Results 261 to 270 of about 314,968 (285)

Overcoming Curcumin's Limitations: Synthetic Derivatives in Diabetes and Cancer Management

Applied Research, Volume 4, Issue 6, December 2025.
Synthetic curcumin derivatives overcome curcumin's poor bioavailability through structural modifications, enhancing pharmacokinetics and therapeutic efficacy. These derivatives exhibit potent antidiabetic and anticancer activities, offering promising dual‐targeted interventions for non‐communicable diseases.
Adesola Oluwaseun Adeleye, Simon Mwaringa Dena, Oluwafemi O. Oguntibeju, Salam Titinchi, Chinyerum S. Opuwari   +4 more
wiley   +1 more source

Preparation and characterization of kaolin-[TMS]-NH₂ ⁺C(NO₂)₃ ^- as a novel heterogeneous nano-catalyst and its use in the synthesis of imidazo[1,2-<i>a</i>]pyrimidine and 1,2,4-triazolo[4,3-<i>a</i>]pyrimidines. [PDF]

RSC Adv
Dorostkar M, Nazemi-Nasyrmahale L, Shirini F.   +2 more
europepmc   +1 more source

Merkel Cell Carcinoma: Evolving Therapeutics, Continued Challenges

Head &Neck, Volume 47, Issue 12, Page 3414-3428, December 2025.
ABSTRACT Background Merkel Cell Carcinoma (MCC) is a rare, aggressive neuroendocrine malignancy with rising incidence, influenced by ultraviolet (UV) radiation and Merkel cell polyomavirus (MCPyV). Methods This review summarizes recent advances in MCC management, based on an analysis of current literature, focusing on immune checkpoint inhibitors (ICIs)
Hunter A. Holley, Maria Lyons, Barry O'Sullivan, Neville Shine, Robbie Woods, Orla McArdle, James Paul O'Neill   +6 more
wiley   +1 more source

Crystal structure of 1-phenyl-1<i>H</i>-pyrazolo-[3,4-<i>d</i>]pyrimidin-4(5<i>H</i>)-one. [PDF]

Acta Crystallogr E Crystallogr Commun
Akhmedova N, Ortikov I, Khasanova N, Zokhidov K, Turgunov K, Elmuradov B.   +5 more
europepmc   +1 more source

HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis. [PDF]

Cell Rep
Ikeda T, Hong S, Yoshida S, Srivastava SP, Kunamneni A, Yao Y, Khuperkar O, Basrur V, Kuang H, Kachman M, Raskind A, Baum H, Joshi A, Swaroop V, Thurman A, Kopasz-Gemmen O, Kandukuri S, Pradeepa FNU, Yonekura H, Lin JD, Inoki K.   +20 more
europepmc   +1 more source

DHODH-mediated mitochondrial redox homeostasis: a novel ferroptosis regulator and promising therapeutic target. [PDF]

Redox Biol
Cao J, Chen X, Chen L, Lu Y, Wu Y, Deng A, Pan F, Huang H, Liu Y, Li Y, Tong X, Du J.   +11 more
europepmc   +1 more source

Hybrid Molecules with Purine and Pyrimidine Derivatives for Antitumor Therapy: News, Perspectives, and Future Directions. [PDF]

Molecules
Iacob Ciobotaru S, Stefan CS, Nechita A, Matei MN, Lisa EL, Tutunaru D, Fulga I, Fulga A, Cristea Hohota AG, Dragostin OM.   +9 more
europepmc   +1 more source

Supramolecular Assembly of Graphene-Polyamine-PdS-CdS Photocatalysts for Synergistically Enhanced and Highly Effective Hydrogen Evolution from Water under Visible Light. [PDF]

Inorg Chem
Godino-Salido ML, Bartoli F, Valbuena-Rus AM, Vicidomini G, Gutiérrez-Valero MD, Abdelkader-Fernández VK, Savastano M, Bianchi A, López-Garzón R.   +8 more
europepmc   +1 more source

Uridine as a hub in cancer metabolism and RNA biology. [PDF]

Exp Mol Med
Choi KM, Berard BA, Yoon JH, Kim D.
europepmc   +1 more source