through the deletion of the phosphotransacetylase (pta) and the acetate kinase (ackA) genes, this led to a decrease and increase in protein acetylation, respectively.
Ernesto F. D. Parga, Paige A. Wolverson, Mark O. Collins, Oliver Heaney, Joby Cole, Luke R. Green, Jonathan G. Shaw   +6 more
wiley   +1 more source

Fe₃O₄/cellulose/Zn-MOF: introduction of a new catalyst for the synthesis of tetrazolo[1,5-<i>a</i>]pyrimidine-6-carbonitriles and diphenyl-1,3-thiazoles under solvent-free conditions. [PDF]

RSC Adv
JahangirVazifeh M, Abdollahi-Basir MH, Sharifzadeh B, Shirini F.   +3 more
europepmc   +1 more source

Molecular Insights Into Canine Hepatocellular Carcinoma: A Cross‐Species Transcriptomic Comparison With Human HCC

Molecular Carcinogenesis, Volume 65, Issue 4, Page 523-536, April 2026.
ABSTRACT Canine hepatocellular carcinoma (HCC) requires further molecular characterization to identify diagnostic and therapeutic targets, and to establish whether dogs with this condition can model the human disease. Accordingly, we aimed to identify differentially expressed genes (DEGs) in canine HCC and evaluate cross‐species transcriptomic ...
Mohammad Arif, MD Nazmul Hasan, Nobuhiro Nozaki, Yutaro Ide, Yoshiyuki Akiyama, Shaohsu Wang, Most Shumi Akhter Shathi, Osamu Yamato, Naoki Miura   +8 more
wiley   +1 more source

Design, synthesis and anti-breast cancer activity evaluation of 6,7-dihydro-5<i>H</i>-pyrrolo[3,4-<i>d</i>]pyrimidine-based PARP1/ATR dual inhibitors. [PDF]

J Enzyme Inhib Med Chem
He ML, Wang ZH, Yao X, Ye LL, Du BQ, Wang CC, Chen YH, Wang XX, Luo H, Gao Y, Ye XY.   +10 more
europepmc   +1 more source