Results 231 to 240 of about 290,598 (376)

Aneuploidy generates enhanced nucleotide dependency and sensitivity to metabolic perturbation. [PDF]

Genes Dev
Magesh RY, Kaur AN, Keller FN, Frederick A, Tseyang T, Haley JA, Rivera-Nieves AM, Liang AC, Guertin DA, Spinelli JB, Elledge SJ, Watson EV.   +11 more
europepmc   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Interaction energies in hydrogen-bonded purine-pyrimidine triplets. [PDF]

, 1967
B. Pullman, P. Claverie, J. Caillet
openalex   +1 more source

EGFR Mutations and Resistance to Irreversible Pyrimidine-Based EGFR Inhibitors

Clinical Cancer Research, 2015
D. Ercan, H. Choi, C. Yun, M. Capelletti, Ting Xie, M. Eck, N. Gray, P. Jänne   +7 more
semanticscholar   +1 more source

The RNA demethylase FTO promotes glutamine metabolism in clear cell renal cell carcinoma through the regulation of SLC1A5. [PDF]

Sci Adv
Zhao M, Zhang D, Jiang H, Kuganesan N, Natarajan S, Pu L, Thakkar KN, Zhao H, Le QT, Giaccia AJ, Brooks JD, Peehl DM, Ye J, Rankin EB.   +13 more
europepmc   +1 more source

An investigation into the transcription factors and regulatory mechanisms of Aspergillus

Food Safety and Health, EarlyView.
Foodborne pathogen Aspergillus, a prevalent etiologic agent among filamentous fungi, are distinguished by a significant repertoire of transcription factors encoded within their genomes. These regulatory proteins are instrumental in orchestrating key biological processes, including cellular growth, secondary metabolite biosynthesis, mycotoxin production,
Yuxin Qin, Huawei Yu, Jun Tian
wiley   +1 more source

Studies in Vitro of Digestion and Absorption of Pyrimidine Nucleotides by the Intestine

, 1958
Tony Wilson, Darrell M. Wilson
openalex   +1 more source

Innovation of eco-friendly TiO2 nano catalyst for new pyrimidine carbonitiriles candidates, assessed for significant antioxidant activity, anti-inflammatory effects, and by insilico studies. [PDF]

PLoS One
Shehab WS, El-Farargy AF, El-Gazzar ARBA, Haikal HA, Mouneir SM, Emwas AM, Jaremko M, Abdellattif MH.   +7 more
europepmc   +1 more source

Exploring the Antidiabetic and Lipid‐Lowering Properties of Nepali Wild Turmeric (Curcuma aromatica): A Potential Natural Remedy

Food Safety and Health, EarlyView.
Curcuma aromatica rhizome ethanolic extracts (400 mg/kg) showed hypoglycemic and hypolipidemic activities in alloxan‐induced diabetic rats, comparable to standard drugs in reducing blood glucose levels. The extracts reduced serum cholesterol and triglycerides, increased HDL levels, and prevented weight loss.
Salma Khadka, Tshoisang Vaal, Sanjit Gurung, Keshav Dhakal, Ramesh Raj Padhaya, Sailendra Chaudhary, Bipindra Pandey   +6 more
wiley   +1 more source

THE FUNCTION OF OROTIC ACID IN THE BIOGENESIS OF PYRIMIDINES IN SLICES FROM REGENERATING LIVER

, 1952
Peter Reichard
openalex   +1 more source