Results 141 to 150 of about 14,504 (194)
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PYRIMIDINE DIMER FORMATION IN HUMAN SKIN
Photochemistry and Photobiology, 1987AbstractCyclobutyl pyrimidine dimers are major photoproducts formed upon irradiation of DNA with ultraviolet light. We have developed a method for detecting as few as one pyrimidine dimer per million bases in about 50 ng of non‐radioactive DNA, and have used this method to quantitate dimer yields in human skin DNA exposed in situ to UV.
S E, Freeman +3 more
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Pyrimidine dimers in ultraviolet-irradiated DNA's
Journal of Molecular Biology, 1966DNA's of various compositions, labeled with radioactive cytosine or thymine, were irradiated with monochromatic ultraviolet light and analyzed by photochemical and chromatographic techniques for photoproducts. The dimers T T ⌢ ,† C T ⌢ and C C ⌢ were identified as primary photochemical products, and U T
R B, Setlow, W L, Carrier
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Biological consequences of cyclobutane pyrimidine dimers
Journal of Photochemistry and Photobiology B: Biology, 2001In the skin many molecules may absorb ultraviolet (UV) radiation upon exposure. In particular, cellular DNA strongly absorbs shorter wavelength solar UV radiation, resulting in various types of DNA damage. Among the DNA photoproducts produced the cyclobutane pyrimidine dimers (CPDs) are predominant.
Vink, A.A., Roza, L.
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Photomonomerization of pyrimidine dimers by indoles and proteins
Journal of Theoretical Biology, 1976Abstract Model systems for the study of photoreactivation have been developed that utilize a variety of indole derivatives. These systems can split uracil cis-syn cyclobutadipyrimidine, either free or in RNA, when irradiated at wave-lengths absorbed only by the indole moiety. The ability of indole compounds to split dimers is closely related to their
J, Chen +4 more
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Repair of DNA‐containing pyrimidine dimers
The FASEB Journal, 1988Ultraviolet light‐induced pyrimidine dimers in DNA are recognized and repaired by a number of unique cellular surveillance systems. The most direct biochemical mechanism responding to this kind of geno‐toxicity involves direct photoreversal by flavin enzymes that specifically monomerize pyrimidine:pyrimidine dimers monophotonically
L, Grossman +3 more
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Nature, 1980
Pyrimidine dimer formation in response to UV radiation is governed by the thymine content of the potential dimer and the two flanking nucleotides. An enzymatic activity can be purified from Micrococcus luteus that cleaves the N-glycosyl bond between the 5' pyrimidine of a dimer and the corresponding sugar without rupture of a phosphodiester bond.
W A, Haseltine +5 more
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Pyrimidine dimer formation in response to UV radiation is governed by the thymine content of the potential dimer and the two flanking nucleotides. An enzymatic activity can be purified from Micrococcus luteus that cleaves the N-glycosyl bond between the 5' pyrimidine of a dimer and the corresponding sugar without rupture of a phosphodiester bond.
W A, Haseltine +5 more
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Pyrimidine dimer splitting in covalently linked dimer—arylamine systems
Journal of Photochemistry and Photobiology B: Biology, 1992Cyclobutadipyrimidines (pyrimidine dimers) undergo photosplitting which is sensitized by electron donors. We prepared a series of compounds in which a dimer is directly linked to an arylamine, which acts as sensitizer for dimer splitting. Two diastereomers of the dimer-arylamine exhibited very different splitting efficiencies.
S T, Kim, S D, Rose
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Are pyrimidine dimers Non-Instructive lesions?
Molecular and General Genetics MGG, 1981Published data from yeast and E. coli show that base substitution induced by UV in pyrimidine-pyrimidine sequences is not random, and suggest that fidelity of DNA replication is not entirely lost during transdimer synthesis. These observations question whether cyclobutane pyrimidine dimers are truly non-instructive lesions.
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Electrochemically induced pyrimidine dimerization
Bioelectrochemistry and Bioenergetics, 1974Abstract A study has been made of the polarographic behaviour and the mechanisms of electroreduction of N-methyl derivatives of pyrimidone-2 and 4-methylthiouracils. One of the major electroreduction products of all the foregoing is a 6,6′-bis(3,6-dihydro-pyrimidone-2) dimer similar to that previously described as the major reduction product of the ...
Barbara Czochralska +2 more
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Pyrimidine Dimers: Effect of Temperature on Photoinduction
Science, 1966Ultraviolet-induced pyrimidine dimer formation in DNA and polyuridylic acid was inhibited on irradiation at 77°K. Enhancement of thymine dimer formation in solutions of DNA occurred upon addition of ethylene glycol. Low temperature measurements of absorbance of polyuridylic acid at low temperature showed that no significant alteration of the residues ...
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