Results 81 to 90 of about 121,011 (315)

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, EarlyView.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source

An Artificial Copper‐Michaelase Featuring a Genetically Encoded Bipyridine Ligand for Asymmetric Additions to Nitroalkenes

Angewandte Chemie, EarlyView.
An efficient artificial copper‐dependent Michaelase featuring a metal‐binding unnatural amino acid, e. g. bipyridyl alanine (BpyA), was optimized through directed evolution and applied in catalytic asymmetric additions of 2‐acetyl azaarenes to nitroalkenes.
Ru Jiang, Fabrizio Casilli, Andy‐Mark W. H. Thunnissen, Gerard Roelfes   +3 more
wiley   +2 more sources

Synthesis and Bioactivities Study of Novel Pyridylpyrazol Amide Derivatives Containing Pyrimidine Motifs

Frontiers in Chemistry, 2020
In this study, thirteen new pyridylpyrazolamide derivatives containing pyrimidine motifs were synthesized via six-step reactions. Bioassay results showed that some of the synthesized compounds revealed good antifungal properties against Sclerotinia ...
Wenneng Wu, Wenneng Wu, Meihang Chen, Qiang Fei, Yonghui Ge, Yingying Zhu, Haijiang Chen, Maofa Yang, Guiping Ouyang   +8 more
doaj   +1 more source

The Latest Advances in Mechanically Robust Self‐Healing Polyurea Based on Dynamic Chemistry

Advanced Science, EarlyView.
Solving the contradiction between strength, toughness, and self‐healing properties is extremely important to realize the breakthrough of polyurea applications. This review summarizes and discusses common strategies for the preparation of high‐performance and self‐healing polyurea materials based on dynamic chemistry, providing molecular‐level insights ...
Yujia Hao, Guangming Zhu
wiley   +1 more source

“Naked Nickel”‐Catalyzed Heteroaryl–Heteroaryl Suzuki–Miyaura Coupling

Angewandte Chemie, EarlyView.
We report that an air‐stable “naked nickel”, Ni(4‐CF3stb)3, can efficiently catalyze heteroaryl–heteroaryl Suzuki–Miyaura cross‐coupling (SMC) reactions in the absence of exogenous ligands. This protocol permits the construction of >15 different heterobiaryls containing multiple Lewis basic heteroatoms from a broad set of 6‐membered heteroaryl bromides
Rakan Saeb, Byeongdo Roh, Josep Cornella
wiley   +2 more sources

Fluorene–Triphenylamine-Based Bipolar Materials: Fluorescent Emitter and Host for Yellow Phosphorescent OLEDs

Applied Sciences, 2020
In this study, two new bipolar materials were designed and synthesized: N1-(9,9-diphenyl-9H-fluoren-2-yl)-N1-(4,6-diphenylpyrimidin-2-yl)-N4,N4-diphenylbenzene-1,4-diamine (FLU-TPA/PYR) and N1-(4-(4,6-diphenyl-1,3,5-triazin-2-yl)phenyl)-N1-(9,9-diphenyl ...
Ramanaskanda Braveenth, Hasu Jung, Keunhwa Kim, Bo Mi Kim, Il-Ji Bae, Miyoung Kim, Kyu Yun Chai   +6 more
doaj   +1 more source

Development of Carbon‐11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma‐1 Receptor Imaging

Advanced Science, EarlyView.
Novel carbon‐11 labeled pyrimidine derivatives are developed as PET imaging probes for visualizing sigma‐1 receptors in the brain. [11C]CNY‐01 demonstrates superior brain uptake and binding specificity in both rodents and non‐human primates. The study reveals decreased sigma‐1 receptor expression in Alzheimer's disease, offering a promising tool for ...
Ping Bai, Ashley Gomm, Chi‐Hyeon Yoo, Prasenjit Mondal, Fleur Marie Lobo, Hui Meng, Yanting Zhou, Weiyao Xie, Hsiao‐Ying Wey, Rudolph E. Tanzi, Can Zhang, Changning Wang, Yu Lan   +12 more
wiley   +1 more source

Lie Markov models with purine/pyrimidine symmetry [PDF]

arXiv, 2012
Continuous-time Markov chains are a standard tool in phylogenetic inference. If homogeneity is assumed, the chain is formulated by specifying time-independent rates of substitutions between states in the chain. In applications, there are usually extra constraints on the rates, depending on the situation.
arxiv  

Metabolomic and Cellular Mechanisms of Drug‐Induced Ototoxicity and Nephrotoxicity: Therapeutic Implications of Uric Acid Modulation

Advanced Science, EarlyView.
Drug‐induced renal damage impairs uric acid excretion, causing its accumulation in the serum, which subsequently infiltrates the cochlea. Xanthine oxidase and the ABCG2 transporter, critical in uric acid metabolism and excretion, undergo pathological changes in renal tubular and cochlear stria vascularis cells.
Suhan Guo, Cheng Cheng, Yunhao Wu, Kaidi Shen, Depeng Zhang, Bin Chen, Xinyu Wang, Luping Shen, Qixiang Zhang, Renjie Chai, Guangji Wang, Fang Zhou   +11 more
wiley   +1 more source

A DNP‐Supported Solid‐State NMR Approach to Study Nucleic Acids In Situ Reveals Berberine‐Stabilized Hoogsteen Structures in Mitochondria

Angewandte Chemie, EarlyView.
Mitochondria are vital for energy production and rely on intricate nucleic acid structures to regulate gene expression. Using DNP‐ssNMR (dynamic nuclear polarization solid‐state NMR), we observed G‐quadruplex formation in intact mitochondria treated with berberine.
Michaela Dzurov Krafčíková, David Beriashvili, Salima Bahri, Menno Bergmeijer, Stuart C. Howes, Andrei Gurinov, Friedrich G. Förster, Gert E. Folkers, Marc Baldus   +8 more
wiley   +2 more sources