Results 81 to 90 of about 197,991 (343)

Catalytic 1,2‐Migratory Insertion in a Bismuth Redox Platform: Reductive Arylation of Aldehydes

Angewandte Chemie, EarlyView.
We report a multicomponent reaction involving an aryl halide, an aldehyde, and a silane derivative, facilitated by low‐valent bismuth redox catalysis under mild conditions. The protocol represents an unprecedented example of four elementary organometallic steps at a Bi center within the catalytic cycle.
Xiangrong Liu, Hye Won Moon, Davide Spinnato, Markus Leutzsch, Josep Cornella   +4 more
wiley   +2 more sources

Diversion of aspartate in ASS1-deficient tumors fosters de novo pyrimidine synthesis

Nature, 2015
Cancer cells hijack and remodel existing metabolic pathways for their benefit. Argininosuccinate synthase (ASS1) is a urea cycle enzyme that is essential in the conversion of nitrogen from ammonia and aspartate to urea.
S. Rabinovich, Lital N Adler, Keren Yizhak, A. Sarver, Alon Silberman, Shani Agron, Noa Stettner, Qin Sun, A. Brandis, D. Helbling, S. Korman, S. Itzkovitz, D. Dimmock, I. Ulitsky, S. Nagamani, E. Ruppin, A. Erez   +16 more
semanticscholar   +1 more source

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, EarlyView.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review

Advanced Science, EarlyView.
This paper analyzes RAGE ligand‐binding mechanisms and signaling, proposing intervention strategies targeting these interactions. It emphasizes dietary polyphenols, polysaccharides, and terpenoids delivered via functional foods for anti‐aging. These compounds offer long‐term, safe intervention through dietary supplementation, providing dual nutritional
Qian Wu, Jia Yan, Yuyan Zhang, Xiaozhi Ming, Siqi Chen, Zhichao Zou, Nianjie Feng, Jianbo Xiao   +7 more
wiley   +1 more source

Disruption of nucleotide biosynthesis reprograms mitochondrial metabolism to inhibit adipogenesis

Journal of Lipid Research
A key organismal response to overnutrition involves the development of new adipocytes through the process of adipogenesis. Preadipocytes sense changes in the systemic nutrient status and metabolites can directly modulate adipogenesis.
Julia A. Pinette, Jacob W. Myers, Woo Yong Park, Heather G. Bryant, Alex M. Eddie, Genesis A. Wilson, Claudia Montufar, Zayedali Shaikh, Zer Vue, Elizabeth R. Nunn, Ryoichi Bessho, Matthew A. Cottam, Volker H. Haase, Antentor O. Hinton, Jessica B. Spinelli, Jean-Philippe Cartailler, Elma Zaganjor   +16 more
doaj   +1 more source

Abiotic synthesis of purine and pyrimidine ribonucleosides in aqueous microdroplets

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance Discovery of an improved prebiotic method for the synthesis of ribonucleosides provides support to theories that posit a central role for RNA in the origin of life. It has been assumed that ribonucleosides arose through an abiotic process in
Inho Nam, H. Nam, R. Zare
semanticscholar   +1 more source

Illuminating Tau Aggregates: Multiscale Approaches for Detection, Imaging, and Understanding

Aggregate, EarlyView.
This review presents recent advances in molecular imaging of tauopathies, focusing on tau aggregation mechanisms, structural polymorphism, and imaging strategies. It highlights the development of tau‐selective fluorescent probes and PET tracers and explores emerging techniques such as cryo‐EM and super‐resolution imaging, offering a multiscale ...
Kaustubh R. Bhuskute, Jiayi Fan, Amandeep Kaur   +2 more
wiley   +1 more source

Smiles‐Truce Cascades Enable Heteroaryl Cyclopropane and Sultine Synthesis

Angewandte Chemie, EarlyView.
A triple C─C cascade approach to the synthesis of heteroaryl cyclopropanes is described. The reaction is metal‐free, uses simple starting materials, and presents a new retrosynthetic approach for heteroaryl cyclopropane synthesis. A change of substituent creates a new route to sultines, under‐explored motifs in medicinal chemistry. Abstract We describe
Thomas Sephton, Zi Liu, Michael F. Greaney   +2 more
wiley   +2 more sources

Synthesis of Pyrimidine Fused Quinolines by Ligand-Free Copper-Catalyzed Domino Reactions.

Journal of Organic Chemistry, 2018
Herein, we report two novel methods for the synthesis of pyrimidine fused quinolines using a one-pot C-C and C-N bond forming strategy from the reaction of 6-aminouracils with 2-bromobenzaldehydes or 2-bromobenzyl bromide derivatives in the presence of ...
Anoop Kumar Panday, Richa Mishra, A. Jana, Tasneem Parvin, Lokman H. Choudhury   +4 more
semanticscholar   +1 more source

Phenotypical and Genotypical Expansion of Autosomal‐Dominant KDM1A‐Related Neurodevelopmental Disorder Spectrum: A Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT KDM1A‐related neurodevelopmental disorder (CPRF, OMIM #616728) is characterized by cleft palate, global developmental delay, and distinct facial gestalt, but phenotypic knowledge of this ultra‐rare autosomal dominant disorder is limited. Here, we report on a 13‐year‐old boy with a novel heterozygous, likely pathogenic germline missense variant
Sebastian Burkart, Melanie Spanjaard, Lilian Kaufmann, Katrin Hinderhofer, Christian P. Schaaf, Markus Ries, Maja Hempel   +6 more
wiley   +1 more source