Results 81 to 90 of about 314,968 (285)
Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy [PDF]
, 2017 Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Ali, Juma A.M. +7 more
core +2 more sources
Advanced NanoBiomed Research, EarlyView.Silver nanoparticles (AgNPs) synthesized using eco‐friendly green synthesis approaches exhibit remarkable antimicrobial activity and enhanced drug delivery potential. Polymer‐AgNPs conjugates further improve drug stability and targeted delivery, offering a multifunctional platform for biomedical applications.
Mukil Madhusudanan +6 more
wiley +1 more source
Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2
Nature, 2022 D. Schultz +21 more
semanticscholar +1 more source
Abiotic synthesis of purine and pyrimidine ribonucleosides in aqueous microdroplets
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance Discovery of an improved prebiotic method for the synthesis of ribonucleosides provides support to theories that posit a central role for RNA in the origin of life. It has been assumed that ribonucleosides arose through an abiotic process in
Inho Nam, H. Nam, R. Zare
semanticscholar +1 more source
Metabolism‐Regulating Nanomedicines for Cancer Therapy
Advanced NanoBiomed Research, EarlyView.This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley +1 more source
Synthesis of Pyrimidine Fused Quinolines by Ligand-Free Copper-Catalyzed Domino Reactions.
Journal of Organic Chemistry, 2018 Herein, we report two novel methods for the synthesis of pyrimidine fused quinolines using a one-pot C-C and C-N bond forming strategy from the reaction of 6-aminouracils with 2-bromobenzaldehydes or 2-bromobenzyl bromide derivatives in the presence of ...
Anoop Kumar Panday +4 more
semanticscholar +1 more source
Purine and pyrimidine bases as growth substances for lactic acid bacteria [PDF]
, 1941 In 1936 Richardson (1) showed that uracil was essential for the anaerobic growth of Staphylococcus aureus, but not for aerobic growth of the same organism.
Mitchell, Herschel K., Snell, Esmond E.
core
A tale of three kingdoms: Members of the Phylum Nematoda independently acquired the detoxifying enzyme cyanase through horizontal gene transfer from plants and bacteria [PDF]
, 2018 Horizontal gene transfer (HGT) has played an important role in the evolution of nematodes. Among candidate genes, cyanase, which is typically found only in plants, bacteria and fungi, is present in more than 35 members of the Phylum Nematoda, but absent ...
Hoberg, E. P +5 more
core +2 more sources
Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides
Nature Communications, 2017 Understanding prebiotic nucleotide synthesis is a long standing challenge thought to be essential to elucidating the origins of life on Earth. Recently, remarkable progress has been made, but to date all proposed syntheses account separately for the ...
Shaun Stairs +5 more
semanticscholar +1 more source
Arthritis &Rheumatology, EarlyView.Objective Patients with systemic lupus erythematosus (SLE) experience photosensitivity, with exposure to UVB light driving lupus flares and triggering symptoms like joint pain, fatigue, and cutaneous lesions. Although the mechanism(s) linking UVB exposure to systemic effects are unclear, type I interferons (IFNs) are known to play a role.
Gantsetseg Tumurkhuu +17 more
wiley +1 more source