Results 41 to 50 of about 197,991 (343)

Recent Advances in Pyrimidine-Based Drugs

Pharmaceuticals
Pyrimidines have become an increasingly important core structure in many drug molecules over the past 60 years. This article surveys recent areas in which pyrimidines have had a major impact in drug discovery therapeutics, including anti-infectives ...
B. Nammalwar, R. Bunce
semanticscholar   +1 more source

Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells

PLoS Genetics, 2020
Glioblastoma is the most common and aggressive type of cancer in the brain; its poor prognosis is often marked by reoccurrence due to resistance to the chemotherapeutic agent temozolomide, which is triggered by an increase in the expression of DNA repair
M. Lafita-Navarro, Niranjan Venkateswaran, Jessica A. Kilgore, S. Kanji, Jungsoo Han, Spencer D. Barnes, Noelle S. Williams, M. Buszczak, S. Burma, Maralice Conacci-Sorrell   +9 more
semanticscholar   +1 more source

Synthesis of Pyrimidine Conjugates with 4-(6-Amino-hexanoyl)-7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine and Evaluation of Their Antiviral Activity

Molecules, 2022
A series of pyrimidine conjugates containing a fragment of racemic 7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine and its (S)-enantiomer attached via a 6-aminohexanoyl fragment were synthesized by the reaction of nucleophilic substitution of ...
Victor P. Krasnov, Vera V. Musiyak, Galina L. Levit, Dmitry A. Gruzdev, Valeriya L. Andronova, Georgii A. Galegov, Iana R. Orshanskaya, Ekaterina O. Sinegubova, Vladimir V. Zarubaev, Valery N. Charushin   +9 more
doaj   +1 more source

Uracil Compounds As Inhibitors For Glutamate Oxaloactate Tansaminase (GOT) In Serum Of Some Leukemia Patients [PDF]

Kirkuk Journal of Science, 2015
Effect of Uracil’s derivatives on enzyme glutamate oxaloacetate transaminase (GOT) for sample of normal human and some types of leukemia patients, acute lymphatic(ALL) (11 cases), acute mylosyticl (AML) (4 cases), acute mylomonocyticl (AMOL) (2cases ...
Nadia Q. Haj
doaj   +1 more source

Transcriptional reprogramming of nucleotide metabolism in response to altered pyrimidine availability in Arabidopsis seedlings

Frontiers in Plant Science, 2023
In Arabidopsis seedlings, inhibition of aspartate transcarbamoylase (ATC) and de novo pyrimidine synthesis resulted in pyrimidine starvation and developmental arrest a few days after germination.
Robert D. Slocum, Carolina Mejia Peña, Zhongchi Liu   +2 more
doaj   +1 more source

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

Nature, 2017
Metabolic reprogramming by oncogenic signals promotes cancer initiation and progression. The oncogene KRAS and tumour suppressor STK11, which encodes the kinase LKB1, regulate metabolism and are frequently mutated in non-small-cell lung cancer (NSCLC ...
Jiyeon Kim, Zeping Hu, L. Cai, Kailong Li, Eunhee Choi, B. Faubert, Divya Bezwada, J. Rodriguez-Canales, P. Villalobos, Yu-Fen Lin, Min Ni, K. Huffman, L. Girard, L. Byers, K. Unsal-Kaçmaz, C. G. Peña, J. Heymach, E. Wauters, J. Vansteenkiste, D. Castrillon, Benjamin P. C. Chen, I. Wistuba, D. Lambrechts, Jian Xu, J. Minna, R. Deberardinis   +25 more
semanticscholar   +1 more source

Synthesis of novel pyrimidine and fused pyrimidine derivatives [PDF]

European Journal of Chemistry, 2011
4-Amino-2-(benzylthio)-6-(4-methoxyphenyl)pyrimidine-5-carbonitrile ( 1 ) was prepared by treatment of s-benzylthiuronium chloride with 2-(4-methoxybenzylidene)malononitrile in ethanolic sodium hydroxide with hydrazine hydrate to afford the hydrazino derivative 2 , which was allowed to react with different electrophilic reagents to give the pyrimidine
Mahmoud R. Mahmoud, S. A. Shiba, M. F. Ismail, Ahmed K. El-Ziaty   +3 more
openaire   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

One-Pot Multicomponent Synthesis and Cytotoxic Evaluation of Novel 7-Substituted-5-(1H-Indol-3-yl)Tetrazolo[1,5-a] Pyrimidine-6-Carbonitrile

Molecules, 2020
A series of novel 7-substituted-5-(1H-indol-3-yl)tetrazolo[1,5-a]pyrimidine-6-carbonitrile was synthesized via a one-pot, three-multicomponent reaction of appropriate aldehydes, 1H-tetrazole-5-amine and 3-cyanoacetyl indole in catalytic triethylamine ...
Mohamed A. A. Radwan, Fahad M. Alminderej, Hanem M. Awad   +2 more
doaj   +1 more source

Synthesis of Some3-Chloro-2,3-dimethyl-1-phenylpyrazolidin-5-one [PDF]

Kirkuk Journal of Science, 2013
(E)-3-Chloro-4-arylidene-2,3-dimethyl-1-phenylpyrazolidin-5-one 1(a-c) which were used as synthon for synthesis of all target compounds were prepared from the reaction of 3-chloro-2,3-dimethyl-1-phenylpyrazolidin-5-one(Chlorophenazone)with aromatic ...
Moayed S.AL.Gawady, Shakir M. Saied, Moneera Y. Raoof   +2 more
doaj   +1 more source